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Pentagastrin

PENTAGASTRIN Struktur
5534-95-2
CAS-Nr.
5534-95-2
Bezeichnung:
Pentagastrin
Englisch Name:
PENTAGASTRIN
Synonyma:
GRP;HSPA;HS71A;ay6608;ici50123;petavlon;peptavlon;petogasrin;lanineamide;PENTAGASTRIN
CBNumber:
CB4412263
Summenformel:
C37H49N7O9S
Molgewicht:
767.9
MOL-Datei:
5534-95-2.mol
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Pentagastrin Eigenschaften

Schmelzpunkt:
229-230° (dec)
alpha 
D22 -28.8 ±0.5° (DMF)
Siedepunkt:
1196.6±65.0 °C(Predicted)
Dichte
1.303±0.06 g/cm3(Predicted)
storage temp. 
-20°C
Löslichkeit
Practically insoluble in water; soluble in 5M ammonia and in dimethylformamide; slightly soluble in ethanol (96%).
pka
4.19±0.10(Predicted)
Aggregatzustand
powder
Farbe
White to off-white
Sequenz
N-t-Boc-β-Ala-Trp-Met-Asp-Phe-NH2
InChIKey
NEYNJQRKHLUJRU-DZUOILHNSA-N
SMILES
C(C1=CNC2C=CC=CC1=2)[C@H](NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N)CC1C=CC=CC=1 |&1:10,27,35,43,r|

Sicherheit

Kennzeichnung gefährlicher T
R-Sätze: 61-36/38-20/21
S-Sätze: 53-45-36/37/39-22
WGK Germany  1
RTECS-Nr. AY2970000
Giftige Stoffe Daten 5534-95-2(Hazardous Substances Data)

Pentagastrin Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R61:Kann das Kind im Mutterleib schädigen.
R36/38:Reizt die Augen und die Haut.
R20/21:Gesundheitsschädlich beim Einatmen und bei Berührung mit der Haut.

S-Sätze Betriebsanweisung:

S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S22:Staub nicht einatmen.

Beschreibung

Pentagastrin is a synthetic polypeptide and cholecystokinin-2 (CCK2) receptor agonist. It binds selectively to CCK2 receptors in guinea pig brain over CCK1 receptors in rat pancreas (IC50s = 11 and 1,100 nM, respectively). Pentagastrin increases calcium influx and polyphosphoinositide turnover in rat GH3 pituitary cells (EC50s = 23 and 3.9 nM, respectively). It also increases histidine decarboxylase activity in mucous- and endocrine cell-enriched isolated rabbit fundic mucosal cells (EC50 = 2.9 nM). Pentagastrin induces contraction of isolated pig ileum smooth muscle cells in vitro (EC50 = 30 pM). It increases gastric acid and pepsin secretion in conscious cats in vivo (ED50s = 1.29 and 57.3 nmol/kg2 per hour, respectively). Formulations containing pentagastrin have previously been used as a diagnostic aid to evaluate gastric acid secretory function.

Chemische Eigenschaften

A white or almost white powder.

Verwenden

Pentagastrin is a synthetic polypeptide that has effects like gastrin when given parenterally. It stimulates the secretion of gastric acid, pepsin, and intrinsic factor, and has been used as a diagnostic aid as the pentagastrin-stimulated calcitonin test.

Allgemeine Beschreibung

Pentagastrin (Peptavlon), a physiologicalgastric acid secretagogue, is the synthetic pentapeptide derivative:N-t-butyloxycarbonyl-β-alanyl-L-tryptophyl-L-methionyl-L-aspartyl-L-phenylalanyl amide. It contains theCOOH-terminal tetrapeptide amide (H·Try·Met· Asp·Phe·NH2), which is considered to be the active center ofthe natural gastrins. Accordingly, pentagastrin appears tohave the physiological and pharmacological properties ofthe gastrins, including stimulation of gastric secretion,pepsin secretion, gastric motility, pancreatic secretion ofwater and bicarbonate, pancreatic enzyme secretion, biliaryflow and bicarbonate output, intrinsic factor secretion, andcontraction of the gallbladder.
Pentagastrin is indicated as a diagnostic agent to evaluategastric acid secretory function, and it is useful in testing foranacidity in patients with suspected pernicious anemia, atrophicgastritis or gastric carcinoma, hypersecretion in suspectedduodenal ulcer or postoperative stomal ulcers, andZollinger-Ellison tumor.

