Faropenem
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- CAS-Nr.
- 106560-14-9
- Englisch Name:
- Faropenem
- Synonyma:
- Faropenem sodium hemipentahydrate;FROPENEM;FAROPENEM;Faropenem Sodium Impurity G;Faropenem sodium hemi 5-hydrate;Faropenem sodium hemipentahydrate USP/EP/BP;6α-[(R)-1-hydroxyethyl]-2-[(R)-tetrahydrofuran-2-yl]pen-2-em-3-carboxylic acid;(5R,6S,8R,2'R)-2-(2'-tetrahydrofuryl)-6-(1-hydroxyethyl)-2-penem-3-carboxylic acid;6alpha-[(R)-1-hydroxyethyl]-2-[(R)-tetrahydrofuran-2-yl]pen-2-em-3-carboxylic acid;(5R,6S)-6-[(1R)-1-hydroxyethyl]-7-oxo-3-[(2R)-2-oxolanyl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
- CBNumber:
- CB1300660
- Summenformel:
- C12H15NO5S
- Molgewicht:
- 285.32
- MOL-Datei:
- 106560-14-9.mol
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Faropenem Eigenschaften
- Siedepunkt:
- 570.2±50.0 °C(Predicted)
- Dichte
- 1.56±0.1 g/cm3(Predicted)
- pka
- 4.00±0.40(Predicted)
- CAS Datenbank
- 106560-14-9
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
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P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizität (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P302+P352 |
BEI BERÜHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckmäßig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
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Faropenem Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Farom was launched in Japan for use as an antibiotic against common
respiratory tract pathogens. It can be prepared by several related routes of about
seven steps starting with tetrahydrofuran-2-thiocarboxylic acid and a silylated
azetidinone. It is a broad spectrum oral penem antibiotic that is β-lactamase stable.
Farom is the most active β-lactam against anaerobes (more than cefaclor, cefixime
and amoxicillin) but also has activity against Gram-positive, Gram-negative and
enterobacteriaceae. It is equally active against strains carrying plasmid and
chromosome mediated β-lactamases. The short plasma elimination half-life is the
result of hydrolysis by renal dehydropeptidase. It is more stable to hydrolysis by
extended spectrum β-lactamases than some second and third generation
cephalosporins.
Verwenden
Treatmentof bacterial infections.
Antimicrobial activity
An orally active penem with a broad spectrum of antibacterial
activity, including activity against selected anaerobic
pathogens. Although it is active against most enterobacteria, it has reduced activity against Ser. marcescens,
Enterobacter spp. and some Providencia spp. It generally
retains activity against many Gram-positive organisms,
but has no useful activity against Ps. aeruginosa. It has
reduced activity against E. faecium, methicillin-resistant
Staph. aureus (MRSA) and some strains of coagulase-negative
staphylococci. It is stable to hydrolysis by extended
spectrum β-lactamases, but is hydrolyzed by carbapenemases.
Esterified prodrugs with increased bioavailability
have been studied in clinical trials but have not received
regulatory approval.
Faropenem Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Faropenem Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 138)Lieferanten
106560-14-9()Verwandte Suche:
2-Ethyl-3-hydroxy-4H-pyran-4-on
Natriumsulfat
Natriumchlorid
Natriumacetat
Natriumbenzoat
Natriumhydrogencarbonat
Furazolidon
(o-(-2,6-Dichloranilino)phenyl)-essigsäure, Natrium-Salz
5-Chlorvaleriansaeure
Tetrahydrofuran
Natriumhydroxid
Trinatriumcitrat
4,4-Bis(4-hydroxyphenyl)valeriansure
Natriumchlorit
Pralmorelin
3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-ol
2-(Methylsulfonyl)ethanol
Dinatriumcarbonat, Verbindung mitHydrogenperoxid (2:3)
- (+)-(5R,6S)-6-[(1R)-1-Hydroxyethyl]-7-oxo-3-[(2R)-tetrahydro-2-furyl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
- (5R,6S,8R,2'R)-2-(2'-tetrahydrofuryl)-6-(1-hydroxyethyl)-2-penem-3-carboxylic acid
- 4-Thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 6-(1-hydroxyethyl)-7-oxo-3-(tetrahydro-2-furanyl)-, [5R-[3(R*),5α,6α(R*)]]-
- 4-Thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 6-[(1R)-1-hydroxyethyl]-7-oxo-3-[(2R)-tetrahydro-2-furanyl]-, (5R,6S)-
- 6-[(1R)-1-Hydroxyethyl]-7-oxo-3-[(2R)-tetrahydro-2-furanyl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid monosodium salt hemipentahydrate
- FAROPENEM
- FROPENEM
- [5R-[3(R^<*>^)，5α，6α(R^<*>^)]]-6-(1-hydroxyethyl)-7-oxo-3-(tetrahydro-2-furanyl)-4-thia-1-azobicyclo[3.2.0]leapt-2- ene-2-carboxylicacid
- (5R,6R)-6-[(1R)-1-hydroxyethyl]-7-oxo-3-[(2R)-tetrahydrofuran-2-yl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
- (5R,6S)-6-[(1R)-1-hydroxyethyl]-7-oxo-3-[(2R)-2-oxolanyl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
- (5R,6S)-6-[(1R)-1-hydroxyethyl]-7-keto-3-[(2R)-tetrahydrofuran-2-yl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
- (5R,6S)-6-[(1R)-1-hydroxyethyl]-7-oxo-3-[(2R)-oxolan-2-yl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
- 6alpha-[(R)-1-hydroxyethyl]-2-[(R)-tetrahydrofuran-2-yl]pen-2-em-3-carboxylic acid
- 6α-[(R)-1-hydroxyethyl]-2-[(R)-tetrahydrofuran-2-yl]pen-2-em-3-carboxylic acid
- Faropenem sodium hemipentahydrate USP/EP/BP
- (5R,6S)-6-((R)-1-Hydroxyethyl)-7-oxo-3-((R)-tetrahydrofuran-2-yl)-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
- Faropenem-d5Q: What is
Faropenem-d5 Q: What is the CAS Number of
Faropenem-d5 Q: What are the applications of
Faropenem-d5
- Faropenem sodium hemi 5-hydrate
- Faropenem Sodium Impurity G
- Faropenem sodium hemipentahydrate
- 106560-14-9
- 22547-49-3
- 2C12H14NNaO5S5H20
- 2C12H14NO5S2Na5H2O
- API
