Monensin sodium salt

Monensin sodium salt Properties

Melting point	267-269 C
alpha	57.3 º (c=4.0, in MeOH)
storage temp.	2-8°C
solubility	Soluble in methanol at 50mg/ml
form	Off-white to beige solid
color	White
BRN	4122200
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChIKey	XOIQMTLWECTKJL-BEMBKCOJSA-M
LogP	3.716 (est)
FDA UNII	1GS872GAFV
EPA Substance Registry System	Monensin, monosodium salt (22373-78-0)
UNSPSC Code	12352200

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06,GHS08,GHS09

Signal word

Danger

Hazard statements

H300-H319-H334-H373-H411

Precautionary statements

P260-P264-P273-P301+P310-P304+P340+P312-P305+P351+P338

target organs

Heart,muscle

Hazard Codes

T,T+

Risk Statements

25-26/27/28

Safety Statements

36/37/39-45-22

RIDADR

UN 3462 6.1/PG 2

WGK Germany

3

RTECS

JH2830000

HazardClass

6.1(a)

PackingGroup

II

HS Code

29419090

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials

Hazard Classifications

Acute Tox. 2 Oral
Aquatic Chronic 2
Eye Irrit. 2
STOT RE 2

NFPA 704

	0
3		0

Monensin sodium salt price More Price(60)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	PHR2775	Monensin sodium PharmaceuticalSecondaryStandard;CertifiedReferenceMaterial,certifiedrefer	22373-78-0	300MG	$184	2026-04-30	Buy
Sigma-Aldrich	46468	Monensin sodium salt hydrate VETRANAL	22373-78-0	100mg	$61.7	2026-04-30	Buy
Sigma-Aldrich	1445481	Monensin sodium United States Pharmacopeia (USP) Reference Standard	22373-78-0	200mg	$488	2026-04-30	Buy
TCI Chemical	M2573	Monensin Sodium Salt	22373-78-0	1G	$57	2026-04-30	Buy
TCI Chemical	M2573	Monensin Sodium Salt	22373-78-0	5G	$193	2026-04-30	Buy

Product number	Packaging	Price	Buy
PHR2775	300MG	$184	Buy
46468	100mg	$61.7	Buy
1445481	200mg	$488	Buy
M2573	1G	$57	Buy
M2573	5G	$193	Buy

Monensin sodium salt Chemical Properties, Uses, Production

Description

Monensin is a naturally occuring ionophorous antibiotic that preferentially forms complexes with monovalent cations to enable transport across lipid membranes. Through its ability to affect pH and the sodium-potassium balance of a cell, monensin can induce cell death in Gram-positive bacteria such as Micrococcus, Bacillus, and Staphylococcus (MICs = 1-12.5 μg/ml), reduce proliferation of P. falciparum and Coccicdium protozoa, and also prevent replication of certain viruses.

Chemical Properties

LIGHT CREAM AMORPHOUS POWDER

Uses

Poliether antibiotic. Coccidiostat.

Uses

antifungal

Uses

antibacterial

Uses

Monensin sodium salt is used in potentiometric and spectroscopic studies of alkali metal ion complexes. Monensin (Na) is a polyether small molecule ionophore, capable of forming stable complexes to monovalent cations with specific affinity for Na+. Monensin presents a highly lipophilic scaffold around the bound ion, allowing movement of the complex through the lipid bilayer and consequent transport of the ion out of the cell. Excessive flux of ions out of the cell produces a cytotoxic effect and generates the antibiotic properties of Monensin.

General Description

Monensin is a polyether ionophoric antibiotic, which is produced by Streptomyces cinnamonensis. It is used to treat bacterial, fungal and parasitic infections. Monensin prevents the growth of colon cancer cells. It facilitates the transport of sodium and potassium ions between intracellular and extracellular spaces. Monensin prevents coccidiosisin poultry production.

Biochem/physiol Actions

Na+ ionophore; blocks glycoprotein secretion; may induce catecholamine secretion from chromaffin cells. Useful in potentiometric and spectroscopic studies of alkali metal ion complexes.

storage

-20°C

Purification Methods

Crystallise it from EtOH/H2O [Cox et al. J Am Chem Soc 107 4297 1985].

