Flubendazol
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- CAS-Nr.
- 31430-15-6
- Bezeichnung:
- Flubendazol
- Englisch Name:
- Flubendazole
- Synonyma:
- FLUBENDAZOL;Flubendazole Polymorph B;R-17899;R 17889;FLUMOXAL;FLUBENOL;FLUVERNAL;FLUMOXANE;fluvermal;Flubenvet
- CBNumber:
- CB2669630
- Summenformel:
- C16H12FN3O3
- Molgewicht:
- 313.28
- MOL-Datei:
- 31430-15-6.mol
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Flubendazol Eigenschaften
- Schmelzpunkt:
- 290°C
- Dichte
- 1.3720 (estimate)
- storage temp.
- 2-8°C
- Löslichkeit
- Practically insoluble in water, in alcohol and in methylene chloride
- pka
- 10.66±0.10(Predicted)
- Aggregatzustand
- Solid
- Farbe
- White to Off-White
- Merck
- 14,4118
- CAS Datenbank
- 31430-15-6(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| R-Sätze: |
22 |
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| S-Sätze: |
44 |
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| WGK Germany |
2 |
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| RTECS-Nr. |
DD6497500 |
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| HS Code |
29339900 |
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| Toxizität |
LD50 in mice, rats, guinea pigs (mg/kg): >2560 orally (Thienpont) |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H361 |
Kann vermutlich die Fruchtbarkeit beeinträchtigen oder das Kind im Mutterleib schädigen. |
Reproduktionstoxizität |
Kategorie 2 |
Warnung |
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P201, P202, P281, P308+P313, P405,P501 |
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| Sicherheit |
| P201 |
Vor Gebrauch besondere Anweisungen einholen. |
| P202 |
Vor Gebrauch alle Sicherheitshinweise lesen und verstehen. |
| P281 |
Vorgeschriebene persönliche Schutzausrüstung verwenden. |
| P308+P313 |
BEI Exposition oder falls betroffen: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen. |
| P405 |
Unter Verschluss aufbewahren. |
| P501 |
Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Flubendazol Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Flubendazole is a benzimidazole carbamate anthelmintic. It completely eliminates larvae in a mouse model of
A. cantonensis infection and exhibits a mean larval reduction of 100% in a
T. spiralis infection model when administered at doses of 5 and 50 mg/kg per day, respectively. Flubendazole inhibits mammalian tubulin polymerization (IC
50 = 2.5 μM) and inhibits binding of [
3H]mebendazole to
H. contortus L3 larval tubulin (IC
50 = 0.17 μM). Flubendazole also inhibits the proliferation of BT-549, SK-BR-3, MDA-MB-231, and MCF-7 breast cancer cells (IC
50s = 0.72, 1.51, 1.75, and 5.51 μM, respectively) and reduces tumor growth in an MDA-MB-231 mouse xenograft model when administered at a dose of 25 mg/kg.
Chemische Eigenschaften
White Solid
Verwenden
An anthelmintic.
Definition
ChEBI: A member of the class of mebendazole in which the benzoyl group is replaced by a p-fluorobenzoyl group. A broad-spectrum anthelmintic, it is used, particularly in veterinary medicine, for the treatment of nematodal infections.
Allgemeine Beschreibung
Flubendazol is a broad spectrum anthelmintic, which belongs to the class of compounds known as benzimidazoles. It can be widely used in veterinary and human medicine. It mainly finds applications in deworming poultry, swine, dogs and cats.
Flubendazol Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Flubendazol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 454)Lieferanten
31430-15-6(Flubendazol)Verwandte Suche:
- METHYL [5-(4-FLUOROBENZOYL)-1H-BENZIMIDAZOL-2-YL]CARBAMATE
- CARBAMIC ACID, [5-(4-FLUOROBENZOYL)-1H-BENZIMIDAZOL-2-YL]-METHYL ESTER
- FLUMOXAL
- FLUMOXANAL
- FLUMOXANE
- FLUBENDAZOL
- FLUBENDAZOLE
- FLUBENOL
- FLUVERNAL
- [5-(4-FLUOROBENZOYL)-1H-BENZIMIDAZOL-2-YL]CARBAMIC ACID, METHYL ESTER
- (5-(4-fluorobenzoyl)-1h-benzimidazol-2-yl)-carbamicacimethylester
- (5-(4-fluorobenzoyl)-1h-benzimidazole-2-yl)carbamicacidmethylester
- [5-(4-Fluorobenzoyl)benzimidazol-2-yl]carbamic Acid Methyl Ester
Methyl [5-(4-Fluorobenzoyl)benzimidazol-2-yl]carbamate
- Flubendazole (FlutelMiuM)
- flubendazole Solution, 100ppm
- Flubendazole Imp. (EP)
- Flubendazol, >=99%
- Flubendazole Polymorph B
- [5-(4-Fluorobenzoyl)benzimidazol-2-yl]carbamic Acid Methyl Ester
- Methyl [5-(4-Fluorobenzoyl)benzimidazol-2-yl]carbamate
- N-[6-[(4-fluorophenyl)-oxomethyl]-1H-benzimidazol-2-yl]carbamic acid methyl ester
- 5-(p-fluorobenzoyl)-2-benzimidazolecarbamicacimethylester
- fluvermal
- methyln-(5-(p-fluorobenzoyl)-2-benzimidazolyl)carbamate
- 5-(p-fluorobenzoyl)-2-benzimidazolecarbamic acid methyl este
- [5-(4-fluorobenzoyl)-1H-benzimidazol-2-yl]-,methyl ester
- Flumoxanal, Methyl [5-(4-fluorobenzoyl)-1H-benzimidazol-2-yl]carbamate
- 5-(p-Fluorobenzoyl)-1H-benzimidazole-2-carbamic acid methyl ester
- R-17899
- 5-(p-Fluorobenzoyl)-2-benzimidazolecarbamic acid, Methyl ester
- flubendazole standard
- Methyl (5-(4-fluorobenzoyl)-1H-benzo[d]iMidazol-2-yl)carbaMate
- Flubenvet
- Methyl (5-p-Fluorobenzoyl-2-benziMidazolyl)carbaMate
- N-[6-(4-Fluorobenzoyl)-1H-benziMidazol-2-yl]carbaMic Acid Methyl Ester
- NSC 313680
- R 17889
- Flubendazole PolyMorph B COS
- Flubendazole for system suitability CRS
- Flubendazole CRS
- Flubendazole>
- ubendazoL
- Carbamic acid, N-[6-(4-fluorobenzoyl)-1H-benzimidazol-2-yl]-, methyl ester
- Flubendazole Solution in DMSO, 1000μg/mL
- Flubendazole USP/EP/BP
- Flubendazole EP
- Flumoxanal|||Flumoxane|||NSC 313680|||Fluvermal
- Flubendazole in methanol
- Flubendazole in DMSO
- Flubendazole 100 μg/ml Acetonitrile
- C13678000 Flubendazole
- Flubendazole in Acetonitrile:DMF=1:1
- Flubendazole, 10 mM in DMSO
- Fluorophenyl Imidazole
- Flubendazole (NSC 313680, NSC313680)
- 31430-15-6
- C16H12FN3O3
- C16H12N3O3F
