5-CHLORO-2'-DEOXYURIDINE
|
|
|
- CAS-Nr.
- 50-90-8
- Englisch Name:
- 5-CHLORO-2'-DEOXYURIDINE
- Synonyma:
- CldU;CLUDR;NSC-371331, CDC;Chlorodeoxyuridine;5-Chlorodeoxyuridin;5-CHLORODEOXYURIDINE;5-CHLORODESOXYURIDINE;5-chloro-2’-deoxy-uridin;5-CHLORO-2'-DEOXYURIDINE;2'-DEOXY-5-CHLOROURIDINE
- CBNumber:
- CB0246956
- Summenformel:
- C9H11ClN2O5
- Molgewicht:
- 262.65
- MOL-Datei:
- 50-90-8.mol
|
5-CHLORO-2'-DEOXYURIDINE Eigenschaften
- Schmelzpunkt:
- 176-179°C
- Dichte
- 1.5507 (rough estimate)
- Brechungsindex
- 1.6500 (estimate)
- storage temp.
- -20°C
- Löslichkeit
- DMSO (Slightly), Methanol (Slightly), Water (Slightly)
- Aggregatzustand
- Solid
- pka
- 7.73±0.10(Predicted)
- Farbe
- White to Off-White
- InChI
- InChI=1S/C9H11ClN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1
- InChIKey
- NJCXGFKPQSFZIB-RRKCRQDMSA-N
- SMILES
- OC[C@H]1O[C@@H](N2C=C(Cl)C(=O)NC2=O)C[C@@H]1O
- CAS Datenbank
- 50-90-8(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
Xn |
|
|
| R-Sätze: |
20/21/22-40 |
|
|
| S-Sätze: |
36/37/39-45 |
|
|
| WGK Germany |
3 |
|
|
| RTECS-Nr. |
YU7400000 |
|
|
| HS Code |
29349990 |
|
|
| Speicherklasse |
11 - Combustible Solids |
|
|
| Hazard Classifications |
Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Carc. 2 |
|
|
| Bildanzeige (GHS) |
 
|
| Alarmwort |
Warnung
|
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H351 |
Kann vermutlich Krebs verursachen. |
Karzinogenität |
Kategorie 2 |
Warnung |
|
P201, P202, P281, P308+P313, P405,P501 |
|
| Sicherheit |
| P202 |
Vor Gebrauch alle Sicherheitshinweise lesen und verstehen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P308+P313 |
BEI Exposition oder falls betroffen: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen. |
|
5-CHLORO-2'-DEOXYURIDINE Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R40:Verdacht auf krebserzeugende Wirkung.
S-Sätze Betriebsanweisung:
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Beschreibung
5-Chloro-2''-deoxyuridine (CldU) is a thymidine analog that is readily incorporated, following phosphorylation, into newly synthesized DNA in place of thymidine. Like 5-bromo-2’-deoxyuridine and 5-iodo-2’-deoxyuridine, CldU can be detected immunologically in cells and tissues. CldU can also be added to cells or tissues sequentially with another thymidine analog to label temporally distinct populations. The insertion of thymidine analogs, including CldU, can significantly alter DNA processing and replication, so these analogs have also been used as mutagens, clastogens, and antiviral compounds.
Chemische Eigenschaften
White Needles
Verwenden
5-Chloro-2'-deoxyuridine (CldU) is a thymidine analog that is readily incorporated, following phosphorylation, into newly synthesized DNA in place of thymidine. Like 5-bromo-2’-deoxyuridine and 5-iodo-2’-deoxyuridine, CldU can be detected immunologically in cells and tissues. CldU can also be added to cells or tissues sequentially with another thymidine analog to label temporally distinct populations. The insertion of thymidine analogs, including CldU, can significantly alter DNA processing and replication, so these analogs have also been used as mutagens, clastogens, and antiviral compounds.[Cayman Chemical]
5-CHLORO-2'-DEOXYURIDINE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
5-CHLORO-2'-DEOXYURIDINE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 117)Lieferanten
50-90-8()Verwandte Suche:
- 2'-DEOXY-5-CHLOROURIDINE
- 5-CHLORODESOXYURIDINE
- 5-CHLORO-2'-DEOXYURIDINE
- 5-chloro-2’-deoxy-uridin
- 5-Chlorodeoxyuridin
- 5-Chloro-2'-deoxy-D-uridine
- 5-CHLORODEOXYURIDINE
- Chlorodeoxyuridine
- 5-CHLORO-1-[(2R,4S,5R)-4-HYDROXY-5-(HYDROXYMETHYL)OXOLAN-2-YL]-3H-PYRIMIDINE-2,4-DIONE
- CldU
- CLUDR
- 5-chloro-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
- 5-chloro-1-[(2R,4S,5R)-4-hydroxy-5-methylol-tetrahydrofuran-2-yl]pyrimidine-2,4-quinone
- 5-Chloro-2'-deoxyuridine ,98%
- 5-chloro-1-((2R,4S,5R)-4-hydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dione
- Uridine,5-chloro-2'-deoxy-
- NSC-371331, CDC
- 5-CHLORO-2'-DEOXYURIDINE USP/EP/BP
- 5-Chloro-2’-deoxy uridine NSC-371331, CDC,Radio-sensitizing agent for cancer treatment,anticancer agent
- Inhibitor,inhibit,5Chloro2'deoxyuridine,5 Chloro 2' deoxyuridine
- 5-Chloro-2’-deoxyuridine
- CldU (5-chloro-2''-deoxyuridine), Halogenated uridine derivative
- 5-Chloro-2''-deoxyuridine
- 5-Chloro-2''-deoxyuridine, 10 mM in DMSO
- 50-90-8
- Biochemicals and Reagents
- BioChemical
- Nucleosides, Nucleotides, Oligonucleotides
- Nucleoside Analogs
- API intermediates
- Bases & Related Reagents
- Carbohydrates & Derivatives
- Heterocycles
- Nucleotides
- Biochemicals and Reagents
- Nucleoside Analogs
- Nucleosides, Nucleotides, Oligonucleotides