References

[1] DANIEL AOWICKI Adam H. Structure and antimicrobial properties of monensin A and its derivatives: summary of the achievements.[J]. BioMed Research International, 2013: 742149. DOI:10.1155/2013/742149
[2] KARL-JOSEF KALLEN David A Paul Quinn. Monensin inhibits synthesis of plasma membrane sphingomyelin by blocking transport of ceramide through the Golgi: Evidence for two sites of sphingomyelin synthesis in BHK cells[J]. Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1993, 1166 2: Pages 305-308. DOI:10.1016/0005-2760(93)90111-l
[3] W F BOSS H H M D J Morré. Monensin-induced swelling of Golgi apparatus cisternae mediated by a proton gradient.[J]. European journal of cell biology, 1984, 34 1: 1-8.
[4] HILTON H. MOLLENHAUER Loyd D R D James Morré. Alteration of intracellular traffic by monensin; mechanism, specificity and relationship to toxicity[J]. Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 1990, 1031 2: Pages 225-246. DOI:10.1016/0304-4157(90)90008-z
[5] SUSANNE HAFNER S J L Michael Schmiech. The Cardenolide Glycoside Acovenoside A Interferes with Epidermal Growth Factor Receptor Trafficking in Non-Small Cell Lung Cancer Cells.[J]. ACS Applied Energy Materials, 2021: 611657. DOI:10.3389/fphar.2021.611657
[6] KENTARO OH-HASHI. Comparative Analysis of CREB3 and CREB3L2 Protein Expression in HEK293 Cells.[J]. International Journal of Molecular Sciences, 2021, 22 5. DOI:10.3390/ijms22052767

Monensin sodium salt synthesis

Synthesis of Monensin sodium salt from Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

Monensin sodium salt Preparation Products And Raw materials

Raw materials

Preparation Products

Monensin

Monensin sodium salt Suppliers

Global Suppliers ( 409)

Supplier	Tel	Email	Country	ProdList	Advantage
Wuhan Huajiu Pharmaceutical Technology Co.,Ltd.	027-59225746 18062681621	730880265@qq.com	China	4800	58
Hubei Weideli Chemical Reagent Co.，Ltd.	181-6332-1995 18062128043	18163321995@163.com	China	4810	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
Beijing Ouhe Technology Co., Ltd	13552068683 13522913783	2355560935@qq.com	China	11777	60
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
Nanjing MeiBo Biological Technology Co., Ltd.	025-58619198	sales@mbbio.com	China	319	60
XiaoGan ShenYuan ChemPharm co,ltd	15527621225; 15527621225	1791901229@qq.com	China	6742	52
Sinopharm Chemical Reagent Co,Ltd.	86-21-63210123	sj_scrc@sinopharm.com	China	9791	79
Hunan Hui Bai Shi Biotechnology Co., Ltd.	0731-85526065 13308475853	ivy@hnhbsj.com	China	7236	62

Supplier	Advantage
Wuhan Huajiu Pharmaceutical Technology Co.,Ltd.	58
Hubei Weideli Chemical Reagent Co.，Ltd.	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
Beijing Ouhe Technology Co., Ltd	60
Chemsky（shanghai）International Co.,Ltd.	50
Nanjing MeiBo Biological Technology Co., Ltd.	60
XiaoGan ShenYuan ChemPharm co,ltd	52
Sinopharm Chemical Reagent Co,Ltd.	79
Hunan Hui Bai Shi Biotechnology Co., Ltd.	62

View Latest Price from Monensin sodium salt manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-17	Monensin sodium salt 22373-78-0			0.99		RongNa Biotechnology Co.,Ltd
2026-09-10	Monensin sodium salt 22373-78-0	$42.00-58.00		98.74%	10g	TargetMol Chemicals Inc.
2026-09-02	Monensin sodium salt 22373-78-0	$1.00-3.00	1kg	99%		Henan Fengda Chemical Co., Ltd

Monensin sodium salt
22373-78-0
0.99
RongNa Biotechnology Co.,Ltd

Monensin sodium salt
22373-78-0
$42.00-58.00
98.74%
TargetMol Chemicals Inc.

Monensin sodium salt
22373-78-0
$1.00-3.00
99%
Henan Fengda Chemical Co., Ltd

Monensin sodium salt Spectrum

Monensin sodium salt(22373-78-0)MS Monensin sodium salt(22373-78-0)¹HNMR

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Pentacosanoic acid 2-[2-[(2-Ethylhexyl)oxy]ethoxy]ethanol GLYCOFUROL

