9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-dien-3,20-dion

9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione Struktur

981-34-0

CAS-Nr.: 981-34-0

Bezeichnung:: 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-dien-3,20-dion

Englisch Name:: 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione

Synonyma:: DB11;16-BETA METHYL EPOXIDE;9beta,11beta-epoxy-17alpha,21-dihydroxy-16beta-methylene-pregna-1,4-diene-3,20-dione;(9β,11β,16β)-;Einecs 213-563-4;16β Methyl Epoxide;9beta,11beta-Epoxy-1;11beta-Epoxy-17alpha;Betamethasone epoxide;16-beta Methyl Epoxid

CBNumber:: CB72129663

Summenformel:: C22H28O5

Molgewicht:: 372.45

MOL-Datei:: 981-34-0.mol

Request For Quotation

Eigenschaften Sicherheit Verwendungswort Produktionsfirma 239

9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-dien-3,20-dion Eigenschaften

Schmelzpunkt:: 210-220 ºC

Siedepunkt:: 564.9±50.0 °C(Predicted)

Dichte: 1.32±0.1 g/cm3(Predicted)

Dampfdruck: 0-357.304Pa at 25℃

storage temp.: Refrigerator

Löslichkeit: Chloroform (Slightly, Heated), Dioxane (Slightly, Heated), DMSO (Slightly, Heated)

Aggregatzustand: Solid

pka: 12.56±0.70(Predicted)

Farbe: White to Light Beige

Major Application: pharmaceutical small molecule

InChIKey: GBDXNHBVYAMODG-OBDZOPJXNA-N

SMILES: C[C@]12C=CC(=O)C=C1CC[C@@]1([H])[C@]3([H])C[C@H](C)[C@](O)(C(=O)CO)[C@@]3(C)C[C@@H]3O[C@]213 |&1:1,10,12,15,17,23,26,28,r|

Sicherheit

9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-dien-3,20-dion Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione (Betamethasone EP Impurity E) is a metabolite of Mometasone Furoate (M490000) which is a tropical corticosteroid used as an anti-inflammatory. Low solubility in most solvent. 9,11β-epoxysteroid compounds can be prepared by 9-position fluorination to obtain dexamethasone. By modifying its 3-bit, 6-bit, 16-bit, and 21-bit, a series of drugs can be prepared.

Chemische Eigenschaften

Off-White Solid

synthetische

Add sodium sulfite and sodium hydroxide to water, stir to dissolve, and then add methanol. The raw material was added for hydrolysis reaction. After the reaction for 3h, glacial acetic acid was added to adjust the pH=6~8. The water was added to the solution and crystallize at 0 ℃. Finally, 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione was obtained after purification.

9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione

9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-dien-3,20-dion Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-dien-3,20-dion Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 239)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21533	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29766	58
Xiamen AmoyChem Co., Ltd	+86-86-5926051114	sales@amoychem.com	China	6339	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19935	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413	contact@trustwe.com	China	5742	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17339	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +86-189 4982 3763	sales@tnjchem.com	China	34526	58
AFINE CHEMICALS LIMITED	+86-571-85134551 +86-18958018566	info@afinechem.com	China	15051	58
Finetech Industry Limited	+86-27-8746-5837 +86-18627785180	info@finetechnology-ind.com	China	9539	58
changzhou huayang technology co., ltd	+8615250961469	2571773637@qq.com	China	9628	58

981-34-0(9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-dien-3,20-dion)Verwandte Suche:

9β,11β-Epoxy-17,21-dihydroxy-16α-methylpregna-1,4-dien-3,20-dion Ethylenoxid 9-Fluor-11β,17,21-trihydroxy-16β-methylpregna-1,4-dien-3,20-dion-17-valerat Propan-1,2-diol Estra-1,3,5(10)-trien-3,17α-diol Pregna-1,4-dien-3,20-dion, 9-Fluor-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, Dinatriumsalz, (11β,16β)- Phenolic epoxy resin Basic Violet 1 9-Fluor-11β,17,21-trihydroxy-16β-methylpregna-1,4-dien-3,20-dion-21-acetat Methyl-4-hydroxybenzoat Kresoxim-methyl BETAMETHASONE DIPROPIONATE MM(CRM STANDARD) Methylacrylat Betamethason Diphenylmethan-4,4'-diisocyanat Methylenblau (C.I. 52015) Acetonitril Poly(ethylene glycol)

