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N'-Nitro-L-arginine-methyl ester hydrochloride

N'-Nitro-L-arginine-methyl ester hydrochloride structure

CAS No.: 51298-62-5

Chemical Name:: N'-Nitro-L-arginine-methyl ester hydrochloride

Synonyms: L-NAME;N-NITRO-L-ARGININE METHYL ESTER HYDROCHLORIDE;L-NAME HCL;H-Ala(NO2)-OMeHCl;H-Ala(No2)-Omecl;H-Arg(NO2)-OMe¤HC;H-Aeg(NO2)-OMe.HCL;L-Arg(NO2)-Ome·HCl;H-Arg(NOZ)-OMe.HCl;H-ARG(NO2)-OME HCL

CBNumber:: CB6350079

Molecular Formula:: C7H16ClN5O4

Molecular Weight:: 269.69

MDL Number:: MFCD00039052

MOL File:: 51298-62-5.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-27 17:00:41

Product description	Number	Pack Size	Price
Nω-Nitro-L-arginine methyl ester hydrochloride ≥98% (TLC), powder	N5751	1g	$59
NG-Nitro-L-arginine Methyl Ester, Hydrochloride - CAS 51298-62-5 - Calbiochem	483125-M	100mg	$75.4
Nomega-Nitro-L-arginine Methyl Ester Hydrochloride >98.0%(HPLC)(T)	N0661	5g	$104
Nomega-Nitro-L-arginine Methyl Ester Hydrochloride >98.0%(HPLC)(T)	N0661	25g	$277
L-NAME (hydrochloride) ≥98%	80210	1g	$20
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N'-Nitro-L-arginine-methyl ester hydrochloride Properties

Melting point	157-161 °C (dec.)
alpha	14.5 º (c=3, CH3OH)
refractive index	15 ° (C=3, MeOH)
RTECS	RM2982570
storage temp.	-20°C
solubility	H₂O: 50 mg/mL
form	powder
color	white to off-white
biological source	synthetic
Water Solubility	almost transparency
BRN	3744166
InChI	1S/C7H15N5O4.ClH/c1-16-6(13)5(8)3-2-4-10-7(9)11-12(14)15;/h5H,2-4,8H2,1H3,(H3,9,10,11);1H/t5-;/m0./s1
InChIKey	QBNXAGZYLSRPJK-JEDNCBNOSA-N
SMILES	Cl.COC(=O)[C@@H](N)CCCNC(=N)N[N+]([O-])=O
CAS DataBase Reference	51298-62-5(CAS DataBase Reference)
FDA UNII	TFX6A1PRZ1
UNSPSC Code	12352209
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319

Precautionary statements

P261-P305+P351+P338

PPE

Eyeshields, Gloves, type N95 (US)

Hazard Codes

Risk Statements

22-36/37/38

Safety Statements

22-24/25-36-26

WGK Germany

HS Code

29299090

Storage Class

11 - Combustible Solids

NFPA 704

	1
1		0

N'-Nitro-L-arginine-methyl ester hydrochloride price More Price(99)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	N5751	Nω-Nitro-L-arginine methyl ester hydrochloride ≥98% (TLC), powder	51298-62-5	1g	$59	2026-04-30	Buy
Sigma-Aldrich	483125-M	NG-Nitro-L-arginine Methyl Ester, Hydrochloride - CAS 51298-62-5 - Calbiochem	51298-62-5	100mg	$75.4	2026-04-30	Buy
TCI Chemical	N0661	Nomega-Nitro-L-arginine Methyl Ester Hydrochloride >98.0%(HPLC)(T)	51298-62-5	5g	$104	2026-04-30	Buy
TCI Chemical	N0661	Nomega-Nitro-L-arginine Methyl Ester Hydrochloride >98.0%(HPLC)(T)	51298-62-5	25g	$277	2026-04-30	Buy
Cayman Chemical	80210	L-NAME (hydrochloride) ≥98%	51298-62-5	1g	$20	2026-04-30	Buy

Product number	Packaging	Price	Buy
N5751	1g	$59	Buy
483125-M	100mg	$75.4	Buy
N0661	5g	$104	Buy
N0661	25g	$277	Buy
80210	1g	$20	Buy

N'-Nitro-L-arginine-methyl ester hydrochloride Chemical Properties,Uses,Production

Description

L-NAME requires hydrolysis of the methyl ester by cellular esterases to become a fully functional inhibitor (L-NNA). L-NNA exhibits some selectivity for inhibition of neuronal and endothelial isoforms. It exhibits K_i values of 15 nM, 39 nM, and 4.4 μM for nNOS (bovine), eNOS (human), and iNOS (mouse), respectively. The reported K_i value for the inhibition of iNOS ranges from 4-65 μM. L-NAME inhibits cGMP formation in endothelial cells with an IC₅₀ of 3.1 μM (in the presence of 30 μM arginine) and reverses the vasodilation effects of acetylcholine in rat aorta rings with an EC₅₀ of 0.54 μM.

