Monensin, Mononatriumsalz Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R25:Giftig beim Verschlucken.
R26/27/28:Sehr giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S22:Staub nicht einatmen.
Beschreibung
Monensin is a naturally occuring ionophorous antibiotic that preferentially forms complexes with monovalent cations to enable transport across lipid membranes. Through its ability to affect pH and the sodium-potassium balance of a cell, monensin can induce cell death in Gram-positive bacteria such as
Micrococcus,
Bacillus, and
Staphylococcus (MICs = 1-12.5 μg/ml), reduce proliferation of
P. falciparum and
Coccicdium protozoa, and also prevent replication of certain viruses.
Chemische Eigenschaften
LIGHT CREAM AMORPHOUS POWDER
Verwenden
Monensin sodium salt is used in potentiometric and spectroscopic studies of alkali metal ion complexes. Monensin (Na) is a polyether small molecule ionophore, capable of forming stable complexes to monovalent cations with specific affinity for Na+. Monensin presents a highly lipophilic scaffold around the bound ion, allowing movement of the complex through the lipid bilayer and consequent transport of the ion out of the cell. Excessive flux of ions out of the cell produces a cytotoxic effect and generates the antibiotic properties of Monensin.
Allgemeine Beschreibung
Monensin is a polyether ionophoric antibiotic, which is produced by
Streptomyces cinnamonensis. It is used to treat bacterial, fungal and parasitic infections. Monensin prevents the growth of colon cancer cells. It facilitates the transport of sodium and potassium ions between intracellular and extracellular spaces. Monensin prevents coccidiosisin poultry production.
läuterung methode
Crystallise it from EtOH/H2O [Cox et al. J Am Chem Soc 107 4297 1985].
Monensin, Mononatriumsalz Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
