Amoxicillin trihydrate
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- CAS-Nr.
- 61336-70-7
- Englisch Name:
- Amoxicillin trihydrate
- Synonyma:
- AMOXYCILLIN TRIHYDRATE;AMOXICILIN TRIHYDRATE;AmoxiciL;AmoxicillineTrihydrate;AMOXICILLIN TRIHYDRATE IP;Amoxicillin trihydrate for performance verification CRS;Am 7;A-Gram;Amodex;Ardine
- CBNumber:
- CB6690306
- Summenformel:
- C16H21N3O6S
- Molgewicht:
- 383.42
- MOL-Datei:
- 61336-70-7.mol
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Amoxicillin trihydrate Eigenschaften
- Schmelzpunkt:
- >200°C (dec.)
- alpha
- D20 +246° (c = 0.1)
- Brechungsindex
- 302 ° (C=0.1, H2O)
- storage temp.
- Inert atmosphere,2-8°C
- Löslichkeit
- Slightly soluble in water, very slightly soluble in ethanol (96 per cent), practically insoluble in fatty oils. It dissolves in dilute acids and dilute solutions of alkali hydroxides.
- Aggregatzustand
- Solid
- Farbe
- White to Off-White
- Wasserlöslichkeit
- Soluble in water at 3.4mg/ml.
- Merck
- 14,577
- JECFA Number
- 85
- BRN
- 7507120
- Major Application
- clinical testing
- InChIKey
- AIPFZZHNBUVELL-KQLYYQCPNA-N
- SMILES
- C([C@H]1C(S[C@]2([H])[C@H](NC(=O)[C@@H](C3C=CC(O)=CC=3)N)C(=O)N12)(C)C)(=O)O.O |&1:1,4,6,10,r|
- CAS Datenbank
- 61336-70-7(CAS DataBase Reference)
- EPA chemische Informationen
- Amoxicillin trihydrate (61336-70-7)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
Xn,Xi |
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| R-Sätze: |
42/43 |
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| S-Sätze: |
36-36/37-22 |
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| WGK Germany |
2 |
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| RTECS-Nr. |
XH8300000 |
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| HS Code |
29411000 |
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| Speicherklasse |
11 - Combustible Solids |
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| Hazard Classifications |
Resp. Sens. 1
Skin Sens. 1 |
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| Toxizität |
LD50 ipr-rat: 2870 mg/kg KSRNAM 7,3040,73 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Achtung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H317 |
Kann allergische Hautreaktionen verursachen. |
Sensibilisierung der Haut |
Kategorie 1A |
Warnung |
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P261, P272, P280, P302+P352,P333+P313, P321, P363, P501 |
| H334 |
Kann bei Einatmen Allergie, asthmaartige Symptome oder Atembeschwerden verursachen. |
Sensibilisierung der Atemwege |
Kategorie 1 |
Achtung |
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P261, P285, P304+P341, P342+P311,P501 |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P272 |
Kontaminierte Arbeitskleidung nicht außerhalb des Arbeitsplatzes tragen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P284 |
Atemschutz tragen. |
| P302+P352 |
BEI BERÜHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckmäßig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P333+P313 |
Bei Hautreizung oder -ausschlag: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen. |
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Amoxicillin trihydrate Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R42/43:Sensibilisierung durch Einatmen und Hautkontakt möglich.
S-Sätze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S22:Staub nicht einatmen.
Beschreibung
Amoxicillin was synthesized by Beecham Research Laboratories in 1968. A hydroxyl group was introduced on the benzene ring of ampicillin. Amoxicillin shows about a twofold higher serum concentration than ampicillin when administered orally. It was shown by double-blind comparative studies with ampicillin that amoxicillin was as effective as ampicillin when administered at half the dose of ampicillin.
Chemische Eigenschaften
White to Off-White Solid
Verwenden
Amoxicillin trihydratesemi-synthetic antibiotic related to Penicillin which has antibacterial poperties. It is used for treatment of a variety of bacterial infections. It is used as a pharmaceutical product as a antibiotic agent, anti-infective drug raw materials.
Definition
ChEBI: A hydrate that is the trihydrate form of amoxicillin; a semisynthetic antibiotic, used either alone or in combination with potassium clavulanate (under the trade name Augmentin) for treatment of a variety of bacterial infections.
Kontakt-Allergie
Amoxicillin is both a topical and a systemic sensitizer.
Topical sensitization occurs in health care workers.
Systemic drug reactions are frequent, such as urticaria,
maculo-papular rashes, baboon syndrome, acute generalized
exanthematous pustulosis, or even toxic epidermal
necrosis. Cross-reactivity is common with
ampicillin, and can occur with other penicillins.
