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1-Boc-4-formyl-4-methyl-piperidine

1-Boc-4-formyl-4-methyl-piperidine Structure
1-Boc-4-formyl-4-methyl-piperidine structure
CAS No.
189442-92-0
Chemical Name:
1-Boc-4-formyl-4-methyl-piperidine
Synonyms
1-Boc-4-methylpiperidine-4-carbaldehyde;tert-Butyl 4-formyl-4-methylpiperidine-1-carboxylate;1-Boc-4-formyl-4-methyl-piperidine;4-Formyl-4-methylpiperidine-1-carboxylic acid;TERT-BUTYL 4-FORMYL-4-METHYLPIPERIDINE-1-CARBOXYLAT;1-tert-Butoxycarbonyl-4-methylpiperidine-4-carboxaldehyde;N-tert-Butoxycarbonyl-4-methyl-4-piperidine carboxaldehyde;2-Methyl-2-Propanyl 4-ForMyl-4-Methyl-1-Piperidinecarboxylate;1-Piperidinecarboxylic acid, 4-formyl-4-methyl-, 1,1-dimethylethyl ester
CBNumber:
CB7145232
Molecular Formula:
C12H21NO3
Molecular Weight:
227.3
MDL Number:
MFCD08062517
MOL File:
189442-92-0.mol
MSDS File:
SDS
Last updated:2026-09-12 18:54:35
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1-Boc-4-formyl-4-methyl-piperidine Properties

Boiling point 300.3±35.0 °C(Predicted)
Density 1.083±0.06 g/cm3(Predicted)
storage temp. Inert atmosphere,Store in freezer, under -20°C
pka -2.10±0.40(Predicted)
Appearance Colorless to light yellow Liquid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H335-H302-H319
Precautionary statements  P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362

1-Boc-4-formyl-4-methyl-piperidine price More Price(35)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth PHA44292 1-Boc-4-Formyl-4-methylpiperidine 189442-92-0 1g $306.8 2026-06-04 Buy
Biosynth PHA44292 1-Boc-4-Formyl-4-methylpiperidine 189442-92-0 10g $1416 2026-06-04 Buy
Matrix Scientific 112950 1-Boc-4-formyl-4-methylpiperidine 189442-92-0 1.00g $125 2026-05-18 Buy
Matrix Scientific 112950 1-Boc-4-formyl-4-methylpiperidine 189442-92-0 5.00g $379 2026-05-18 Buy
Matrix Scientific 112950 1-Boc-4-formyl-4-methylpiperidine 189442-92-0 10.00g $644 2026-05-18 Buy
Product number Packaging Price Buy
PHA44292 1g $306.8 Buy
PHA44292 10g $1416 Buy
112950 1.00g $125 Buy
112950 5.00g $379 Buy
112950 10.00g $644 Buy

1-Boc-4-formyl-4-methyl-piperidine Chemical Properties, Uses, Production

Synthesis

1-tert-Butoxycarbonyl-4-piperidinecarboxaldehyde

137076-22-3

Iodomethane

74-88-4

1-BOC-4-FORMYL-4-METHYL-PIPERIDINE

189442-92-0

1-Boc piperidine-4-carbaldehyde (35.0 g, 164.1 mmol) was dissolved in dichloromethane (200 mL) and the solution was cooled to 0 °C. Potassium tert-butoxide (23.9 g, 213 mmol) was added to the solution with stirring, followed by slow addition of iodomethane (69.9 g, 492 mmol). The reaction mixture was stirred at 0 °C for 30 min, then gradually warmed to room temperature and continued stirring for 1.5 h. The reaction was completed by pouring the mixture into the solution. After completion of the reaction, the mixture was poured into brine (400 mL) and the organic layer was separated. The organic layer was dried with anhydrous sodium sulfate, filtered and concentrated. The crude product was purified by silica gel column chromatography to afford 1-Boc-4-formyl-4-methylpiperidine (16.36 g, 72.0 mmol, 43.8% yield).