Chemical Properties

Crystalline

Uses

Nitroarginine Methyl Ester Hydrochloride is used in the synthesis of N/CD13 inhibitors playing an important role in tumor invasion, metastatsis and angiogenesis. Also used in the preparation of spirocyclic lactam as a type II’ β-turn inducer.

Definition

ChEBI: A hydrochloride obtained by combining Ngamma-nitro-L-arginine methyl ester with one equivalent of hydrochloric acid.

General Description

More soluble analog of arginine and a competitive, slowly reversible inhibitor of endothelial nitric oxide synthase (IC₅₀ = 500 nM). Causes a prolonged inhibition of acetylcholine-induced relaxation of rat aortic rings (IC₅₀ = 400 nM).

Biological Activity

NO synthase inhibitor.

Biochem/physiol Actions

Primary TargeteNOS

storage

Room temperature

References

[1] C. K. BUCKNER. Analysis of Leukotriene Receptor Antagonists on Isolated Human Intralobar Airways[J]. Annals of the New York Academy of Sciences, 1988, 524 1: 181-186. DOI: 10.1111/j.1749-6632.1988.tb38540.x
[2] ERIC S. FURFINE. Selective inhibition of constitutive nitric oxide synthase by L-NG-nitroarginine[J]. Biochemistry Biochemistry, 1993, 32 33: 8512-8517. DOI: 10.1021/bi00084a017
[3] H M ABU-SOUD. Electron transfer in the nitric-oxide synthases. Characterization of L-arginine analogs that block heme iron reduction.[J]. The Journal of Biological Chemistry, 1994, 269 51: 32318-32326.
[4] D.D. REES. Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo[J]. British Journal of Pharmacology, 1990, 101 3: 746-752. DOI: 10.1111/j.1476-5381.1990.tb14151.x
[5] P.K. MOORE. l-NG-nitro arginine (l-NOARG), a novel, l-arginine-reversible inhibitor of endothelium-dependent vasodilatation in vitro[J]. British Journal of Pharmacology, 1990, 99 2: 408-412. DOI: 10.1111/j.1476-5381.1990.tb14717.x
[6] LINLIN LI. iNOS-derived nitric oxide promotes glycolysis by inducing pyruvate kinase M2 nuclear translocation in ovarian cancer.[J]. Oncotarget, 2017, 8 20: 33047-33063. DOI: 10.18632/oncotarget.16523
[7] SABRINA JARAZO DIETRICH. Inhibition of NOS-NO System Prevents Autoimmune Orchitis Development in Rats: Relevance of NO Released by Testicular Macrophages in Germ Cell Apoptosis and Testosterone Secretion.[J]. PLoS ONE, 2015: e0128709. DOI: 10.1371/journal.pone.0128709
[8] COURTNEY PREMER. Allogeneic Mesenchymal Stem Cells Restore Endothelial Function in Heart Failure by Stimulating Endothelial Progenitor Cells.[J]. EBioMedicine, 2015, 2 5: 467-475. DOI: 10.1016/j.ebiom.2015.03.020
[9] JEFF REESE . Regulation of the fetal mouse ductus arteriosus is dependent on interaction of nitric oxide and COX enzymes in the ductal wall[J]. Prostaglandins & other lipid mediators, 2009, 88 3: Pages 89-96. DOI: 10.1016/j.prostaglandins.2008.11.001

N'-Nitro-L-arginine-methyl ester hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

N'-Nitro-L-arginine-methyl ester hydrochloride Suppliers

Global( 410)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29626	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21533	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29766	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	0531-68652808 18953170293	sales@sdzschem.com	China	2921	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19935	58
CONIER CHEM AND PHARMA LIMITED		sales@conier.com	China	49906	58
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32431	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-81139210 +86-17392587031	1059@dideu.com	China	9983	58
Finetech Industry Limited	+86-27-8746-5837 +86-18627785180	info@finetechnology-ind.com	China	9537	58
Wuhan Fortuna Chemical Co., Ltd	+86-27-59207850	info@fortunachem.com	China	5986	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	58
BOC Sciences	58
CONIER CHEM AND PHARMA LIMITED	58
TargetMol Chemicals Inc.	58
Shaanxi Dideu Medichem Co. Ltd	58
Finetech Industry Limited	58
Wuhan Fortuna Chemical Co., Ltd	58

View Lastest Price from N'-Nitro-L-arginine-methyl ester hydrochloride manufacturers

Update time	Product	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-09	N'-Nitro-L-arginine-methyl ester hydrochloride 51298-62-5	1g	98%min	1000g	WUHAN FORTUNA CHEMICAL CO., LTD
2026-07-27	L-NAME hydrochloride 51298-62-5		99.75%	10g	TargetMol Chemicals Inc.
2026-06-30	N'-Nitro-L-arginine-methyl ester hydrochloride 51298-62-5	1kg	99%	10000KGS	Shaanxi Dideu New Materials Co. Ltd

N'-Nitro-L-arginine-methyl ester hydrochloride
51298-62-5
$0.00
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

L-NAME hydrochloride
51298-62-5
$0.00
99.75%
TargetMol Chemicals Inc.

