Clofarabine
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- CAS-Nr.
- 123318-82-1
- Englisch Name:
- Clofarabine
- Synonyma:
- 200mg;Clolar;2-chloro-9-(2-deoxy-2-fluoroarabinofuranosyl)adenine;2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine;CAFDA; Clola;Evoltra;CS-1954;Clofarex;Clorabine
- CBNumber:
- CB2277491
- Summenformel:
- C10H11ClFN5O3
- Molgewicht:
- 303.68
- MOL-Datei:
- 123318-82-1.mol
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Clofarabine Eigenschaften
- Schmelzpunkt:
- 228-2310C
- Siedepunkt:
- 550.0±60.0 °C(Predicted)
- Dichte
- 1.4804 (estimate)
- RTECS-Nr.
- UD7473000
- storage temp.
- 2-8°C
- Löslichkeit
- DMSO: >10mg/mL
- Aggregatzustand
- Powder
- pka
- 12.56±0.70(Predicted)
- Farbe
- white
- Optische Rotation
- 40.9°(C=0.01g/ml DMF)
- maximale Wellenlänge (λmax)
- 263nm(EtOH)(lit.)
- Merck
- 14,2372
- InChI
- InChI=1/C10H11ClFN5O3/c11-10-15-7(13)5-8(16-10)17(2-14-5)9-4(12)6(19)3(1-18)20-9/h2-4,6,9,18-19H,1H2,(H2,13,15,16)/t3-,4+,6-,9-/s3
- InChIKey
- INHHKRVRRUIAPA-KJHIFWANSA-N
- SMILES
- C12N=C(N=C(N)C=1N=CN2[C@H]1[C@@H](F)[C@H](O)[C@@H](CO)O1)Cl |&1:10,11,13,15,r|
- CAS Datenbank
- 123318-82-1(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
T |
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| R-Sätze: |
25 |
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| S-Sätze: |
45 |
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| RIDADR |
UN 2811 6.1 / PGIII |
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| WGK Germany |
2 |
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| HazardClass |
6.1 |
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| HS Code |
29349990 |
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| Speicherklasse |
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects |
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| Hazard Classifications |
Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Carc. 2
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
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| Bildanzeige (GHS) |
 
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
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P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizität (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
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| H351 |
Kann vermutlich Krebs verursachen. |
Karzinogenität |
Kategorie 2 |
Warnung |
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P201, P202, P281, P308+P313, P405,P501 |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
| P308+P313 |
BEI Exposition oder falls betroffen: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen. |
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Clofarabine Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
White Solid
Verwenden
Clofarabine has been used in a cell viability assay to analyze the sensitivity of the isogenic cell lines towards clofarabine. It is also used to study the interaction of anticancer drug clofarabine with human serum albumin and human α-1 acid glycoprotein.
Definition
ChEBI: A purine nucleoside analogue consisting of a 6-amino-2-chloropurin-9-yl group attached to the 1beta position of 2'-deoxy-2'-fluoro-D-arabinofuranose. It is metabolized intracellularly to the active 5'-triphosphate metaboli
e, which inhibits DNA synthesisis and so stops the growth of cancer cells. Clofarabine is used as an antimetabolite antineoplastic agent in the treatment of relapsed or refractory acute lymphoblastic leukaemia.
Biologische Aktivität
Deoxycytidine kinase (dCK) substrate. Phosphorylated to form clofarabine triphosphate, which competes with dATP for DNA polymerase- α and - ε and potently inhibits ribonucleotide reductase (IC 50 = 65 nM). Induces apoptosis by directly altering mitochondrial transmembrane potential. Demonstrates growth inhibition and cytotoxic activity in a variety of leukemias and solid tumors.
Clofarabine Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Clofarabine Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 480)Lieferanten
123318-82-1()Verwandte Suche:
- 2-CHLORO-2'-ARABINOFLUORO-2'-DEOXYADENOSINE
- 5-(6-amino-2-chloro-purin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol
- CLOFARABINE
- CAFDA
- 2-chloro-9-(2-deoxy-2-fluoroarabinofuranosyl)adenine
- 2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofuranosyl)-9h-purin-6-amin
- 2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofuranosyl)adenine
- Clolar
- Clofarabine2-CHLORO-9-(2'-DEOXY-2'-FLUORO-B-D-ARABINOFURANOSYL)ADENINE
- 5-(6-amino-2-chloro-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)tetrahydrofuran-3-ol
- 6-AMino-2-chloropurine -9-beta-D-(2'-deoxy-2'-fluoro)-arabinoriboside
- Clofarabine, 98%, a ribonucleotide reductase inhibitor
- Clola
- 2-Chloro-9-(2-deoxy-2-fluoro-b-D-arabinofuranosyl)-9H-purin-6-amine
- 9H-Purin-6-amine, 2-chloro-9-(2-deoxy-2-fluoro-b-D-arabinofuranosyl)-
- CLOFARABINE(FORR&DONLY)
- CLOFARABINE, 5-(6-AMINO-2-CHLORO-PURIN-9-YL)-4-FLUORO-2-(HYDROXYMETHYL)OXOLAN-3-OL
- CLORFARABINE
- (2R,3R,4S,5R)-5-(6-amino-2-chloro-purin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol
- 9H-Purin-6-amine, 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-
- 2-CHLORO-9-(2-DEOXY-2-FLUORO-β-D-ARABINOFURANOSYL)-9H-PURIN-6-AMINE (CLOFARABINE)
- 2-Chloro-9-(2-deoxy-2-fluoro--D-arabinofuranosyl)-9H-purin-6-amine
- 50MG/200MG/100G
- 2-Chloro-6-aMino-purine-2'-fluoro-2'- deoxy arabin
- 200mg
- (2R,3R,4S,5R)-5-(6-aMino-2-chloro-9H-purin-9-yl)-4-fluoro-2-(hydroxyMethyl)oxolan-3-ol
- Clofarabine, Free Base
- Clofarex
- Evoltra
- 6-Amino-2-chloro-9-(2'-deoxy-2'-fluoro-b-D-arabinofuranosyl)purine
- CLOLAR CLOFARABINE
- (2R,3R,4S,5R)-5-(6-Amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol, 2-Chloro-2-arabino-fluoro-2-deoxyadenosine
- 6-AMino-2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purine
- Clofarabine-13C1-15N3
- CS-1954
- Clofarabine >
- (2R,3R,4S,5R)-5-(6-Amino-2-chloro-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)tetrahydrofuran-3-ol
- 6-Amino-2-chloropurine -9-beta-D-(2’-deoxy-2’-fluoro)-arabinoriboside, clofarabine
- 6-Amino-2-chloropurine-9-β-D-(2’-deoxy-2’-fluoro)arabinoriboside
- Clofarabine USP/EP/BP
- 2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine
- Antitumor drugs Clofarabine
- ClofarabineQ: What is
Clofarabine Q: What is the CAS Number of
Clofarabine Q: What is the storage condition of
Clofarabine Q: What are the applications of
Clofarabine
- Clorabine
- Clofarabine (100 mg)
- Precision Clofarabine
- Clofarabine, 10 mM in DMSO
- CAS:123318-82-1
- Clofarabine System Suitability Mixture
- Clofarabine - Bio-X ?
- Clofarabine/Clolar/Clofarex
- 123318-82-1
- 23318-82-1
- C10H11ClFN5O3
- Antineoplastic
- Anti-cancer&immunity
- Pharmaceutical intermediate
- CLOLAR
