4-(2,2,2-Trifluoroethoxy)phenylboronic acid
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- CAS-Nr.
- 886536-37-4
- Englisch Name:
- 4-(2,2,2-Trifluoroethoxy)phenylboronic acid
- Synonyma:
- (4-(2,2,2-Trifluoroethoxy);4-(2,2,2-trifluoroethoxy)phenyboronic acid;4-(2,2,2-Trifluoroethoxy)phenylboronic acid;4-(2,2,2-Trifluoroethoxy)benzeneboronic acid;4-(2,2,2-Trifluoroethoxy)benzeneboronicacid98%;4-(2,2,2-Trifluoroethoxy)benzeneboronic acid 98%;Boronic acid, B-[4-(2,2,2-trifluoroethoxy)phenyl]-;4-(2,2,2-Trifluoroethoxy)benzeneboronic acid, [4-(2,2,2-Trifluoroethoxy)phenyl]boronic acid
- CBNumber:
- CB8837293
- Summenformel:
- C8H8BF3O3
- Molgewicht:
- 219.95
- MOL-Datei:
- 886536-37-4.mol
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4-(2,2,2-Trifluoroethoxy)phenylboronic acid Eigenschaften
- Schmelzpunkt:
- 191-194℃
- Siedepunkt:
- 297.1±50.0 °C(Predicted)
- Dichte
- 1.35±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Aggregatzustand
- solid
- pka
- 8.58±0.16(Predicted)
- Farbe
- White
- InChI
- InChI=1S/C8H8BF3O3/c10-8(11,12)5-15-7-3-1-6(2-4-7)9(13)14/h1-4,13-14H,5H2
- InChIKey
- DWRAMTYYMNLVBD-UHFFFAOYSA-N
- SMILES
- B(C1=CC=C(OCC(F)(F)F)C=C1)(O)O
4-(2,2,2-Trifluoroethoxy)phenylboronic acid Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
4-(2,2,2-Trifluoroethoxy)phenylboronic acid can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.
Synthese
2- (2,2,2-trifluoroethoxy) bromobenzene 2558, isopropyl borate 2448 and methylTetrahydrofuran 1.5L was added to the reaction flask, and the reaction system was cooled to -15 ° C. 500 mL of isopropylmagnesium chloride in tetrahydrofuran (2.0 M) was added dropwise to the above reaction system and the internal temperature was controlled to not more than -10 ° C, and the reaction was kept at a low temperature for 1 hour. After completion of the reaction, 500 mL of 6M aqueous hydrochloric acid solution was added to terminate the reaction and the ρH- = 2 ~ 3 was added, and the mixture was thoroughly stirred and the aqueous phase was extracted with methyltetrahydrofuran (1.5 LX 1). The combined organic layers were washed with saturated brine (1.5 LX 2), and the combined organic layers were dried over anhydrous sodium sulfate and concentrated to give the crude product of 2- (2,2,2-trifluoroethoxy) phenylboronic acid. The crude product was recrystallized from 770 mL of isopropanol and water (10: 1 by volume) to give 187 g of 2- (2,2,2-trifluoroethoxy) phenylboronic acid in a molar yield of 85%.
4-(2,2,2-Trifluoroethoxy)phenylboronic acid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
4-(2,2,2-Trifluoroethoxy)phenylboronic acid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 126)Lieferanten
- 4-(2,2,2-Trifluoroethoxy)benzeneboronic acid
- 4-(2,2,2-Trifluoroethoxy)benzeneboronic acid 98%
- 4-(2,2,2-Trifluoroethoxy)benzeneboronicacid98%
- (4-(2,2,2-Trifluoroethoxy)
- Boronic acid, B-[4-(2,2,2-trifluoroethoxy)phenyl]-
- 4-(2,2,2-trifluoroethoxy)phenyboronic acid
- 4-(2,2,2-Trifluoroethoxy)benzeneboronic acid, [4-(2,2,2-Trifluoroethoxy)phenyl]boronic acid
- 4-(2,2,2-Trifluoroethoxy)phenylboronic acid
- 886536-37-4
- Boronate Ester
- Boronic Acid
- Potassium Trifluoroborate
- blocks
- BoronicAcids
- FluoroCompounds
