Methylprednisolon Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
White to Off-White Crystalline Powder
Definition
ChEBI: The 6alpha-stereoisomer of 6-methylprednisolone.
Allgemeine Beschreibung
Methylprednisolone, 11β,17,21-trihydroxy-6α-methyl-1,4-pregnadiene-3,20-dione, isavailable unmodified or as ester derivatives.
Methylprednisolone acetate, USP
Methylprednisolone sodium succinate, USP.
Mechanism of action
Methylprednisolone is an analog of prednisolone that exhibits a more prolonged effect
than prednisolone and cortisone; it has practically no mineralocorticosteroid activity and
is better tolerated.
Clinical Use
Adding a 6α-methyl group to prednisolone increases the glucocorticoid activity and effectively
abolishes mineralocorticoid action. It has fivefold the glucocorticoid activity of hydrocortisone
(prednisolone has fourfold the glucocorticoid activity) and none of its mineralocorticoid
properties. It is used almost exclusively as a systemic product and is available as the free alcohol
for oral administration and as various esters.
Sicherheitsprofil
Moderately toxic by
intraperitoneal route. A steroid hormone.
Human systemic effects include arrhythmias,
blood pressure lowering, heart rate changes,
increased body temperature, pulse rate
increase, respiratory depression. When heated to decomposition it emits acrid
smoke and irritating fumes.
läuterung methode
Recrystallise medrol from EtOAc. The UV has max at in 95% EtOH 243nm ( 14,875). The 21-acetoxy derivative has m 205-208o (from EtOAc), and [] D +95o ( c 1, CHCl3). [Spero et al. J Am Chem Soc 78 6213 1956; Fried et al. J Am Chem Soc 81 1235 1959; 1H NMR: Slomp & McGarvey J Am Chem Soc 81 2200 1959, Beilstein 8 IV 3498.]
Methylprednisolon Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
