DBeQ
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- CAS-Nr.
- 177355-84-9
- Englisch Name:
- DBeQ
- Synonyma:
- JRF;DBeQ;JRF 12;CS-982;DBeQ (JRF 12);DBeQ USP/EP/BP;DBEQ, 10 mM in DMSO;JRF 12; JRF12; JRF-12;DBeQ, p97 ATPase inhibitor;N,N'-Dibenzylquinazoline-2,4-diamine
- CBNumber:
- CB02569682
- Summenformel:
- C22H20N4
- Molgewicht:
- 340.42
- MOL-Datei:
- 177355-84-9.mol
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DBeQ Eigenschaften
- Schmelzpunkt:
- 149 °C
- Siedepunkt:
- 573.1±52.0 °C(Predicted)
- Dichte
- 1.259±0.06 g/cm3(Predicted)
- storage temp.
- room temp
- Löslichkeit
- DMSO: ≥20mg/mL
- Aggregatzustand
- powder
- pka
- 7.78±0.30(Predicted)
- Farbe
- white to beige
- Stabilität:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
- InChI
- 1S/C22H20N4/c1-3-9-17(10-4-1)15-23-21-19-13-7-8-14-20(19)25-22(26-21)24-16-18-11-5-2-6-12-18/h1-14H,15-16H2,(H2,23,24,25,26)
- InChIKey
- QAIMUUJJAJBPCL-UHFFFAOYSA-N
- SMILES
- C(Nc1nc(NCc2ccccc2)c3ccccc3n1)c4ccccc4
- CAS Datenbank
- 177355-84-9
DBeQ Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
The ATPase p97 is an ubiquitin-selective chaperone known to play a critical role in the degradation of misfolded membrane and secretory proteins and has been linked to various cellular processes that require unfolding and disassembly of protein complexes. DBeQ is a selective, reversible, and ATP-competitive inhibitor of the ATPase p97 (Ki = 3.2 μM; IC50 = 1.5 μM). It does not exhibit activity when tested against a panel 170 protein kinases at concentrations as high as 15 μM. At 10 μM it blocks endoplasmic reticulum-associated degradation, impairing the autophagy pathway and promoting the activation of caspase-3 and -7 in cancer cells.[Cayman Chemical]
Biochem/physiol Actions
DBeQ is a potent and specific inhibitor of ATPase p97, an integral component of the ubiquitin-fusion degradation (UFD) pathway. DBeQ inhibits the degradation of ubiquitinated proteins, the endoplasmic reticulum-associated degradation pathway, and autophagosome maturation. The compound also potently inhibits cellular proliferation and induces caspase 3/7 activity and apoptosis.
DBeQ Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
DBeQ Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 154)Lieferanten
- DBeQ
- 2,4-QuinazolinediaMine, N2,N4-bis(phenylMethyl)-
- 2,4-QuinazolinediaMine, N,N'-bis(phenylMethyl)-
- JRF 12
- N,N'-Dibenzylquinazoline-2,4-diamine
- N2,N4-Dibenzylquinazoline-2,4-diamine
- JRF
- N,N'-Dibenzylquinazoline-2,4-diamine DBeQ
- N2,N4-Dibenzylquinazoline-2,4-diamine
DBeQ
- N,N'-Dibenzyl-2,4-quinazolinediamine, 99%
- N2,N4-Bis(phenylmethyl)-2,4-quinazolinediamine
- JRF 12; JRF12; JRF-12
- CS-982
- DBeQ (JRF 12)
- DBeQ USP/EP/BP
- N,N'-Dibenzyl-2,4-quinazolinediamine
- DBeQ, p97 ATPase inhibitor
- DBEQ, 10 mM in DMSO
- N2,N4-dibenzylquinolineazoleline-2,4-diamine
- 177355-84-9
- API
- Inhibitors