N'-Nitro-L-arginine-methyl ester hydrochloride
51298-62-5
$0.00
99%
Shaanxi Dideu New Materials Co. Ltd

N'-Nitro-L-arginine-methyl ester hydrochloride Spectrum

N'-Nitro-L-arginine-methyl ester hydrochloride(51298-62-5)MS N'-Nitro-L-arginine-methyl ester hydrochloride(51298-62-5)¹HNMR

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L-NG-Nitroarginine Methyl Ester (L-NAME) Nω-Nitro-L-arginine methyl ester hydrochloride (L-NAME) L-Arg(NO2)-Ome·HCl H-Aeg(NO2)-OMe.HCL (S)-Methyl 2-amino-5-(3-nitroguanidino)-pentanoate hydrochloride NG-nitro-L-Arg-OMe*HCl L-Ornithine, N5-[imino(nitroamino)methyl]-, methyl ester, hydrochloride (1:1) 2-(4-amino-5-oxohexyl)-1-nitroguanidine hydrochloride N5-NITRO-L-ARGININE METHYL ESTER DIHYDROCHLORIDE Nitro-L-arginineMethylEsterHCl NW-NITRO-L-ARGININEMETHYLESTERHYDROCHLORIDE H-Ala(NO2)-OMe hydrochloride NITROARGININEMETHYLESTERHYDROCHLORIDE H-L-Arg(NO2)-OMe*HCl H-Arg(NOZ)-OMe.HCl methyl N5-[imino(nitroamino)methyl]-L-ornithine monohydrochloride H-Ala(NO2)-OMeHCl H-Ala(No2)-Omecl ω-Nitro-L-arginine methyl·hydrochloric acid NG-Nitro-L-arginine-methyl ester hydrochloride,98% Nω-Nitro-L-arginine methyl ester hydrochloride ,98% Nω-Nitro-L-arginine methyl ester hydrochloride,L-NAME hydrochloride L-Ornithine, N5-[iMino(nitroaMino)Methyl]-, Methyl ester, Monohydrochloride H-Arg(NO2)-OMe·HCl N-ω-Nitro-L-arginine Methyl ester hydrochloride NG-Nitro-L-arginine-Methyl ester hydrochloride, 98% 5GR N(gamma)-nitro-L-arginine methyl ester hydrochloride Nω-Nitro-L-Arginine Methyl ester hydrochloride, 98%, a nonselective inhibitor of nitric oxide synthetases (NOS) NG-Nitro-L-arginine Methyl Ester, Hydrochloride - CAS 51298-62-5 - Calbiochem L-NAME hydrochloride (NG-Nitroarginine methyl ester hydrochloride) NG-Nitroarginine methyl ester hydrochloride methyl (2S)-2-amino-5-(N'-nitrocarbamimidamido)pentanoate hydrochloride H-Arg(NO2)-OMe¤HC L-NAME hydrochloride H-Arg(NO2)-OMe·HCl L-NAME HCL L-NAME HYDROCHLORIDE L-NG-NITROARGININE METHYL ESTER HCL L-NG-NITROARGININE METHYL ESTER HYDROCHLORIDE H-ARG(NO2)-OME HCL H-ARG(NO2)-OME HYDROCHLORIDE ARGININE(NO2)-OME HCL H-Arg(NO₂)-OMe·HCl N_ω-Nitro-L-arginine methyl ester hydrochloride S(+)-N5-[IMINO(NITROAMINO)METHYL]-L-ORNITHINE METHYL ESTER HYDROCHLORIDE N-OMEGA-NO2-L-ARG-OME, HCL N-OMEGA-NO2-L-ARG-OME, HYDROCHLORIDE N-OMEGA-NITRO-L-ARGININE METHYL ESTER HYDROCHLORIDE NITRO-L-ARGININE METHYL ESTER HYDROCHLORIDE NG-NO2-L-ARG-OME, HCL NG-NO2-L-ARG-OME, HYDROCHLORIDE NG-NITRO-L-ARGININE-METHYL ESTER HCL NG-NITRO-L-ARGININE METHYL ESTER HYDROCHLORIDE N(G)-NITRO-L-ARGININE METHYL ESTER HYDROCHLORIDE SALT N5-[IMINO(NITROAMINO)METHYL]-L-ORNITHINE, METHYL ESTER, MONOHYDROCHLORIDE Nω-Nitro-L-arginineMethylEsterHydrochloride> N'-Nitro-L-arginine-methyl ester hydrochloride USP/EP/BP Argatroban Impurity 75 HCl 4-Nitro-L-Arginine methyl ester.HCL Nomega-Nitro-L-arginine Methyl Ester Hydrochloride, ≥ 98.0%