Fingolimod hydrochloride

Fingolimod hydrochloride Struktur
162359-56-0
CAS-Nr.
162359-56-0
Englisch Name:
Fingolimod hydrochloride
Synonyma:
FTY720;Fingolimod HCl;Gilenya;2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride;Fin;FTY720 . HCl;Fingolimod HC;FingoliMod FTY120;limod hydrochloride;FTY720 HYDROCHLORIDE
CBNumber:
CB4244536
Summenformel:
C19H34ClNO2
Molgewicht:
343.93
MOL-Datei:
162359-56-0.mol

Fingolimod hydrochloride Eigenschaften

Schmelzpunkt:
102-107°C
storage temp. 
-20°C
Löslichkeit
water: soluble10mg/mL, clear
Aggregatzustand
powder
Farbe
white to beige
Biologische Quelle
synthetic
Wasserlöslichkeit
water: 10mg/mL, clear
Merck 
14,4083
Stabilität:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChI
InChI=1S/C19H33NO2.ClH/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)13-14-19(20,15-21)16-22;/h9-12,21-22H,2-8,13-16,20H2,1H3;1H
InChIKey
SWZTYAVBMYWFGS-UHFFFAOYSA-N
SMILES
C1(C=CC(CCCCCCCC)=CC=1)CCC(N)(CO)CO.Cl
CAS Datenbank
162359-56-0(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xi
R-Sätze: 36/37/38-52/53
S-Sätze: 26-61
WGK Germany  3
RTECS-Nr. TY3130000
HS Code  29221990
Speicherklasse 11 - Combustible Solids
Hazard Classifications STOT RE 2
Toxizität LD50 orally in rats: 300-600 mg/kg (Troncoso)
Bildanzeige (GHS) Health Hazard (GHS08)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H373 Kann die Organe schädigen bei längerer oder wiederholter Exposition. Spezifische Zielorgan-Toxizität (wiederholte Exposition) Kategorie 2 Warnung P260, P314, P501
Sicherheit
P260 Dampf/Aerosol/Nebel nicht einatmen.
P314 Bei Unwohlsein ärztlichen Rat einholen / ärztliche Hilfe hinzuziehen.
P501 Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Fingolimod hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Approved by the U.S. FDA in September 2010, fingolimod (also referred to as FTY720) is the first approved oral therapy for the relapsing-remitting form ofmultiple sclerosis (RRMS). Because of fingolimod’s structural resemblance to sphingosine, a metabolite of sphingolipids that constitutes the cell membrane of all eukaryotic cells, it was hypothesized that fingolimod may be affecting sphingolipid metabolism in cells. A series of elegant in vitro and in vivo studies confirmed that fingolimod is converted to (S)-fingolimod phosphate primarily by sphingosine kinase- 2 and that (S)-fingolimod phosphate mediates multiple biological processes by binding to novel GPCR’s referred to as sphingosine-1-phosphate (S1P) receptors. S1P receptors are divided into five subtypes, S1P1–5, which have varying tissue and cellular distribution. S1P1–3 receptors are ubiquitously expressed in the immune, cardiovascular, and central nervous systems, S1P4 is restricted to the hematopoietic system, and S1P5 is mostly localized in the white matter of CNS. S1P1–3 receptors play important roles in endothelial barrier function, maintaining vascular tone, regulating heart rate and allowing for lymphocyte egress fromsecondary lymphoid organs. The functional role of S1P4 is unknown,while the S1P5 receptor is thought to be involved in natural killer cell trafficking and oligodendrocyte function.

Chemische Eigenschaften

White Solid

Verwenden

Fingolimod Hydrochloride is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analogue of Sphingosine. Fingolimod is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs. Fingolimod is reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPgS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively).

Definition

ChEBI: The hydrochloride salt of 2-amino-2-[2-(4-octylphenyl) ethyl]-1,3-propanediol (fingolimod).

Clinical Use

Fingolimod hydrochloride is an immunosuppressive drug developed by Novartis and approved in the U.S., Europe, and Australia in 2010 for the treatment of multiple sclerosis. The structure of fingolimod derives from the naturally-occurring myriocin (ISP-1) metabolite of the fungus I. sinclairii and the aminoalcohol functionality within the drug possesses structural similarity to the sphingosine family of natural products.