References

[1] Patent: WO2008/118718, 2008, A2. Location in patent: Page/Page column 84
[2] Patent: WO2014/28384, 2014, A1. Location in patent: Page/Page column 112
[3] Patent: WO2014/164467, 2014, A1. Location in patent: Page/Page column 65
[4] Patent: WO2014/164428, 2014, A1. Location in patent: Page/Page column 61
[5] Patent: WO2013/127828, 2013, A1. Location in patent: Page/Page column 62

1-Boc-4-formyl-4-methyl-piperidine Preparation Products And Raw materials

Raw materials

1-tert-Butoxycarbonyl-4-piperidinecarboxaldehyde Iodomethane Dichloromethane Potassium Recombinant Human Telomerase

Preparation Products

1-Boc-4-formyl-4-methyl-piperidine Suppliers

Global Suppliers ( 82)
Supplier Tel Email Country ProdList Advantage
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 45000 61
Changzhou Shili Pharmaceutical Technology Co., Ltd 051988727299; 13961229012 shitech@163.com China 299 58
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Shanghai AmasPharm Co., Ltd. 021-54540637 18621091017 sales@amaspharm.com China 791 62
Shanghai Sunway Pharmaceutical Technology Co., Ltd 13761987713 hxzheng@sunwaypharm.cn China 8663 57
ZhengZhou HuaWen Chemical Co.Ltd 0370-2785118 17550508557 675141927@qq.com China 3201 55
Shanghai Jian Chao Chemical Technology Co., Ltd. 150-2103-5486 18017383231 983544897@qq.com China 9335 55
Shanghai Raise Chemical Technology Co.,Ltd 15026594951 rs@raise-chem.com China 4941 55
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Chengdu Firster Pharmaceutical Co., Ltd. 028-87078428 028-87074958 chengzhenyong@cdfirster.com China 2579 60
Supplier Advantage
Energy Chemical 61
Changzhou Shili Pharmaceutical Technology Co., Ltd 58
Pure Chemistry Scientific Inc. 62
Shanghai AmasPharm Co., Ltd. 62
Shanghai Sunway Pharmaceutical Technology Co., Ltd 57
ZhengZhou HuaWen Chemical Co.Ltd 55
Shanghai Jian Chao Chemical Technology Co., Ltd. 55
Shanghai Raise Chemical Technology Co.,Ltd 55
Bide Pharmatech Ltd. 60
Chengdu Firster Pharmaceutical Co., Ltd. 60

View Latest Price from 1-Boc-4-formyl-4-methyl-piperidine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1-BOC-4-FORMYL-4-METHYL-PIPERIDINE pictures 2020-01-10 1-BOC-4-FORMYL-4-METHYL-PIPERIDINE
189442-92-0
 $5.50 1KG 98%min 1kg,10kg,100kg Career Henan Chemical Co

1-Boc-4-formyl-4-methyl-piperidine Spectrum

1-BOC-4-FORMYL-4-METHYL-PIPERIDINE(189442-92-0)1HNMR

189442-92-0 (1-Boc-4-formyl-4-methyl-piperidine) Related Search:

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N-Boc-4-benzyl-4-piperidinecarboxylic methyl ester 1-Boc-4-spiro-[3-(2-pyrrolidinone)] piperidine N-Boc-4-benzyl-4-piperidinecarboxylic acid 1-Boc-4-ethyl-4-formyl-piperidine Methyl 4-aminomethyl-1-Boc-piperidine-4-carboxylate
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N-Boc-1-[4-spiro-piperidine]-2-indanone 4-(1-Hydroxy-1-methyl-ethyl)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester N-Boc-4-(2'-nitro) benzyl-4-piperidine carboxylic acid

1of4

2-Methyl-2-Propanyl 4-ForMyl-4-Methyl-1-Piperidinecarboxylate 1-tert-Butoxycarbonyl-4-methylpiperidine-4-carboxaldehyde 4-Formyl-4-methylpiperidine-1-carboxylic acid N-tert-Butoxycarbonyl-4-methyl-4-piperidine carboxaldehyde 1-Piperidinecarboxylic acid, 4-formyl-4-methyl-, 1,1-dimethylethyl ester TERT-BUTYL 4-FORMYL-4-METHYLPIPERIDINE-1-CARBOXYLAT 1-Boc-4-methylpiperidine-4-carbaldehyde tert-Butyl 4-formyl-4-methylpiperidine-1-carboxylate 1-Boc-4-formyl-4-methyl-piperidine 189442-92-0