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RQ-00203078

RQ-00203078 Struktur
1254205-52-1
CAS-Nr.
1254205-52-1
Englisch Name:
RQ-00203078
Synonyma:
CS-1528;RQ-00203078;RQ-00203078 >=98% (HPLC);RQ-00203078, 10 mM in DMSO;RQ-00203078;RQ 00203078;RQ00203078.;4-(N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-(trifluoromethoxy)benzyl)sulfamoyl)benzoic acid;4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]({[4-(trifluoromethoxy)phenyl]methyl})sulfamoyl}benzoic acid;4-[[[3-Chloro-5-(trifluoromethyl)-2-pyridinyl][[4-(trifluoromethoxy)phenyl]methyl]amino]sulfonyl]benzoic acid;Benzoic acid, 4-[[[3-chloro-5-(trifluoromethyl)-2-pyridinyl][[4-(trifluoromethoxy)phenyl]methyl]amino]sulfonyl]-;Transient receptor potential channels,Ca2+,TRPM8,RQ00203078,TRP Channel,migration,inhibit,Inhibitor,RQ 00203078,RQ-00203078,oral,invasion,menthol
CBNumber:
CB93040792
Summenformel:
C21H13ClF6N2O5S
Molgewicht:
554.85
MOL-Datei:
1254205-52-1.mol
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RQ-00203078 Eigenschaften

Siedepunkt:
602.0±65.0 °C(Predicted)
Dichte
1.588±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
Löslichkeit
insoluble in H2O; ≥18.85 mg/mL in DMSO; ≥27.25 mg/mL in EtOH
Aggregatzustand
solid
pka
3.39±0.10(Predicted)
Farbe
White to off-white
InChI
InChI=1S/C21H13ClF6N2O5S/c22-17-9-14(20(23,24)25)10-29-18(17)30(11-12-1-5-15(6-2-12)35-21(26,27)28)36(33,34)16-7-3-13(4-8-16)19(31)32/h1-10H,11H2,(H,31,32)
InChIKey
IJGQFZYYEHCCIZ-UHFFFAOYSA-N
SMILES
C(O)(=O)C1=CC=C(S(N(C2=NC=C(C(F)(F)F)C=C2Cl)CC2=CC=C(OC(F)(F)F)C=C2)(=O)=O)C=C1
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
WGK Germany  WGK 3
Speicherklasse 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
Bildanzeige (GHS) Exclamation Mark (GHS07)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

RQ-00203078 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

RQ-00203078 is a selective antagonist of transient receptor potential melastatin 8 (TRPM8; IC50s = 8.3 and 5.8 nM in human and rat, respectively), while having little inhibitory action against TRPV1 (IC50 > 30 μM), TRPA1 (IC50 > 10 μM), TRPV4 (IC50 = 10 μM), or TRPM2 channels (IC50 > 10 μM). It attenuates icilin-induced wet-dog shakes in rats (ED50 = 0.65 mg/kg) after oral administration. RQ-00203078 has been shown to reduce HSC3 and HSC4 oral squamous carcinoma cell migration and invasion in vitro. TRPM8, a member of the TRP melastatin subgroup, plays a role in cold hyperalgesia and cold allodynia caused by disease conditions such as chemotherapy-induced peripheral neuropathy, diabetic neuropathy, migraine, and overactive bladder. It is also known to be involved in the tumor progression of certain carcinomas.

Verwenden

RQ 00203078 is a selective and orally active TRPM8 antagonist.

RQ-00203078 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

RQ-00203078 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 90)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shanghai Boyle Chemical Co., Ltd.
sales@boylechem.com China 2915 55
Haoyuan Chemexpress Co., Ltd. 021-58950125
info@chemexpress.com China 7545 61
MedChemexpress LLC 021-58955995
sales@medchemexpress.cn United States 4853 58
Bide Pharmatech Ltd. 400-164-7117 18317119277
 product02@bidepharm.com China 40000 60
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266
 China 4859 55
Shanghaizehan biopharma technology co., Ltd. 021-61350663 13052117465
 sales@zehanbiopharma.com China 989 55
Guangzhou Zhiya Chemdrugs Co.,Ltd 18122150900
 sculk28@163.com China 645 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
 info@efebio.com China 9799 58
Guangzhou QiYun Biotechnology Co., Ltd. 020-61288194 61288195
505721671@qq.com China 3853 58
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105
 2881489226@qq.com China 89667 60

1254205-52-1()Verwandte Suche:

Natriumdecanoat
  • RQ-00203078;RQ 00203078;RQ00203078.
  • CS-1528
  • 4-(N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-(trifluoromethoxy)benzyl)sulfamoyl)benzoic acid
  • RQ-00203078
  • 4-[[[3-Chloro-5-(trifluoromethyl)-2-pyridinyl][[4-(trifluoromethoxy)phenyl]methyl]amino]sulfonyl]benzoic acid
  • Benzoic acid, 4-[[[3-chloro-5-(trifluoromethyl)-2-pyridinyl][[4-(trifluoromethoxy)phenyl]methyl]amino]sulfonyl]-
  • RQ-00203078 >=98% (HPLC)
  • Transient receptor potential channels,Ca2+,TRPM8,RQ00203078,TRP Channel,migration,inhibit,Inhibitor,RQ 00203078,RQ-00203078,oral,invasion,menthol
  • 4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]({[4-(trifluoromethoxy)phenyl]methyl})sulfamoyl}benzoic acid
  • RQ-00203078, 10 mM in DMSO
  • 1254205-52-1
  • C21H13ClF6N2O5S
  • Inhibitors
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