5-Chloro-2'-deoxyuridine
- CAS No.
- 50-90-8
- Chemical Name:
- 5-Chloro-2'-deoxyuridine
- Synonyms
- CldU;CLUDR;NSC-371331, CDC;Chlorodeoxyuridine;5-Chlorodeoxyuridin;5-CHLORODEOXYURIDINE;5-CHLORODESOXYURIDINE;5-chloro-2’-deoxy-uridin;2'-DEOXY-5-CHLOROURIDINE;5-Chloro-2’-deoxyuridine
- CBNumber:
- CB0246956
- Molecular Formula:
- C9H11ClN2O5
- Molecular Weight:
- 262.65
- MDL Number:
- MFCD00006531
- MOL File:
- 50-90-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 176-179°C |
|---|---|
| Density | 1.5507 (rough estimate) |
| refractive index | 1.6500 (estimate) |
| storage temp. | -20°C |
| solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
| form | Solid |
| pka | 7.73±0.10(Predicted) |
| color | White to Off-White |
| InChI | InChI=1S/C9H11ClN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1 |
| InChIKey | NJCXGFKPQSFZIB-RRKCRQDMSA-N |
| SMILES | OC[C@H]1O[C@@H](N2C=C(Cl)C(=O)NC2=O)C[C@@H]1O |
| CAS DataBase Reference | 50-90-8(CAS DataBase Reference) |
| UNSPSC Code | 41106305 |
| NACRES | NA.51 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332-H351 | |||||||||
| Precautionary statements | P202-P280-P301+P312-P302+P352+P312-P304+P340+P312-P308+P313 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 20/21/22-40 | |||||||||
| Safety Statements | 36/37/39-45 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | YU7400000 | |||||||||
| HS Code | 29349990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Dermal Acute Tox. 4 Inhalation Acute Tox. 4 Oral Carc. 2 |
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| NFPA 704 |
|
5-Chloro-2'-deoxyuridine price More Price(48)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C6891 | 5-Chloro-2′-deoxyuridine thymidine analog | 50-90-8 | 100mg | $111 | 2026-04-30 | Buy |
| Cayman Chemical | 18155 | 5-Chloro-2''-deoxyuridine ≥98% | 50-90-8 | 25mg | $44 | 2026-04-30 | Buy |
| Cayman Chemical | 18155 | 5-Chloro-2''-deoxyuridine ≥98% | 50-90-8 | 50mg | $71 | 2026-04-30 | Buy |
| Cayman Chemical | 18155 | 5-Chloro-2''-deoxyuridine ≥98% | 50-90-8 | 100mg | $106 | 2026-04-30 | Buy |
| Cayman Chemical | 18155 | 5-Chloro-2''-deoxyuridine ≥98% | 50-90-8 | 25 mg | $40 | 2024-03-01 | Buy |
5-Chloro-2'-deoxyuridine Chemical Properties, Uses, Production
Description
5-Chloro-2''-deoxyuridine (CldU) is a thymidine analog that is readily incorporated, following phosphorylation, into newly synthesized DNA in place of thymidine. Like 5-bromo-2’-deoxyuridine and 5-iodo-2’-deoxyuridine, CldU can be detected immunologically in cells and tissues. CldU can also be added to cells or tissues sequentially with another thymidine analog to label temporally distinct populations. The insertion of thymidine analogs, including CldU, can significantly alter DNA processing and replication, so these analogs have also been used as mutagens, clastogens, and antiviral compounds.
Chemical Properties
White Needles
Uses
A halogenated uridine derivative used in pharmaceutical compositions.
Uses
5-Chloro-2'-deoxyuridine (CldU) is a thymidine analog that is readily incorporated, following phosphorylation, into newly synthesized DNA in place of thymidine. Like 5-bromo-2’-deoxyuridine and 5-iodo-2’-deoxyuridine, CldU can be detected immunologically in cells and tissues. CldU can also be added to cells or tissues sequentially with another thymidine analog to label temporally distinct populations. The insertion of thymidine analogs, including CldU, can significantly alter DNA processing and replication, so these analogs have also been used as mutagens, clastogens, and antiviral compounds.[Cayman Chemical]
Uses
5-Chloro-2′-deoxyuridine (CldU) is used as a thymidine analog to study the miscoding potential of hypochlorous acid damage to DNA and DNA precursors. When used with antibody based immunofluorescent imaging, 5-Chloro-2′-deoxyuridine incorporation may be used in protocols to identify sites of DNA replication. CldU may be used as a labeling substrate in conjunction with other halogenated uridine labeling substrates such as iododeoxyuridine (IdU).
