1-BOC-4-甲酰基-4-甲基哌啶
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- CAS号:
- 189442-92-0
- 英文名:
- 1-BOC-4-FORMYL-4-METHYL-PIPERIDINE
- 英文别名:
- 1-BOC-4-FORMYL-4-METHYL-PIPERIDINE;1-Boc-4-methylpiperidine-4-carbaldehyde;4-Formyl-4-methylpiperidine-1-carboxylic acid;TERT-BUTYL 4-FORMYL-4-METHYLPIPERIDINE-1-CARBOXYLAT;tert-Butyl 4-formyl-4-methylpiperidine-1-carboxylate;1-tert-Butoxycarbonyl-4-methylpiperidine-4-carboxaldehyde;N-tert-Butoxycarbonyl-4-methyl-4-piperidine carboxaldehyde;2-Methyl-2-Propanyl 4-ForMyl-4-Methyl-1-Piperidinecarboxylate;1-Piperidinecarboxylic acid, 4-formyl-4-methyl-, 1,1-dimethylethyl ester
- 中文名:
- 1-BOC-4-甲酰基-4-甲基哌啶
- 中文别名:
- 1-BOC-4-甲基哌啶-4-甲醛;N-BOC-4-甲酰基-4-甲基哌啶;1-BOC-4-甲酰基-4-甲基哌啶;4-甲酰基-4-甲基哌啶-1-羧酸叔丁酯;叔-丁基 4-甲酰基-4-甲基哌啶-1-甲酸基酯;2-甲基-2-丙基4-甲酰基-4-甲基-1-哌啶羧酸酯
- CBNumber:
- CB7145232
- 分子式:
- C12H21NO3
- 分子量:
- 227.3
- MOL File:
- 189442-92-0.mol
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1-BOC-4-甲酰基-4-甲基哌啶化学性质
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沸点:
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300.3±35.0 °C(Predicted)
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密度:
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1.083±0.06 g/cm3(Predicted)
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储存条件:
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Inert atmosphere,Store in freezer, under -20°C
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酸度系数(pKa):
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-2.10±0.40(Predicted)
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外观:
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Colorless to light yellow Liquid
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1-BOC-4-甲酰基-4-甲基哌啶性质、用途与生产工艺
生产方法
将1-叔丁氧羰基哌啶-4-甲醛（35.0g，164.1mmol）溶解于二氯甲烷（200mL）中，并将溶液冷却至0℃。在搅拌下，向溶液中加入叔丁醇钾（23.9g，213mmol），随后缓慢加入碘甲烷（69.9g，492mmol）。反应混合物在0℃下搅拌30分钟后，逐渐升温至室温并继续搅拌1.5小时。反应完成后，将混合物倒入盐水（400mL）中，分离有机层。有机层用无水硫酸钠干燥，过滤后浓缩。粗产物通过硅胶柱层析纯化，得到1-Boc-4-甲酰基-4-甲基哌啶（16.36g，72.0mmol，收率43.8%）。
参考文献：
[1] Patent: WO2008/118718, 2008, A2. Location in patent: Page/Page column 84
[2] Patent: WO2014/28384, 2014, A1. Location in patent: Page/Page column 112
[3] Patent: WO2014/164467, 2014, A1. Location in patent: Page/Page column 65
[4] Patent: WO2014/164428, 2014, A1. Location in patent: Page/Page column 61
[5] Patent: WO2013/127828, 2013, A1. Location in patent: Page/Page column 62
1-BOC-4-甲酰基-4-甲基哌啶
上下游产品信息
上游原料
下游产品
189442-92-0, 1-BOC-4-甲酰基-4-甲基哌啶 相关搜索:
- 叔-丁基 4-甲酰基-4-甲基哌啶-1-甲酸基酯
- 1-BOC-4-甲基哌啶-4-甲醛
- 2-甲基-2-丙基4-甲酰基-4-甲基-1-哌啶羧酸酯
- 4-甲酰基-4-甲基哌啶-1-羧酸叔丁酯
- N-BOC-4-甲酰基-4-甲基哌啶
- 1-BOC-4-甲酰基-4-甲基哌啶
- 189442-92-0
- 1-Boc-4-methylpiperidine-4-carbaldehyde
- TERT-BUTYL 4-FORMYL-4-METHYLPIPERIDINE-1-CARBOXYLAT
- 1-Piperidinecarboxylic acid, 4-formyl-4-methyl-, 1,1-dimethylethyl ester
- N-tert-Butoxycarbonyl-4-methyl-4-piperidine carboxaldehyde
- tert-Butyl 4-formyl-4-methylpiperidine-1-carboxylate
- 4-Formyl-4-methylpiperidine-1-carboxylic acid
- 1-tert-Butoxycarbonyl-4-methylpiperidine-4-carboxaldehyde
- 2-Methyl-2-Propanyl 4-ForMyl-4-Methyl-1-Piperidinecarboxylate
- 1-BOC-4-FORMYL-4-METHYL-PIPERIDINE