1of4

Coban45 gamma,2,8-tetramethyl--furyl)-2-furyl)-9-hydroxy-beta-methoxy-alphmonosod methyl-5-(tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2h-pyran-2-yl)-2 monensin,monosodiumsalt Monensin,monosodiumsalt(9CI) Previouscas:22136-43-2 Sodiummonensin 2-[5-Ethyltetrahydro-5-[tetrahydro-3-Methyl-5-[tetrahydro-6-hydroxy-6-(hydroxyMethyl)-3,5-diMethyl-2H-pyran-2-yl]-2-furyl]-2-furyl]-9-hydroxy-β-Methoxy-α,γ,2,8-tetraMethyl- MONENSIN SODIUM (Monensin A is shown) 1,6-Dioxaspiro[4.5]decane-7-butyric acid, 2-[5-ethyltetrahydro-5-[tetrahydro-3-methyl-5-[tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl]-2-furyl]-2-furyl]-9-hydroxy-β-methoxy-α,γ,2,8-tetramethyl-, monosodium salt (8CI) Monensin sodium, 90-95% Monensin sodium 20/40%/90% 1,6-Dioxaspiro[4.5]decane-7-butyricacid,2-[5-ethyltetrahydro-5-[tetrahydro-3-methyl-5-[tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl]-2-furyl]-2-furyl]-9-hydroxy-.beta.-methoxy-.alpha.,.gamma.-2,8-tetramethyl-,monosodiumsal 1,6-Dioxaspiro[4.5]decane-7-butyricacid,2-[5-ethyltetrahydro-5-[tetrahydro-3-methyl-5-[tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl]-2-furyl]-2-furyl]-9-hydroxy-.beta.-methoxy-.alpha.,.gamma.-2,8-tetramethyl-,monosodiumsalt Coban MONENSIN SODIUM SALT 97% MONENSIN SODIUM SALT HYDRATE RUMENSIN MONENSINSODIUM,USP 1,6-Dioxaspiro[4.5] decane-7-butyric acid, 2-[5-ethyltetrahydro-5-[tetrahydro-3-methyl-5- [tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl]-2-furyl]-2-furyl]-9- hydroxy-.beta.-methoxy-.alpha.,.gamma.-2,8-tetramethyl-, monosodium salt Monensin sodium salt 4-[2-[5-Ethyl-5-[5-[6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-oxan-2-yl]-3-methyl-oxolan-2-yl]oxolan-2-yl]-9-hydroxy-2,8-dimethyl-1,6-dioxaspiro[4.5]dec-7-yl]-3-methoxy-2-methyl-pentanoic acid monosodium salt Monensin, sodium salt,97% 1,6-Dioxaspiro[4.5]decane-7-butyric acid, 2-[5-ethyltetrahydro-5-[tetrahydro-3-methyl-5-[tetrahydro-6-hydrox y-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl]-2-furyl]-2-furyl]-9-hydroxy-.beta.-metho xy-.alpha.,.gamma.,2,8-tetramethyl-, monosodium salt (8CI Sodium 4-[2-[2-Ethyl-3'-methyl-5'-(tetrahydro-6-hydroxy-6-hydroxymethyl-3,5-dimethylpyran-2-yl)perhydro-2,2'-bifuran-5-yl]-9-hydroxy-2,8-dimethyl-1,6-dioxaspiro[4.5]dec-7-yl}-3-methoxy-2-methylpentanoate Monensin Sodium (200 mg) Monensin sodium salt,Monensin A sodium salt Monensin sodiuM salt(Coban) Monensin sodium 40% 2-[5-Ethyltetrahydro-5-[tetrahydro-3-methyl-5-[tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl]-2-furyl]-2-furyl]-9-hydroxy-β-methoxy-α,γ,2,8-tetramethyl-1,6-Dioxaspiro[4.5]decane-7-butyric acid sodium salt Monensin, Sodium Salt, High Purity - CAS 22373-78-0 - Calbiochem Monensin sodium salt, 90+ % Sodium (2S,3R,4S)-4-[(2S,5R,7S,8R,9S)-2-[(2S,2'R,3'S,5R,5'R)-2-Ethyl-5'-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyltetrahydro-2H-pyran-2-yl]-3'-methyloctahydro-[2,2'-bifuran]-5-yl]-9-hydroxy-2,8-dimethyl- Monensin sodium salt USP/EP/BP Sodium (2S,3R,4S)-4-((2S,5R,7S,8R,9S)-2-((2S,2'R,3'S,5R,5'R)-2-ethyl-5'-((2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyltetrahydro-2H-pyran-2-yl)-3'-methyloctahydro-[2,2'-bifuran]-5-yl)-9-hydroxy-2,8-dimethyl-1,6-dioxaspiro[4.5]decan-7-yl)-3-methoxy-2-methylpentanoate Sodium (2S,3R,4S)-4-((2S,5R,7S,8R,9S)-2-((2S,2'R,3'S,5R,5'R)-2-ethyl-5'-((2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyltetrahydro-2H-pyran-2-yl)-3'-methyloctahydro-[2,2'-bifuran]-5-yl)-9-hydroxy-2,8-dimethyl-1,6-dioxaspiro[4.5]decan-7-yl)-3-methox Monensin Sodium Salt (MSN), 90-95% Monomycin sodium Sodium Monensin|||Monensin A sodium salt Monensin sodium salt, 90+ % in methanol monensin sodium salt in Methanol C15291000 Monensin sodium Monensin sodium salt, Na+ ionophore Monensin Sodium Bp2008/Usp28 Sodium Monensin (NSC 343257) Monensin sodium salt USP31 Monensin sodium (Synonyms: Monensin A sodium) Monensin sodium 100 μg/mL in Acetonitrile Monensinsodiumsal Monensin sodium salt (Standard) 22373-78-0 C36H61NaO11 C36H63NaO12 C36H61NaO11xH2O Antibiotics Antibiotics A to Z Antibiotics G-M BioChemical