Thiopental Sodium
- CAS No.
- 71-73-8
- Chemical Name:
- Thiopental Sodium
- Synonyms
- ravonal;farmotal;trapanal;hypnostan;leopental;thionembutal;Thiopentemal;trapanalsodium;intravalsodium;nesdonalsodium
- CBNumber:
- CB7106914
- Molecular Formula:
- C11H17N2NaO2S
- Molecular Weight:
- 264.32
- MDL Number:
- MFCD00072013
- MOL File:
- 71-73-8.mol
- MSDS File:
- SDS
| solubility | H2O: >10 mg/mL |
|---|---|
| color | Yellowish hygroscopic powder |
| FDA UNII | 49Y44QZL70 |
| EPA Substance Registry System | Thiopental sodium (71-73-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P264-P270-P301+P310-P321-P330-P405-P501 |
| Hazard Codes | T |
| Risk Statements | 25 |
| Safety Statements | 36-45 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | CQ6475000 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| Toxicity | LD50 in mice (mg/kg): 149 i.p.; 78 i.v. (Christensen, Lee) |
Thiopental Sodium Chemical Properties,Uses,Production
Chemical Properties
Thiopental Sodium is a Yellowish-white powder that is hygroscopic and readily soluble in water; its aqueous solution (1:40) is strongly alkaline (pH 9.5–11.2). It is soluble in alcohol and has a garlic-like odour. It is unstable; its aqueous solution undergoes hydrolysis when left standing. The dry powder is sealed in ampoules, and the solution is prepared immediately prior to use.
History
Sodium thiopental was first synthesised in the early 1930s by Ernest H. Volwiler and Donalee L. Tabern at Abbott Laboratories. Owing to its rapid onset of action, Ralph M. Waters first administered sodium thiopental for human anaesthesia on 8 March 1934.
Uses
Pentothal (Abbott).
Definition
A rapidly acting barbiturate administered intravenously for general anesthesia and hypnosis. Commonly known as “truth serum.”
brand name
Thiopental is BAN.
General Description
Thiopental sodium is an organic sodium salt having thiopental(1) as the counter-ion. It has a role as an intravenous anaesthetic. It contains a thiopental(1-).
Hazard
May cause respiratory failure; use onlywith physician in attendance.
Pharmacokinetics
Thiopental is highly bound to albumin, and free drug availability is increased in hypoproteinaemia. Protein binding is decreased by alkalaemia, hyperventilation and some drugs that occupy the same albumin binding sites, thereby increasing unbound thiopental concentrations. Metabolism occurs predominantly in the liver, and the metabolites are excreted by the kidneys. Only a small proportion is excreted unchanged in the urine. The terminal elimination half-life is approximately 11.5h (longer in the elderly). Elimination after an infusion is a zero-order process with 10%–15% of the remaining drug metabolised each hour. Up to 30% of the original dose may remain in the body at 24h, and a hangover effect is common. Accumulation may result if further doses of thiopental are administered within 1–2 days.
Clinical Use
Thiopental sodium is a short-acting intravenous anesthetic used for brief surgical procedures and induction of anesthesia. It is a potent,rapidly effective hypnotic. Sleep ensues within 30 – 60 s. A disadvantage is the lengthy hangover. In the United States and Great Britain it is the most widely used injection anesthetic. Abuse can lead to addiction.
Safety Profile
Poison by ingestion, intraperitoneal, rectal, subcutaneous, and intravenous routes. Human systemic effects by intraarterial route: acute arterial occlusion; by rectal route: respiratory depression, body temperature decrease, general anesthetic. An experimental teratogen. Experimental reproductive effects. An intravenous anesthetic. When heated to decomposition it emits toxic fumes of NO, and Na2O. See also PENTOTHAL and BARBITURATES
Veterinary Drugs and Treatments
Because of its rapid action and short duration, in young, healthy animals, thiopental is excellent induction agent (rapid IV bolus) for general anesthesia with other anesthetics or as the sole anesthetic agent for very short procedures. In sick or debilitated animals, thiopental may be used in a more cautious manner (IV, slowly to effect).
Thiopental Sodium Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| skychemical Co.Ltd | 021-20958197 20965099 | sales@skychemical.com | China | 1182 | 57 |
| Spectrum Chemical Manufacturing Corp. | 021-021-021-67601398-809-809-809 15221380277 | marketing_china@spectrumchemical.com | China | 9643 | 60 |
| Chengdu Ai Keda Chemical Technology Co., Ltd. | 4008-755-333 18080918076 | 800078821@qq.com | China | 9706 | 55 |
| Beijing HuaMeiHuLiBiological Chemical | 010-56205725 | waley188@sohu.com | China | 12323 | 58 |
| Clearsynth Labs Limited | +91-22-26355700 | info@clearsynth.com | India | 9656 | 58 |
| Nanjing Sunlida Biological Technology Co., Ltd. | 025-57798810 18652991625 | sales@sunlidabio.com | China | 3223 | 55 |
| Chengdu RunZeBenTu Chemical Co., Ltd | 13096311329 028-88469284 616445927 | 616445927@qq.com | China | 2870 | 50 |
| Chizhou Kailong Import and Export Trade Co., Ltd. | xg01_gj@163.com | China | 9413 | 50 | |
| Conier Chem & Pharma Limited | 13368167990 | sales@conier.com | China | 187 | 58 |
| Shaanxi Jiandu Pharmaceutical Chemical Co. Ltd. | 029-88380327 17691182729 | 1053@dideu.com | China | 2001 | 58 |
Related articles
- Pharmacology of Thiopental sodium
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- Feb 24,2022
View Lastest Price from Thiopental Sodium manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-12 | 4,6(1H,5H)-Pyrimidinedione,5-ethyldihydro-5-(1-methylbutyl)-2-thioxo-, sodium salt (1:1)
71-73-8
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
 |
2026-08-20 | Thiopental Sodium USP/EP/BP
71-73-8
|
$1.10 | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2026-06-30 | Thiopental Sodium
71-73-8
|
1KG | 98 | 10000KGS | Shaanxi Dideu New Materials Co. Ltd |
-
- 4,6(1H,5H)-Pyrimidinedione,5-ethyldihydro-5-(1-methylbutyl)-2-thioxo-, sodium salt (1:1)
71-73-8
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- Thiopental Sodium USP/EP/BP
71-73-8
- $1.10
- 99.9%
- Dideu Industries Group Limited
-
- Thiopental Sodium
71-73-8
- 98
- Shaanxi Dideu New Materials Co. Ltd
