Levonorgestrel
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- CAS-Nr.
- 797-63-7
- Bezeichnung:
- Levonorgestrel
- Englisch Name:
- Levonorgestrel
- Synonyma:
- L-NORGESTREL;levonova;Levonorgestre;Levonorgestrel for system suitability 1 CRS;wy-5104;postinor;Microlut;Microval;norplant2;Levonelle
- CBNumber:
- CB7125746
- Summenformel:
- C21H28O2
- Molgewicht:
- 312.45
- MOL-Datei:
- 797-63-7.mol
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Levonorgestrel Eigenschaften
- Schmelzpunkt:
- 206°C
- alpha
- D20 -32.4° (c = 0.496 in CHCl3)
- Siedepunkt:
- 392.36°C (rough estimate)
- Dichte
- 1.0697 (rough estimate)
- Brechungsindex
- 1.4900 (estimate)
- storage temp.
- Sealed in dry,2-8°C
- Löslichkeit
- Practically insoluble in water, sparingly soluble in methylene chloride, slightly soluble in ethanol (96 per cent).
- pka
- 13.09±0.40(Predicted)
- Aggregatzustand
- Solid
- Farbe
- Crystals from MeOH/CHCl3
- Optische Rotation
- [α]/D -28 to -36° (C= 1.0g/100 ml in CDCl3)
- Wasserlöslichkeit
- 10mg/L(temperature not stated)
- Merck
- 13,6736
- Henry's Law Constant
- 1.3×104 mol/(m3Pa) at 25℃, HSDB (2015)
- BCS Class
- 1
- InChI
- InChI=1/C21H28O2/c1-3-20-11-9-17-16-8-6-15(22)13-14(16)5-7-18(17)19(20)10-12-21(20,23)4-2/h2,13,16-19,23H,3,5-12H2,1H3/t16-,17+,18+,19-,20-,21-/s3
- InChIKey
- WWYNJERNGUHSAO-HABXDNTMNA-N
- SMILES
- C([C@]12CC[C@]3([H])[C@@]4([H])CCC(=O)C=C4CC[C@@]3([H])[C@]1([H])CC[C@@]2(O)C#C)C |&1:1,4,6,16,18,22,r|
- CAS Datenbank
- 797-63-7(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
Xn,T |
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| R-Sätze: |
20/21/22-40-60 |
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| S-Sätze: |
22-36 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
JF8225000 |
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| HS Code |
2937230000 |
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| Speicherklasse |
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects |
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| Hazard Classifications |
Carc. 2
Lact.
Repr. 1A |
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| Giftige Stoffe Daten |
797-63-7(Hazardous Substances Data) |
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| Bildanzeige (GHS) |
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| Alarmwort |
Achtung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H351 |
Kann vermutlich Krebs verursachen. |
Karzinogenität |
Kategorie 2 |
Warnung |
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P201, P202, P281, P308+P313, P405,P501 |
| H362 |
Kann Säuglinge über die Muttermilch schädigen. |
Reproductive toxicity, effects on or via lactation |
Additional category |
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P201, P260, P263, P264, P270,P308+P313 |
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| Sicherheit |
| P202 |
Vor Gebrauch alle Sicherheitshinweise lesen und verstehen. |
| P260 |
Dampf/Aerosol/Nebel nicht einatmen. |
| P263 |
Kontakt während der Schwangerschaft /und der Stillzeit vermeiden. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P308+P313 |
BEI Exposition oder falls betroffen: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen. |
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Levonorgestrel Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R40:Verdacht auf krebserzeugende Wirkung.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Levonorgestrel exhibits some androgenic activity but no glucocortic oid or antimineraloc orticoid action. Levonorgestrel can be administered orally, transdermally (combined with estradiol and formulated as a 7-day patch), and for prolonged, continuous use, via an intrauterine device (IUD). The oral bioavailability of levonorgestrel is approximately 95%. From a protein binding pers pective, 48% of an oral dose is bound to SHBG, and 50% is bound to albumin. Levonorgestrel under goes metabolic reduction of its ketone and is hydroxylated.