Sicherheitsprofil
Moderately toxic. An
experimental teratogen. Other experimental
reproductive effects. When heated to
decomposition it emits toxic fumes of SOx
and NOx.
Synthese
Amoxicillin trihydrate crystals can be obtained through a malic acid-assisted crystallization framework under optimized conditions (2.5 M malic acid, pH 5.5, 60 min, 1500 rpm), reaching 99.21% purity and 61.82% yield[1].
Amoxicillin trihydrate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Amoxicillin trihydrate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 679)Lieferanten
61336-70-7()Verwandte Suche:
- AmoxycillinTrihydrateBp98
- AMOXICILLINE 3-HYDRATE
- 6-(D-[-]-α-Amino-p-hydroxyphenylacetamido) penicillanic acid trihydrate
- 4-Thia-1-azabicyclo3.2.0heptane-2-carboxylic acid, 6-(2R)-amino(4-hydroxyphenyl)acetylamino-3,3-dimethyl-7-oxo-, trihydrate, (2S,5R,6R)-
- AMOXICILLINTRIHYDRATE,USP
- amoxicillin soluble powder70%
- 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-((amino(4-hydroxyphenyl)acetyl)amino)-3,3-dimethyl-7-oxo-, trihydrate (2S-(2alpha,5alpha,6beta(S*)))-
- A-Gram
- Am 7
- Amodex
- Amoksicillin
- Amoxicillin (200 mg)
- AMoxicillin Trihydrate CoMpacted / Powder
- Amoxicillin trihydrate for performance verification
- Amoxycilline Trihydrate Micronised
- AMOXICILLIN:3H2O
- Ardine
- HelvaMox
- Pasetocin
- PeniMox
- ZaMocillin
- AMoxicillin trihydrate API
- Amoxicillin Trihyelrate
- Amoxicillin trihyrate
- Amoxicillin (hydrate)
- (2S,5R,6R)-6-[[(2R)-2-Amino-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid trihydrate
- Amoxicillin tartrate soluhble powder
- Amoxyclillin Trihydrate
- Amoxicillin Trihydrate, CP
- Amoxicillin Trihydrate, 98%,HPLC
- 6-((amino(4-hydroxyphenyl)acetyl)amino)-3,3-dimethyl-7-oxo-,trihydrate,(2s-(2-alpha,5-alpha,6-beta4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylicaci
- acetyl)amino)-3,3-dimethyl-7-oxo-,trihydrate,(2s-(2-alpha,5-alpha,6-beta(s*)
- alpha-amino-p-hydroxybenzylpenicillintrihydrate
- brl2333trihydrate
- 6-[2-amino-2-(4-hydroxyphenyl)-acetyl]amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid trihydrate
- AMOXICILIN TRIHYDRATE
- AMOXICILLIN TRIHYDRATE
- AMOXICILLIN T TRIHYDRATE
- AMOXYCILLIN TRIHYDRATE
- D-(-)-ALPHA-AMINO-P-HYDROXYBENZYL PENICILLIN TRIHYDRATE
- AMOXICILLIN TRIHYDRATE VETRANAL, 250 MG
- AMOXICILLIN TRIHYDRATE EPA(CRM STANDARD)
- AMOXICILLIN TRIHYDRATE MM(CRM STANDARD)
- AmoxycillinTrihydrateAmoxycillinTrihydrateBp/Usp
- AMoxillat
- in Trihydrate
- Amoxicillin trihydrate for performance verification CRS
- Amoxicillin Trihydrate>
- Amoxicillin Trihydrate Standard
- Amoxipen trihydrate
- Moxaline trihydrate
- (2S,5R,6R)-6-[(2R)-2-amino-2-(4-hydroxyphenyl)ac etamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3. 2.0]heptane-2-carboxylic acid trihydrate
- Amoxicillin trihydrate USP/EP/BP
- AMOXICILLIN TRIHYDRADE WITH CLAVULANATE POTASSIUM 4:1
- (2S,5R,6R)-6-((R)-2-Amino-2-(4-hydroxyphenyl)acetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid trihydrate
- Amoxicillin Trihydrate (Amoxycillin)
- Amoxicillin trihydrate (A0800000)Q: What is
Amoxicillin trihydrate (A0800000) Q: What is the CAS Number of
Amoxicillin trihydrate (A0800000)
- Amoxicillin trihydrate for performance verification (Y0001521)Q: What is
Amoxicillin trihydrate for performance verification (Y0001521) Q: What is the CAS Number of
Amoxicillin trihydrate for performance verification (Y0001521)