Biochem/physiol Actions
DNA labeled with 5-chloro-2′-deoxyuridine (CldU) serves as an effective tool to analyze and quantify DNA replication, repair, and recombination. CldU is a potent mutagen, clastogen, and toxicant. It is used as a thymidine analog and is found to alter the dNTP pools and might lead to cell-cycle arrest. CldU produces sister-chromatid exchange but has less response to ionizing radiation compared to other thymine analogs. 5-Chloro-2′-deoxyuridine (CldU) is used to study the miscoding potential of hypochlorous acid damage to DNA and DNA precursors. When used with antibody based immunofluorescent imaging, 5-Chloro-2′-deoxyuridine incorporation may be used in protocols to identify sites of DNA replication. CldU may be used as a labeling substrate in conjunction with other halogenated uridine labeling substrates such as iododeoxyuridine (IdU).
References
[1] AMRITRAJ PATRA. Structure, stability and function of 5-chlorouracil modified A:U and G:U base pairs.[J]. Nucleic Acids Research, 2013: 2689-2697. DOI: 10.1093/nar/gks1316
[2] CLARA J. YUAN . Extended access methamphetamine decreases immature neurons in the hippocampus which results from loss and altered development of neural progenitors without altered dynamics of the S-phase of the cell cycle[J]. Pharmacology Biochemistry and Behavior, 2011, 100 1: Pages 98-108. DOI: 10.1016/j.pbb.2011.08.004
[3] SILJE ANDA Beata G Erik Boye. Cell-cycle analyses using thymidine analogues in fission yeast.[J]. PLoS ONE, 2014: e88629. DOI: 10.1371/journal.pone.0088629
[4] MARíA LLORENS-MARTíN José L T Gonzalo S Tejeda. Differential regulation of the variations induced by environmental richness in adult neurogenesis as a function of time: a dual birthdating analysis.[J]. PLoS ONE, 2010: e12188. DOI: 10.1371/journal.pone.0012188
[5] ALEX H TUTTLE. Immunofluorescent detection of two thymidine analogues (CldU and IdU) in primary tissue.[J]. Jove-Journal of Visualized Experiments, 2010, 46. DOI: 10.3791/2166
[6] L M FOX. Capacity of deoxycytidine to selectively antagonize cytotoxicity of 5-halogenated analogs of deoxycytidine without loss of antiherpetic activity.[J]. Antimicrobial Agents and Chemotherapy, 1982, 22 3: 431-441. DOI: 10.1128/aac.22.3.431
5-Chloro-2'-deoxyuridine Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Yingxin laboratory equipment Co., Ltd | 021-021-59178156 15300768757 | 359382369@qq.com | China | 10667 | 58 |
| Hangzhou FuRun Pharmaceutical Technology Co., Ltd | 15658004993 | 1900830611@qq.com | China | 980 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 | |
| Nanjing Baifuli Technology Co., Ltd. | 25-25-58740604 15951658055 | sales@unisyn.cn | China | 622 | 58 |
| Zhengzhou GranLen pharmaceutical Technology Co., Ltd. | 0371-85513397 | info@granlen.com | China | 497 | 55 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29977 | 65 |
| Shanghai Meishui Chemical Technology Co., Ltd | 021-60549325 18616193163 | China | 4518 | 56 |
View Latest Price from 5-Chloro-2'-deoxyuridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-10 | 5-Chloro-2'-deoxyuridine
50-90-8
|
$30.00-40.00 | 99.54% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-06-30 | 5-CHLORO-2'-DEOXYURIDINE
50-90-8
|
1kg | 98% | 1000kg | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2021-08-12 | 5-CHLORO-2"-DEOXYURIDINE
50-90-8
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 5-Chloro-2'-deoxyuridine
50-90-8
- $30.00-40.00
- 99.54%
- TargetMol Chemicals Inc.
-
- 5-CHLORO-2'-DEOXYURIDINE
50-90-8
- 98%
- Shaanxi Dideu New Materials Co. Ltd
-
- 5-CHLORO-2"-DEOXYURIDINE
50-90-8
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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