5-Ethyldihydro-5-(1-methylbutyl)-2-thioxo-4,6(1H,5H)-pyrimidindion,Mononatrium-Salz
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- CAS-Nr.
- 71-73-8
- Bezeichnung:
- 5-Ethyldihydro-5-(1-methylbutyl)-2-thioxo-4,6(1H,5H)-pyrimidindion,Mononatrium-Salz
- Englisch Name:
- Thiopental Sodium
- Synonyma:
- ravonal;farmotal;trapanal;hypnostan;leopental;thionembutal;Thiopentemal;trapanalsodium;intravalsodium;nesdonalsodium
- CBNumber:
- CB7106914
- Summenformel:
- C11H17N2NaO2S
- Molgewicht:
- 264.32
- MOL-Datei:
- 71-73-8.mol
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5-Ethyldihydro-5-(1-methylbutyl)-2-thioxo-4,6(1H,5H)-pyrimidindion,Mononatrium-Salz Eigenschaften
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
T |
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| R-Sätze: |
25 |
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| S-Sätze: |
36-45 |
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| RIDADR |
UN 2811 6.1/PG 3 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
CQ6475000 |
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| HazardClass |
6.1(b) |
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| PackingGroup |
III |
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| Toxizität |
LD50 in mice (mg/kg): 149 i.p.; 78 i.v. (Christensen, Lee) |
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| Bildanzeige (GHS) |
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| Alarmwort |
Achtung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H301 |
Giftig bei Verschlucken. |
Akute Toxizität oral |
Kategorie 3 |
Achtung |
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P264, P270, P301+P310, P321, P330,P405, P501 |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P301+P310 |
BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P321 |
Besondere Behandlung |
| P330 |
Mund ausspülen. |
| P405 |
Unter Verschluss aufbewahren. |
| P501 |
Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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5-Ethyldihydro-5-(1-methylbutyl)-2-thioxo-4,6(1H,5H)-pyrimidindion,Mononatrium-Salz Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R25:Giftig beim Verschlucken.
S-Sätze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Chemische Eigenschaften
Thiopental Sodium is a Yellowish-white powder that is hygroscopic and readily soluble in water; its aqueous solution (1:40) is strongly alkaline (pH 9.5–11.2). It is soluble in alcohol and has a garlic-like odour. It is unstable; its aqueous solution undergoes hydrolysis when left standing. The dry powder is sealed in ampoules, and the solution is prepared immediately prior to use.
Verwenden
Pentothal (Abbott).
Definition
A rapidly acting barbiturate administered
intravenously for general anesthesia and hypnosis.
Commonly known as “truth serum.”
Hazard
May cause respiratory failure; use onlywith
physician in attendance.
Pharmakokinetik
Thiopental is highly bound to albumin, and free drug availability is increased
in hypoproteinaemia. Protein binding is decreased by alkalaemia,
hyperventilation and some drugs that occupy the same albumin binding
sites, thereby increasing unbound thiopental concentrations. Metabolism
occurs predominantly in the liver, and the metabolites are excreted by the
kidneys. Only a small proportion is excreted unchanged in the urine. The
terminal elimination half-life is approximately 11.5h (longer in the elderly).
Elimination after an infusion is a zero-order process with 10%–15% of the
remaining drug metabolised each hour. Up to 30% of the original dose may
remain in the body at 24h, and a hangover effect is common. Accumulation
may result if further doses of thiopental are administered within 1–2 days.