Fingolimod hydrochloride Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Fingolimod hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 493)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shijiazhuang Dingmin Pharmaceutical Sciences Co., Ltd.
+86-86-311-67591193 13931880626
sales02@dingminpharma.com China 305 58
Hebei Chuanghai Biotechnology Co., Ltd
+8615350571055
Sibel@chuanghaibio.com China 8738 58
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
+86-18600796368
sales@sjar-tech.com China 529 58
Shaanxi Xianhe Biotech Co., Ltd
+86-17709210191; +8617709210191
Jerry@xhobio.com China 906 58
Hebei Zhuanglai Chemical Trading Co Ltd
+86-16264648883
niki@zlchemi.com China 7245 58
Capot Chemical Co.,Ltd.
+86-(0)57185586718 +86-13336195806
sales@capot.com China 29640 60
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21586 55
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 33024 60
Lianyungang happen teng technology co., LTD
15950718863
wang666xt@163.com CHINA 295 58
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29812 58

162359-56-0()Verwandte Suche:


  • fingolimod hydrochloride
  • FingoliMod (FTY720) HCl
  • 2-(4-octylphenethyl)-2-aminopropane-1,3-diol hydrochloride
  • 2-Amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride Fingolimod (FTY720) HCl
  • Fingolimod hydrochloride 2-Amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride
  • Fingolimod (FTY-720A, FTY720)
  • FTY-720A
  • 1,3-Propanediol, 2-amino-2-(2-(4-octylphenyl)ethyl)-, hydrochloride
  • Unii-G926ec510t
  • FTY720(Fingolimod)
  • FY720
  • FTY720 B-0720
  • Fingolimod hydrochloride(FTY720)
  • FTY720(FingoliMod HCL)
  • Fingolimod hydrochlorid
  • 2-aMino-2-(4-octylphenethyl)propane-1,3-diol hydrochloride
  • Gilenya
  • Fingolimod hydrochloride, 98%, S1P antagonist
  • FTY720 hydrochloride, >=99%
  • Fingolimod HLC
  • GILENIA;FTY720;FTY 720
  • CS-290
  • Fingolimod hydrochloride CRS
  • FingolimodHydrochloride>
  • Fingolimod Hydrochloride (300 mg)
  • 1,3-Propanediol, 2-amino-2-[2-(4-octylphenyl)ethyl]-, hydrochloride (1:1)
  • 2-Amino-2-[2-(4-n-octylphenyl)ethyl]propane-1,3-diol Hydrochloride
  • Fingolimod hydrochloride USP/EP/BP
  • Tianfu Chem Fingolimod
  • Phingomode hydrochloride
  • Fingolimod (FTY720), S1P receptor modulator
  • Fingolimod hydrochloride, 10 mM in DMSO
  • FINGOLIMOD HYDROCHLORIDE NON-STERILE BULK DRUG SUBSTANCE
  • FINGOLIMOD HYDROCHLORIDE USP
  • Fingolimod HCl - Bio-X ?
  • FTY720【SML0700】
  • 2-Amino-2-(4-octylphenethyl)-propan-1,3-diol HCl
  • 2-AMINO-2-[2-(4-OCTYLPHENYL)ETHYL]-1,3-PROPANEDIOL, HYDROCHLORIDE
  • 2-Amino-2-(2-(4-octylphenyl)ethyl)propane-1,3-diol,HCl
  • 2-AMINO-2-[2-(4-OCTYLPHENYL)-ETHYL]-1,3-PROPANEDIOL
  • 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride
  • Fingolimod (FTY720) hydrochloride
  • Fin
  • Fingolimod HCL(FTY720)
  • FingoliMod FTY120
  • Fingolimod HC
  • Fingolimod HCl
  • FTY720 HYDROCHLORIDE
  • FTY720 . HCl
  • FTY720
  • limod hydrochloride
  • 162359-56-0
  • 62359-55-9
  • C19H34ClNO2
  • C19H33NO2HCl
  • Pharmaceuticals
  • Aromatics
  • Intermediates & Fine Chemicals
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