DBeQ
- CAS No.
- 177355-84-9
- Chemical Name:
- DBeQ
- Synonyms
- JRF;DBeQ;JRF 12;CS-982;DBeQ (JRF 12);DBeQ USP/EP/BP;DBEQ, 10 mM in DMSO;JRF 12; JRF12; JRF-12;DBeQ, p97 ATPase inhibitor;N,N'-Dibenzylquinazoline-2,4-diamine
- CBNumber:
- CB02569682
- Molecular Formula:
- C22H20N4
- Molecular Weight:
- 340.42
- MDL Number:
- MFCD03691820
- MOL File:
- 177355-84-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 149 °C |
|---|---|
| Boiling point | 573.1±52.0 °C(Predicted) |
| Density | 1.259±0.06 g/cm3(Predicted) |
| storage temp. | room temp |
| solubility | DMSO: ≥20mg/mL |
| form | powder |
| pka | 7.78±0.30(Predicted) |
| color | white to beige |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months. |
| InChI | 1S/C22H20N4/c1-3-9-17(10-4-1)15-23-21-19-13-7-8-14-20(19)25-22(26-21)24-16-18-11-5-2-6-12-18/h1-14H,15-16H2,(H2,23,24,25,26) |
| InChIKey | QAIMUUJJAJBPCL-UHFFFAOYSA-N |
| SMILES | C(Nc1nc(NCc2ccccc2)c3ccccc3n1)c4ccccc4 |
| CAS DataBase Reference | 177355-84-9 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
DBeQ price More Price(70)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0031 | DBeQ ≥98% (HPLC) | 177355-84-9 | 5mg | $122 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML0031 | DBeQ ≥98% (HPLC) | 177355-84-9 | 25mg | $497 | 2026-04-30 | Buy |
| TCI Chemical | D5476 | DBeQ >98.0%(HPLC) | 177355-84-9 | 25mg | $75 | 2026-04-30 | Buy |
| TCI Chemical | D5476 | DBeQ >98.0%(HPLC) | 177355-84-9 | 100mg | $222 | 2026-04-30 | Buy |
| Cayman Chemical | 15318 | DBeQ ≥98% | 177355-84-9 | 5mg | $95 | 2026-04-30 | Buy |
DBeQ Chemical Properties, Uses, Production
Description
DBeQ (177355-84-9) is a potent, selective and reversible inhibitor of the AAA-ATPase p97 (ATPase associated with diverse cellular activities). Ki=3.2 μM. DBeQ blocks ubiquitin-dependent protein clearance pathways. Cell permeable.
Uses
The ATPase p97 is an ubiquitin-selective chaperone known to play a critical role in the degradation of misfolded membrane and secretory proteins and has been linked to various cellular processes that require unfolding and disassembly of protein complexes. DBeQ is a selective, reversible, and ATP-competitive inhibitor of the ATPase p97 (Ki = 3.2 μM; IC50 = 1.5 μM). It does not exhibit activity when tested against a panel 170 protein kinases at concentrations as high as 15 μM. At 10 μM it blocks endoplasmic reticulum-associated degradation, impairing the autophagy pathway and promoting the activation of caspase-3 and -7 in cancer cells.[Cayman Chemical]
Uses
HeLa cells were treated with DBeQ and the effects on in vivo ubiquitination and protein dislocation were studied by live cell imaging.
Biochem/physiol Actions
DBeQ is a potent and specific inhibitor of ATPase p97, an integral component of the ubiquitin-fusion degradation (UFD) pathway. DBeQ inhibits the degradation of ubiquitinated proteins, the endoplasmic reticulum-associated degradation pathway, and autophagosome maturation. The compound also potently inhibits cellular proliferation and induces caspase 3/7 activity and apoptosis.
storage
Store at +4°C
References
[1] TSUI-FEN CHOU. Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2011: 4834-4839. DOI:10.1073/pnas.1015312108
DBeQ Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2915 | 55 | |
| Jinan Trio PharmaTech Co., Ltd. | 0531-88811783 | sales@trio-pharmatech.com | China | 1856 | 62 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4765 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7545 | 61 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
| TCI Europe | 320-37350700 | sales@tcieurope.eu | Europe | 23654 | 75 |
| TCI AMERICA | 800-4238616 | sales@tciamerica.com | Americas | 23636 | 75 |
| SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD | 13816107857 | sales@fortunechem-sh.com | China | 981 | 58 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4853 | 58 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4773 | 55 |
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