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Oligomycin A, 12-Deoxy-

OLIGOMYCIN C Struktur
11052-72-5
CAS-Nr.
11052-72-5
Bezeichnung:
Oligomycin A, 12-Deoxy-
Englisch Name:
OLIGOMYCIN C
Synonyma:
OLIGOMYCIN C;Oligmycin C;12-Deoxyoligomycin A;Oligomycin A, 12-deoxy-;OLIGOMYCIN C, STREPTOMYCES DIASTATOCHROMOGENES;Spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-[2H]pyran]-3,9,13-trione,22-ethyl-3',4',5',6'-tetrahydro-7,11,15-trihydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-,(1R,2'R,4E,5'S,6S,6'S,7R,8S,10R,11R,12S,14S,15S,16R,18E,20E,22R,25S,28S,29R)-;Spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-[2H]pyran]-3,9,13-trione, 22-ethyl-3',4',5',6'-tetrahydro-7,11,15-trihydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-, (1R,2'R,4E,5'S,6S,6'S,7R,8S,10R,11S,12S,14S,15S,16R,18E,20E,22R,25S,28S,29R)-
CBNumber:
CB4354053
Summenformel:
C45H74O10
Molgewicht:
775.06
MOL-Datei:
11052-72-5.mol
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Oligomycin A, 12-Deoxy- Eigenschaften

Siedepunkt:
876.2±65.0 °C(Predicted)
Dichte
1.091 g/cm3
storage temp. 
−20°C
Löslichkeit
Soluble in DMSO
Aggregatzustand
White to off-white powder.
pka
13.49±0.70(Predicted)
Merck 
13,6902
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xn
R-Sätze: 22
RIDADR  2811
RTECS-Nr. RK3335000
HazardClass  6.1(b)
PackingGroup  III
HS Code  2941900000
Toxizität LD50 ipr-mus: 8300 mg/kg JACSAT 80,6092,1958
Bildanzeige (GHS) Exclamation Mark (GHS07)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P271 Nur im Freien oder in gut belüfteten Räumen verwenden.

Oligomycin A, 12-Deoxy- Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R22:Gesundheitsschädlich beim Verschlucken.

Beschreibung

Oligomycins are macrolides created by Streptomyces species that can be toxic to other organisms. Different oligomycin isomers are highly specific for the disruption of mitochondrial metabolism. Oligomycin C is a minor component of the oligomycin complex that acts as an inhibitor of the mitochondrial F1FO-ATP synthase. Inhibition of the ATP synthase by oligomycins leads to cell death.

Verwenden

Oligomycin C, a minor component of the oligomycin complex isolated from selected strains of Streptomyces, is an inhibitor of mitochondrial F1F0-ATPase. It makes cells more susceptible to cell death, and also leads to a switch in the death mode from apoptosis to necrosis.

Sicherheitsprofil

A poison by intraperitoneal route.When heated to decomposition it emits acrid smoke andirritating vapors

Oligomycin A, 12-Deoxy- Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Oligomycin A, 12-Deoxy- Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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11052-72-5(Oligomycin A, 12-Deoxy-)Verwandte Suche:

3-Chlor-2-methylpropen Glutathion Oligomycin A Oligomycin Oligomycin A, 28-Oxo- Oligomycin A, 12-Deoxy-
  • 12-Deoxyoligomycin A
  • Oligmycin C
  • OLIGOMYCIN C
  • OLIGOMYCIN C, STREPTOMYCES DIASTATOCHROMOGENES
  • Oligomycin A, 12-deoxy-
  • Spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-[2H]pyran]-3,9,13-trione, 22-ethyl-3',4',5',6'-tetrahydro-7,11,15-trihydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-, (1R,2'R,4E,5'S,6S,6'S,7R,8S,10R,11S,12S,14S,15S,16R,18E,20E,22R,25S,28S,29R)-
  • Spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-[2H]pyran]-3,9,13-trione,22-ethyl-3',4',5',6'-tetrahydro-7,11,15-trihydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-,(1R,2'R,4E,5'S,6S,6'S,7R,8S,10R,11R,12S,14S,15S,16R,18E,20E,22R,25S,28S,29R)-
  • 11052-72-5
  • 11053-72-5
  • C45H74O10
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