Pentagastrin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

β-Alanin N-[(tert-Butoxy)carbonyl]-D-tryptophan Protective agent Propionamid L-ASPARTIC ACID

Downstream Produkte

Pentagastrin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 216)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
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 jiuyitime@fdachem.com China 9029 58
Rixing Chemical CO.,LTD 		+86-13237129059 -13237129059
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5534-95-2(Pentagastrin)Verwandte Suche:

Terlipressin Lypressin Ornipressin Sucralfat Pentagastrin
  • T-BOC-BETA-ALA-TRP-MET-ASP-PHE-NH2
  • aspartyl]-l-phenylalaninamide
  • ay6608
  • boc-beta-ala-try-met-asp-phe(nh2)
  • gastrodiagnost
  • ici50123
  • lanineamide
  • l-methionyl-l-alpha-aspartyl-
  • l-n-tert-butyleste
  • n-((1,1-dimethylethoxy)carbonyl)-beta-alanyl-l-tryptophyl-l-phenylalaninamid
  • Acetyl-L-glutamic acid &gamma
  • Z-N-methyl-L-glutamic acid &gamma
  • N-(Benzyloxycarbonyl)-L-glutamic Acid &alpha
  • Fmoc-L-alpha-aminoadipic acid &delta
  • Fmoc-N-methyl-L-glutamic acid &gamma
  • Methotrexate &alpha
  • petogasrin
  • -tert-butylester
  • ylpropionamido]-4-(methylthio)butyramido]succinamicacidn-tert-butylester
  • n-t-boc-β-ala-trp-met-asp-phe amide
  • N-T-boc-B-ala-trp-met-asp-phe amide
  • PENTAGASTRIN (ICI 50123) SYNTHETIC >99%
  • BOC-β-Ala-Trp-Met-Asp-Phe-NH2
  • N-(1,1-Dimethylethoxy)carbonyl-βAla-L-Trp-L-Met-L-Asp-L-Phe-NH2
  • N-Boc-βAla-L-Trp-L-Met-L-Asp-L-Phe-NH2
  • AY 6608, ICI 50123, NSC 367746, Boc-(b-Ala13)-Gastrin (13-17), Boc-b-Ala-CCK-4
  • Boc-b-Ala-Trp-Met-Asp-Phe-NH2
  • 3-7-Cholecystokinin-7(swine), 3-[N-[(1,1-dimethylethoxy)carbonyl]-b-alanine]- (9CI)
  • L-Glutamic Acid &alpha
  • DL-Glutamic acid &gamma
  • N-tert-Butyloxycarbonyl-L-aspartic Acid &beta
  • Pentagastrin, ≥95%(HPLC)
  • n-(alpha-carbamoylphenethyl)-3-[2-[2-[3-(carboxyamino)propionamido]-3-indol-3-
  • n-[n-[n-[n-(n-tert-butoxycarbonyl-beta-alanyl)-l-tryptophanyl]-l-methionyl]-l-
  • n-carboxy-beta-alanyl-l-tryptophyl-l-methionyl-l-aspartylphenyl-alaninamid
  • n-carboxy-beta-alanyl-l-tryptophyl-l-methionyl-l-aspartylphenyl-l-alaninamiden
  • n-t-butyloxycarbonyl-beta-alanyl-l-tryptophyl-l-methionyl-l-aspartyl-l-phenyla
  • peptavlon
  • petavlon
  • Boc-(β-Ala13)-Gastrin (13-17)
  • GRP
  • GASTRIN RELEASING PEPTIDE
  • BOC-BETA-ALA-TRP-MET-ASP-PHE-NH2
  • PENTAGASTRIN
  • N-T-BOC-BETA-ALA-TRP-MET-ASP-PHE AMIDE
  • Z-L-beta-Glutamic acid &gamma
  • Fmoc-L-aspartic Acid &beta
  • Pehtagastrin
  • L-Phenylalaninamide, N-[(1,1-dimethylethoxy)carbonyl]-β-alanyl-L-tryptophyl-L-methionyl-L-α-aspartyl-
  • PENTAGASTRIN USP/EP/BP
  • (10S,13S,16S)-10-((1H-Indol-3-yl)methyl)-16-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)carbamoyl)-2,2-dimethyl-13-(2-(methylthio)ethyl)-4,8,11,14-tetraoxo-3-oxa-5,9,12,15-tetraazaoctadecan-18-oic acid
  • Pentagastrin, 10 mM in DMSO
  • HSPA
  • HS71A
  • 5534-95-2
  • C37H49N7O9S
  • C37H50N7O9S
  • Gastrointestinal Products
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