Sicherheitsprofil
Poison by ingestion, intraperitoneal, rectal, subcutaneous, and intravenous routes. Human systemic effects by intraarterial route: acute arterial occlusion; by rectal route: respiratory depression, body temperature decrease, general anesthetic. An experimental teratogen. Experimental reproductive effects. An intravenous anesthetic. When heated to decomposition it emits toxic fumes of NO, and Na2O. See also PENTOTHAL and BARBITURATES
5-Ethyldihydro-5-(1-methylbutyl)-2-thioxo-4,6(1H,5H)-pyrimidindion,Mononatrium-Salz Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
5-Ethyldihydro-5-(1-methylbutyl)-2-thioxo-4,6(1H,5H)-pyrimidindion,Mononatrium-Salz Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 55)Lieferanten
71-73-8(5-Ethyldihydro-5-(1-methylbutyl)-2-thioxo-4,6(1H,5H)-pyrimidindion,Mononatrium-Salz)Verwandte Suche:
- 5-ethyl-5-(1-methylbutyl)-2-thiobarbituricacidmonosodium
- 5-ethyl-5-(1-methylbutyl)-2-thio-barbituricacisodiumsalt
- 6(1h,5h)-pyrimidinedione,5-ethyldihydro-5-(1-methylbutyl)-2-thioxo-monos
- 6(1h,5h)-pyrimidinedione,5-ethyldihydro-5-(1-methylbutyl)-2-thioxo-monosod
- farmotal
- tiopentalsodium
- trapanal
- trapanalsodium
- PENTOTHAL SODIUM-POTASSIUM SALT
- THIOPENTAL SODIUM
- THIOPENTAL SODIUM SALT
- (+/-)-THIOPENTAL SODIUM SALT/SODIUM CARBONATE
- (+/-)-THIOPENTAL SODIUM SALT-SODIUM CARBONATE MIXTURE
- 5-ETHYL-5-(1-METHYLBUTYL)-2-THIOBARBITURIC ACID SODIUM-POTASSIUM SALT
- 5-ETHYL-5-[1-METHYLBUTYL]-2-THIOBARBITURIC ACID SODIUM SALT/SODIUM CARBONATE
- (+,-)-THIOPENTAL SODIUM/SODIUM*CARBONATE --DEA SCHED
- THIOPENTAL SODIUM/SODIUM CARBONATE MIXTU RE >96% INTRAVENOUS AN
- 5-Ethyl-5-[1-methylbutyl]-2-thiobarbituric acid, sodium salt
- Thiopentone, sodium salt
- 4,6(1H,5H)-Pyrimidinedione, 5-ethyldihydro-5-(1-methylbutyl)-2-thioxo-, monosodium salt
- 4,6(1H,5H)-Pyrimidinedione, 5-ethyldihydro-5-(1-methylbutyl)-2-thioxo-, monosodium salt (9CI)
- Barbituric acid, 5-ethyl-5-(1-methylbutyl)-2-thio-, sodium deriv. (7CI)
- Barbituric acid, 5-ethyl-5-(1-methylbutyl)-2-thio-, sodium salt (8CI)
- Intra-Vital Sodium
- hypnostan
- intravalsodium
- leopental
- monosodium5-ethyl-5-(1-methylbutyl)thiobarbiturate
- nesdonalsodium
- penthiobarbitalsodium
- pentothalsodium
- ravonal
- sodium5-ethyl-5-(1-methylbutyl)-2-thiobarbiturate
- sodiumpenthiobarbital
- sodiumpentothal
- sodiumpentothiobarbital
- sodiumthiopental
- sodiumthiopentobarbital
- sodiumthiopentone
- solublethiopentone
- thiomebumalsodium
- thionembutal
- thiopentonesodium
- thiothalsodium
- thipentalsodium
- (+/-)-Thiopental SodiuM Salt-SodiuM Carbonate Mixture (CIII)
- 4,6(1H,5H)-PyriMidinedione,5-ethyldihydro-5-(1-Methylbutyl)-2-thioxo-, sodiuM salt (1:1)
- Thiopental sodium(for injection)
- RS-Thiopental sodium
- Sodium 5-ethyl-5-(a-methylbutyl)-2-thiobarbiturate
- Thionembutal sodium
- Thiopentobarbitone sodium
- Thiopentemal
- 5-Ethyl-5-(1-methylbutyl)-2-thiobarbutyrate sodium
- 5-Ethyl-5-(1-methylbutyl)-2-thiobarbituric acid, Pentothal
- 5-Ethyldihydro-5-(1-methylbutyl)-2-thioxo-4,6(1H,5H)-pyrimidinedione monosodium salt
- Sodium Carbpnate
- 5-Ethyldihydro-5-(1-methylbutyl)-2-thioxo-4,6(1H,5H)-pyrimidinedione sodium salt