(9β)-9,11β-Epoxy-16β-methyl-17,21-dihydroxypregna-1,4-diene-3,20-dione
9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione
Einecs 213-563-4
Betamethasone 9,11-Epoxide
(9β,11β,16β)-
9beta,11beta-Epoxy-1
DB11(16B-Methyl Epoide)
DB11(16β-Methyl Epoide)
(4aS,4bS,5aS,6aS,7R,8S,9aS,9bS)-7-Hydroxy-7-(2-hydroxyacetyl)-4a,6a,8-triMethyl-5a,6,6a,7,8,9,9a,9b,10,11-decahydrocyclopenta[1,2]phenanthro[4,4a-b]oxiren-2(4aH)-one
Betamethasone epoxide
(4aS,4bS,5aS,6aS,7R,9aS,9bS)-7-Hydroxy-7-(2-hydroxyacetyl)-4a,6a-Dimethyl-8-methylene-5a,6,6a,7,8,9,9a,9b,10,11-decahydrocyclopenta[1,2]phenanthro[4,4a-b]oxiren-2(4aH)-one
Pregna-1,4-diene-3,20-dione,9
17α,21-dihydroxy-9β,11β-epoxy-16β-methylpregna-1,4-diene-3,20-dione
Beclomethasone EP Impurity R
Betamethasone Impurity 5（Betamethasone EP Impurity E）
Beclometasone Dipropionate?EP Impurity R
16-beta Methyl Epoxid
9,11beta-Epoxy-17,21-dihydroxy-16be
9Beta,11beta-Epoxy-17alpha,21-dihydroxy-16beta-methylene-pregna-1,4-diene-3,20-dione[DB11]
Pregna-1,4-diene-3,20-dione, 9,11-epoxy-17,21-dihydroxy-16-methyl-, (9β,11β,16β)-
Beclomethasone Impurity 6
Beta,11beta-Epoxy-17alpha,21-dihydroxy-16beta-methylene-pregna-1,4-diene-3,20-dione
Beclomethasone propionate EP impurity R
Beclomethasone Impurity 15(Beclometasone Dipropionate EP Impurity R)
9-beta,11-beta-epoxy-17-alpha,21-dihydroxy-16-beta-methylene...
DB11(16β-Methyl Epoxide)
11beta-Epoxy-17alpha
9,11β-Epoxy-17,21-dihydroxy-16β-methyl-9β-pregna-1,4-diene-3,20-dione
Beclomethasone dipropionate EP Impurity R
9-β,11-β-epoxy-17-α,21-dihydroxy-16-beta-methylenepregna-1,4-diene-3,20-dione
Beclometasone Propionate EP Impurity R
Beclometasone Dipropionate Impurity R
Betamethasone Impurity E
Beclometasone Propionate EP Impurity R（Betamethasone EP Impurity E）
Betamethasone 9,11-Epoxide (Beclomethasone Dipropionate EP Impurity R)
Beclomethasone Dipropionate EP Impurity R (Betamethasone 9,11-Epoxide)
Betamethasone epoxy hydrolysate
9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregnα-1,4-diene-3,20-dione
9beta,11beta-Epoxy-17alpha,21-dihydroxy-16beta-met
93.113-Epoxy-17a,21-dihydroxy-16p -methylenepregna-1.4-diene-3.20-dione(DB11)
(9β,11β,16β)-9,11-Epoxy-17,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione
Betamethasone epoxide hydrolase
Beclometasone Dipropionate EP Impurity R (Betamethasone 9,11-Epoxide)
Beclometasone Impurity R
9,11beta-Epoxy-17,21-dihydroxy-16beta-methyl-9beta-pregna-1,4-diene-3,20-dione
Betamethasone Epoxide Hydrolyzate
Beclomethasone Propionate intermediate
DB Xl - 9beta,11beta-Epoxy-17alpha,21-dihydroxy-16beta-methylene-pregna-1,4-diene-3,20-dione
16β Methyl Epoxide
9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione
Betamethasone 9,11-Epoxide（DB11）
9beta,11beta-Epoxy-17alpha
Beclometasone (Beclomethasone) Dipropionate EP Impurity R (Betamethasone 9,11-Epoxide)
16-BETA METHYL EPOXIDE
9beta,11beta-epoxy-17alpha,21-dihydroxy-16beta-methylene-pregna-1,4-diene-3,20-dione
DB11
Beclometasone dipropionate impurity 11
9b,11b-Epoxy-17,21-dihydroxy-16b-methylpregna-1,4-diene-3,20-dione