Beclometason
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- CAS-Nr.
- 4419-39-0
- Bezeichnung:
- Beclometason
- Englisch Name:
- BECLOMETHASONE
- Synonyma:
- Beclometasone;BecL;Becolvent;omethasone;BECLOMETHASONE;Chloro methimazole;BecloMethasone Solution;Beclomethasone - 98% min;Beclomethasone - 95% min;BECLOMETHASONE USP/EP/BP
- CBNumber:
- CB7694093
- Summenformel:
- C22H29ClO5
- Molgewicht:
- 408.92
- MOL-Datei:
- 4419-39-0.mol
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Beclometason Eigenschaften
- Schmelzpunkt:
- 217- 222°C (dec.)
- Siedepunkt:
- 600.2±55.0 °C(Predicted)
- Dichte
- 1.35±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- Löslichkeit
- Dioxane (Sparingly, Sonicated), DMSO (Sparingly), Ethyl Acetate (Slightly), Methane
- Aggregatzustand
- Solid
- pka
- 12.17±0.70(Predicted)
- Farbe
- White to Pale Beige
- Merck
- 13,1020
- Stabilität:
- Hygroscopic
- InChIKey
- NBMKJKDGKREAPL-WOOYFSPWSA-N
- SMILES
- [H][C@]12C[C@@H](C)[C@@](O)(C(=O)CO)[C@]1(C)C[C@@H](O)[C@@]3(Cl)[C@]2([H])CCC4=CC(=O)C=C[C@@]34C
- CAS Datenbank
- 4419-39-0(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| S-Sätze: |
24/25 |
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| WGK Germany |
3 |
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| HS Code |
29372900 |
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| Speicherklasse |
11 - Combustible Solids |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H361 |
Kann vermutlich die Fruchtbarkeit beeinträchtigen oder das Kind im Mutterleib schädigen. |
Reproduktionstoxizität |
Kategorie 2 |
Warnung |
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P201, P202, P281, P308+P313, P405,P501 |
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| Sicherheit |
| P201 |
Vor Gebrauch besondere Anweisungen einholen. |
| P202 |
Vor Gebrauch alle Sicherheitshinweise lesen und verstehen. |
| P281 |
Vorgeschriebene persönliche Schutzausrüstung verwenden. |
| P308+P313 |
BEI Exposition oder falls betroffen: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen. |
| P405 |
Unter Verschluss aufbewahren. |
| P501 |
Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Beclometason Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
White to Off-White Solid
Verwenden
Glucocorticoid. Beclomethasone is used in chronic asthma and allergic rhinitis. Antiallergic, antiasthmatic (inhalant). Anti-inflammatory (topical).
Definition
ChEBI: A 17alpha-hydroxy steroid that is prednisolone in which the hydrogens at the 9alpha and 16beta positions are substituted by a chlorine and a methyl group, respectively.
Biologische Funktion
The topical anti-inflammatory potency for beclomethasone dipropionate (BDP) is approximately 5,000 times greater than hydrocortisone, 500 times greater than
betamethasone or dexamethasone, and approximately five times greater than fluocinolone acetonide or
triamcinolone acetonide, as measured by vasoconstrictor assay.
Clinical Use
Beclomethasone, a 9α-chloro analogue of betamethasone, is a potent glucocorticoid with
approximately half the potency of its fluoro analogue. It is used topically as its dipropionate derivative in
inhalation aerosol therapy for asthma and rhinitis but not for
treatment of steroid-responsive dermatoses.
Beclometason Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Beclometason Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 159)Lieferanten
4419-39-0(Beclometason)Verwandte Suche:
9-Chlor-11β,17,21-trihydroxy-16β-methylpregna-1,4-dien-3,20-dion-17-propionat
Terbutalin
Ambroxol
16α(R),17-[Butylidenbis(oxy)]-11β,21-dihydroxypregna-1,4-dien-3,20-dion
9-Chlor-11β,17,21-trihydroxy-16β-methylpregna-1,4-dien-3,20-dion-21-propionat
Methylprednisolon
9-Chlor-11β-hydroxy-16β-methylpregna-1,4-dien-3,20-dion-17,21-dipropionat
Beclometason
- Pregna-1,4-diene-3,20-dione, 9-chloro-11,17,21-trihydroxy-16-methyl-, (11beta,16beta)-
- 9alpha-Chloro-16beta-methylprednisolone
- 9-Chloro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
- 9-Chloro-11beta,17,21-trihydroxy-16beta-methyl-pregna-1,4-diene-3,20-dione
- Beclomethasone Solution, 100ppm
- 9α-Chloro-16β-methyl-1,4-pregnadiene-11β,17α,21-triol-3,20-dione
- Beclomethasone solution,1000ppm
- Beclomethasone - 95% min
- Beclomethasone - 98% min
- 1,4-PREGNADIEN-9-ALPHA-CHLORO-16-BETA-METHYL-11-BETA, 17-ALPHA, 21-TRIOL-3,20-DIONE
- 9ALPHA-CHLORO-16BETA-METHYL-1,4-PREGNADIENE-11BETA,17ALPHA,21-TRIOL-3,20-DIONE
- BECLOMETHASONE
- BeclomethasoneDipropionateBase
- 9α-Chloro-16β-methyl-1,4-pregnadiene-11β,17α,21-triol-3,20-dione, 9α-Chloro-11β,17α,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione
- (8S,9R,10S,11S,13S,14S,16S,17R)-9-chloro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
- (8S,9R,10S,11S,13S,14S,16S,17R)-9-chloro-11,17-dihydroxy-17-(2-hydroxyethanoyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
- (8S,9R,10S,11S,13S,14S,16S,17R)-9-chloro-17-glycoloyl-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
- Beclomethasone,9α-Chloro-11β,17α,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione, 9α-Chloro-16β-methyl-1,4-pregnadiene-11β,17α,21-triol-3,20-dione
- 9-Chloro-16-methylpregna-1,4-diene-11,17,21-triol-3,20-dione
- Beclomethasone (base and/or unspecified salts)
- (9-α-Chloro-16-beta-methylprednisolone)
- (11,16)-9-Chloro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
- 9a-Chloro-16-methylprednisolone
- Becolvent
- BecloMethasone Solution
- 9α-Chloro-16β-Methylprednisolone
- 9-Chloro-11beta,17,21-trihydroxy-16
- BecL
- omethasone
- Pregna-1,4-diene-3,20-dione, 9-chloro-11,17,21-trihydroxy-16-methyl-, (11β,16β)-
- Beclomethasone in Methanol
- BECLOMETHASONE USP/EP/BP
- Pregna-1,4-diene-3,20-dione,9-chloro-11,17,21-trihydroxy-16-methyl-, (11b,16b)-
- Beclometasone (Beclometasone)
- 9-Chloro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione (Beclometasone)
- Beclometasone Dipropionate Imp. G (EP)
- 1, 4-PREGNADIEN-9α-CHLORO-16β-METHYL-11β, 17α, 21-TRIOL-3, 20-DIONE
- 9-Chloro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione (Beclometasone)
- Beclometasone, 10 mM in DMSO
- Beclomethasone，9-Chloro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
- Beclomethasone: 9-Chloro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione
- Beclometasone (Beclomethasone)
- Beclometasone
- Chloro methimazole
- Beclometasone Impurity W
- 4419-39-0
- 2092-13-4
- 3870-07-6
- C22H29ClO5
- Immunomodulators and Antibiotics
- Immune System Regulation
- Immune Cell Signaling and Blood
- BioChemical
- Cell Biology
- Cell Signaling and Neuroscience
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Steroids
