考迈斯托醇
| 中文名称 | 考迈斯托醇 |
|---|---|
| 中文同义词 | 拟雌内酯, >98%;拟雌内酯;香豆雌酚;ES2细胞增殖抑制剂(COUMESTROL);考迈斯托醇;香豆雌酚(拟雌内酯;3,9-二羟基-6H-苯并呋喃并[3,2-C]苯并吡喃-6-酮;拟雌内酯,10 MM DMSO 溶液 |
| 英文名称 | COUMESTROL |
| 英文同义词 | cumoesterol;COUMOESTROL;7 12-DIHYDROXYCOUMESTAN 98%;Coumesterol;COUMESTROL(P);Coumestrol, >98%;3,9-dihydroxy-6-benzofuro[3,2-c][1]benzopyranone;2-(2 4-DIHYDROXYPHENYL)-6-HYDROXY-3-BENZOFURANCARBOXYLIC ACID D-LACTONE 98% |
| CAS号 | 479-13-0 |
| 分子式 | C15H8O5 |
| 分子量 | 268.22 |
| EINECS号 | 207-525-6 |
| 相关类别 | 对照品;细胞生物学试剂;植物提取物;木脂素;对照品;Steroids & Hormones - 13C & 2H;Steroids;Coumarins;Iso-Flavones |
| Mol文件 | 479-13-0.mol |
| 结构式 |  |
考迈斯托醇 性质
| 熔点 | ≥350 °C(lit.) |
|---|---|
| 沸点 | 331.39°C (rough estimate) |
| 密度 | 1.2586 (rough estimate) |
| 折射率 | 1.7680 (estimate) |
| 储存条件 | Refrigerator |
| 溶解度 | 可溶于DMSO |
| 酸度系数(pKa) | 8.25±0.20(Predicted) |
| 形态 | 浅米色固体。 |
| 颜色 | 淡黄色至深棕色 |
| BRN | 266702 |
| InChI | InChI=1S/C15H8O5/c16-7-1-3-9-11(5-7)19-14-10-4-2-8(17)6-12(10)20-15(18)13(9)14/h1-6,16-17H |
| InChIKey | ZZIALNLLNHEQPJ-UHFFFAOYSA-N |
| SMILES | C1(=O)OC2=CC(O)=CC=C2C2OC3=CC(O)=CC=C3C1=2 |
| LogP | 2.940 (est) |
| CAS 数据库 | 479-13-0(CAS DataBase Reference) |
| EPA化学物质信息 | Coumestrol (479-13-0) |
IC50: 50 μM
Coumestrol exerts chemotherapeutic effects via PI3K and ERK1/2 MAPK pathways. Coumestrol inhibits viability and invasion, and induces apoptosis of ES2 (clear cell-/serous carcinoma origin) cells. In addition, immunoreactive PCNA and ERBB2, markers of proliferation of ovarian carcinoma, are attenuated in their expression in coumestrol-induced death of ES2 cells. Phosphorylation of AKT, p70S6K, ERK1/2, JNK1/2 and p90RSK is inactivated by coumestrol treatment in a dose- and time-dependent manner. Coumestrol inhibits proliferation and induces apoptosis in MCF-7 cells, which is prevented by copper chelator neocuproine and ROS scavengers. Coumestrol treatment induces ROS generation coupled to DNA fragmentation, up-regulation of p53/p21, cell cycle arrest at G1/S phase, mitochondrial membrane depolarization and caspases 9/3 activation.
安全信息
| 危险品标志 | Xn |
|---|---|
| 危险类别码 | 22-36/37/38 |
| 安全说明 | 26-36 |
| WGK Germany | 3 |
| RTECS号 | DF8077000 |
| F | 10 |
| TSCA | TSCA listed |
| 存储类别 | 11 - 可燃固体 |
| 危险性类别 | 急性毒性 类别4 经口 眼部刺激 类别2 经皮刺激 类别2 特异性靶器官毒性-一次接触，类别3 |
| 提供商 | 语言 |
|---|---|
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英文
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