Methyl-N5-[imino(nitroamino)methyl]-L-ornithinmonohydrochlorid

Methyl-N5-[imino(nitroamino)methyl]-L-ornithinmonohydrochlorid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-Sätze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

Beschreibung

L-NAME requires hydrolysis of the methyl ester by cellular esterases to become a fully functional inhibitor (L-NNA). L-NNA exhibits some selectivity for inhibition of neuronal and endothelial isoforms. It exhibits K_i values of 15 nM, 39 nM, and 4.4 μM for nNOS (bovine), eNOS (human), and iNOS (mouse), respectively. The reported K_i value for the inhibition of iNOS ranges from 4-65 μM. L-NAME inhibits cGMP formation in endothelial cells with an IC₅₀ of 3.1 μM (in the presence of 30 μM arginine) and reverses the vasodilation effects of acetylcholine in rat aorta rings with an EC₅₀ of 0.54 μM.

Chemische Eigenschaften

Crystalline

Verwenden

Nitroarginine Methyl Ester Hydrochloride is used in the synthesis of N/CD13 inhibitors playing an important role in tumor invasion, metastatsis and angiogenesis. Also used in the preparation of spirocyclic lactam as a type II’ β-turn inducer.

Definition

ChEBI: A hydrochloride obtained by combining Ngamma-nitro-L-arginine methyl ester with one equivalent of hydrochloric acid.

Allgemeine Beschreibung

More soluble analog of arginine and a competitive, slowly reversible inhibitor of endothelial nitric oxide synthase (IC₅₀ = 500 nM). Causes a prolonged inhibition of acetylcholine-induced relaxation of rat aortic rings (IC₅₀ = 400 nM).

Biologische Aktivität

NO synthase inhibitor.

Methyl-N5-[imino(nitroamino)methyl]-L-ornithinmonohydrochlorid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Methyl-N5-[imino(nitroamino)methyl]-L-ornithinmonohydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29626	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21533	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29766	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	0531-68652808 18953170293	sales@sdzschem.com	China	2921	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19935	58
CONIER CHEM AND PHARMA LIMITED		sales@conier.com	China	49906	58
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32431	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-81139210 +86-17392587031	1059@dideu.com	China	9983	58
Finetech Industry Limited	+86-27-8746-5837 +86-18627785180	info@finetechnology-ind.com	China	9537	58
Wuhan Fortuna Chemical Co., Ltd	+86-27-59207850	info@fortunachem.com	China	5986	58

51298-62-5(Methyl-N5-[imino(nitroamino)methyl]-L-ornithinmonohydrochlorid)Verwandte Suche:

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• L-NG-Nitroarginine Methyl Ester (L-NAME)
• Nω-Nitro-L-arginine methyl ester hydrochloride (L-NAME)
• L-Arg(NO2)-Ome·HCl
• H-Aeg(NO2)-OMe.HCL
• (S)-Methyl 2-amino-5-(3-nitroguanidino)-pentanoate hydrochloride
• NG-nitro-L-Arg-OMe*HCl
• L-Ornithine, N5-[imino(nitroamino)methyl]-, methyl ester, hydrochloride (1:1)
• 2-(4-amino-5-oxohexyl)-1-nitroguanidine hydrochloride
• N5-NITRO-L-ARGININE METHYL ESTER DIHYDROCHLORIDE
• Nitro-L-arginineMethylEsterHCl
• NW-NITRO-L-ARGININEMETHYLESTERHYDROCHLORIDE
• H-Ala(NO2)-OMe hydrochloride
• NITROARGININEMETHYLESTERHYDROCHLORIDE
• H-L-Arg(NO2)-OMe*HCl
• H-Arg(NOZ)-OMe.HCl
• methyl N5-[imino(nitroamino)methyl]-L-ornithine monohydrochloride
• H-Ala(NO2)-OMeHCl
• H-Ala(No2)-Omecl
• ω-Nitro-L-arginine methyl·hydrochloric acid
• NG-Nitro-L-arginine-methyl ester hydrochloride,98%
• Nω-Nitro-L-arginine methyl ester hydrochloride ,98%
• Nω-Nitro-L-arginine methyl ester hydrochloride,L-NAME hydrochloride
• L-Ornithine, N5-[iMino(nitroaMino)Methyl]-, Methyl ester, Monohydrochloride
• H-Arg(NO2)-OMe·HCl N-ω-Nitro-L-arginine Methyl ester hydrochloride
• NG-Nitro-L-arginine-Methyl ester hydrochloride, 98% 5GR
• N(gamma)-nitro-L-arginine methyl ester hydrochloride
• Nω-Nitro-L-Arginine Methyl ester hydrochloride, 98%, a nonselective inhibitor of nitric oxide synthetases (NOS)
• NG-Nitro-L-arginine Methyl Ester, Hydrochloride - CAS 51298-62-5 - Calbiochem
• L-NAME hydrochloride (NG-Nitroarginine methyl ester hydrochloride)
• NG-Nitroarginine methyl ester hydrochloride
• methyl (2S)-2-amino-5-(N'-nitrocarbamimidamido)pentanoate hydrochloride
• H-Arg(NO2)-OMe¤HC
• L-NAME hydrochloride H-Arg(NO2)-OMe·HCl
• L-NAME HCL
• L-NAME HYDROCHLORIDE
• L-NG-NITROARGININE METHYL ESTER HCL
• L-NG-NITROARGININE METHYL ESTER HYDROCHLORIDE
• H-ARG(NO2)-OME HCL
• H-ARG(NO2)-OME HYDROCHLORIDE
• ARGININE(NO2)-OME HCL
• H-Arg(NO₂)-OMe·HCl
• N_ω-Nitro-L-arginine methyl ester hydrochloride
• S(+)-N5-[IMINO(NITROAMINO)METHYL]-L-ORNITHINE METHYL ESTER HYDROCHLORIDE
• N-OMEGA-NO2-L-ARG-OME, HCL
• N-OMEGA-NO2-L-ARG-OME, HYDROCHLORIDE
• N-OMEGA-NITRO-L-ARGININE METHYL ESTER HYDROCHLORIDE
• NITRO-L-ARGININE METHYL ESTER HYDROCHLORIDE
• NG-NO2-L-ARG-OME, HCL
• NG-NO2-L-ARG-OME, HYDROCHLORIDE
• NG-NITRO-L-ARGININE-METHYL ESTER HCL
• NG-NITRO-L-ARGININE METHYL ESTER HYDROCHLORIDE
• N(G)-NITRO-L-ARGININE METHYL ESTER HYDROCHLORIDE SALT
• N5-[IMINO(NITROAMINO)METHYL]-L-ORNITHINE, METHYL ESTER, MONOHYDROCHLORIDE
• Nω-Nitro-L-arginineMethylEsterHydrochloride>
• N'-Nitro-L-arginine-methyl ester hydrochloride USP/EP/BP
• Argatroban Impurity 75 HCl
• 4-Nitro-L-Arginine methyl ester.HCL
• Nomega-Nitro-L-arginine Methyl Ester Hydrochloride, ≥ 98.0%