Chemische Eigenschaften
White Solid
Definition
A synthetic steroid hormone used
as an ingredient of oral contraceptives. Approved
by FDA.
Sicherheitsprofil
Human reproductive effects byingestion: menstrual cycle changes, fertility index.Questionable carcinogen with experimental neoplastigenicdata. When heated to decomposition it emits acrid smokeand irritating fumes.
Levonorgestrel Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Levonorgestrel Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 461)Lieferanten
797-63-7(Levonorgestrel)Verwandte Suche:
- 13-ethyl-17-alpha-ethynyl-17-beta-hydroxy-4-gonen-3-one
- 13-ethyl-17-alpha-ethynylgon-4-en-17-beta-ol-3-one
- 13-ethyl-17-hydroxy-19-dinor-17-alpha-pregn-4-en-20-yn-3-on(+)-1
- 17-alpha-ethinyl-13-beta-ethyl-17-beta-hydroxy-4-estren-3-one
- microluton
- norplant2
- norplantii
- postinor
- wy-5104
- L-NORGESTREL
- D(minus)-norgestrel
- Norgestrel (L-)
- 13β-ethyl-17α-ethynyl-17β-hydroxygon-4-en-3-one
- LEVONORGESTEREL,USP
- D(-)-13beta-Ethyl-17alpha-ethynyl-17beta-hydroxygon-4-en-3-one
- Levonorgestrel
- (8S,9S,13S,14S,17S)-17-ethynyl-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3,17-diol
- (17α)-13-Ethyl-17-hydroxy-18,19-dinorpregn-4-en-yn-3-one
- 17-beta-hydroxy-18-methyl-19-nor-17-alpha-pregn-4-en-20-yn-3-one
- 17-ethynyl-18-methyl-19-nortestosteron
- 17-ethynyl-18-methyl-19-nortestosterone
- 18-methyl-17-alpha-ethynyl-19-nortestosterone
- 18-methylnorethindrone
- follistrel
- levonova
- LEVONORGESTREL (D-(-)-NORGESTREL)
- Dexnorgestrel
- Levonelle
- Microlut
- Microval
- Norgeston
- 17-Beta-Hydroxy-18-Me
- (8R,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-17-hydroxy-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one
- Levonorgestrel (200 mg)
- Levonorgestrel(Levonelle)
- 17-Ethynyl-18-Methyl-
- (-)-Levonorgestrel
(-)-17alpha-Ethynyl-18-methyl-19-nortestosterone
(-)-18,19-Dinor-13beta-ethyl-17beta-hydroxy-4-pregnen-20-yn-3-one
- Levinirgestrel
- Gestrinone Impurity 5
- 13-ethyl-17-hydroxy-, (17α)-18,19-Dinorpregn-4-en-20-yn-3-one
- Levonorgestrel for system suitability 2
- Levonorgestrel (125 mg)
- D-(-)-norgestrel solution,100ppm
- D-(-)-Norgestrel (Levonorgestrel)
- Levonorgestrel(797-63-7)
- [18,19-Dinorpregn-4-en-20-yn-3-one-13-ethyl-17-hydroxy-,(17.α.)-(-)-]
- Levonorgestrel for system suitability 1 CRS
- (-)-Norgestrel>
- Levonorgestrel for system suitability 2 CRS
- 97.0%(GC&
- Levonorgestrel CRS
- 18,19-Dinorpregn-4-en-20-yn-3-one, 13-ethyl-17-hydroxy-, (17α)-
- (8R,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-17-hydroxy-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one
- (-)-17alpha-Ethynyl-18-methyl-19-nortestosterone
- (-)-18,19-Dinor-13beta-ethyl-17beta-hydroxy-4-pregnen-20-yn-3-one
- (-)-Levonorgestrel
- Levonorgestrel USP/EP/BP
- Levonorgestrel for system suitability 1 (Y0001431)
