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RQ-00203078

RQ-00203078 Structure
RQ-00203078 structure
CAS No.
1254205-52-1
Chemical Name:
RQ-00203078
Synonyms
CS-1528;RQ-00203078;RQ-00203078 >=98% (HPLC);RQ-00203078, 10 mM in DMSO;RQ-00203078;RQ 00203078;RQ00203078.;4-(N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-(trifluoromethoxy)benzyl)sulfamoyl)benzoic acid;4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]({[4-(trifluoromethoxy)phenyl]methyl})sulfamoyl}benzoic acid;4-[[[3-Chloro-5-(trifluoromethyl)-2-pyridinyl][[4-(trifluoromethoxy)phenyl]methyl]amino]sulfonyl]benzoic acid;Benzoic acid, 4-[[[3-chloro-5-(trifluoromethyl)-2-pyridinyl][[4-(trifluoromethoxy)phenyl]methyl]amino]sulfonyl]-;Transient receptor potential channels,Ca2+,TRPM8,RQ00203078,TRP Channel,migration,inhibit,Inhibitor,RQ 00203078,RQ-00203078,oral,invasion,menthol
CBNumber:
CB93040792
Molecular Formula:
C21H13ClF6N2O5S
Molecular Weight:
554.85
MDL Number:
MFCD29049510
MOL File:
1254205-52-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-18 07:23:31
Request For Quotation

RQ-00203078 Properties

Boiling point 602.0±65.0 °C(Predicted)
Density 1.588±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility insoluble in H2O; ≥18.85 mg/mL in DMSO; ≥27.25 mg/mL in EtOH
form solid
pka 3.39±0.10(Predicted)
color White to off-white
InChI InChI=1S/C21H13ClF6N2O5S/c22-17-9-14(20(23,24)25)10-29-18(17)30(11-12-1-5-15(6-2-12)35-21(26,27)28)36(33,34)16-7-3-13(4-8-16)19(31)32/h1-10H,11H2,(H,31,32)
InChIKey IJGQFZYYEHCCIZ-UHFFFAOYSA-N
SMILES C(O)(=O)C1=CC=C(S(N(C2=NC=C(C(F)(F)F)C=C2Cl)CC2=CC=C(OC(F)(F)F)C=C2)(=O)=O)C=C1
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
target organs Respiratory system
WGK Germany  WGK 3
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
0
2 0

RQ-00203078 price More Price(43)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML1602 RQ-00203078 ≥98% (HPLC) 1254205-52-1 5 mg $165 2026-04-30 Buy
Sigma-Aldrich SML1602 RQ-00203078 ≥98% (HPLC) 1254205-52-1 25 mg $660 2026-04-30 Buy
Cayman Chemical 19075 RQ-00203078 ≥98% 1254205-52-1 1mg $36 2026-04-30 Buy
Cayman Chemical 19075 RQ-00203078 ≥98% 1254205-52-1 5mg $135 2026-04-30 Buy
Cayman Chemical 19075 RQ-00203078 ≥98% 1254205-52-1 10mg $219 2026-04-30 Buy
Product number Packaging Price Buy
SML1602 5 mg $165 Buy
SML1602 25 mg $660 Buy
19075 1mg $36 Buy
19075 5mg $135 Buy
19075 10mg $219 Buy

RQ-00203078 Chemical Properties, Uses, Production

Description

RQ-00203078 is a selective antagonist of transient receptor potential melastatin 8 (TRPM8; IC50s = 8.3 and 5.8 nM in human and rat, respectively), while having little inhibitory action against TRPV1 (IC50 > 30 μM), TRPA1 (IC50 > 10 μM), TRPV4 (IC50 = 10 μM), or TRPM2 channels (IC50 > 10 μM). It attenuates icilin-induced wet-dog shakes in rats (ED50 = 0.65 mg/kg) after oral administration. RQ-00203078 has been shown to reduce HSC3 and HSC4 oral squamous carcinoma cell migration and invasion in vitro. TRPM8, a member of the TRP melastatin subgroup, plays a role in cold hyperalgesia and cold allodynia caused by disease conditions such as chemotherapy-induced peripheral neuropathy, diabetic neuropathy, migraine, and overactive bladder. It is also known to be involved in the tumor progression of certain carcinomas.

Uses

RQ 00203078 is a selective and orally active TRPM8 antagonist.

in vitro

in the menthol-induced calcium influx assay, rq-00203078 is a novel and highly potent trpm8 antagonist with human and rat ic50 values of 8.3 nm and 5.8 nm, respectively. rq-00203078 was highly selective over other trp channels [1].

in vivo

rq-00203078 demonstrated excellent activity in vivo in a dose dependent manner with an ed50 value of 0.65 mg/kg in the icilin-induced wet-dog shakes model in rats after oral administration [1].

IC 50

8.3 and 5.8 nm for htrpm8 and rtrpm8, respectively

storage

Store at +4°C

References

[1] ohmi m, shishido y, inoue t, ando k, fujiuchi a, yamada a, watanabe s, kawamura k. identification of a novel 2-pyridyl-benzensulfonamide derivative, rq-00203078, as a selective and orally active trpm8 antagonist. bioorg med chem lett. 2014 dec 1;24(23):5364-8.

RQ-00203078 Preparation Products And Raw materials

Raw materials

Preparation Products

RQ-00203078 Suppliers

Global Suppliers ( 90)
Supplier Tel Email Country ProdList Advantage
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2915 55
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7545 61
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4853 58
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4859 55
Shanghaizehan biopharma technology co., Ltd. 021-61350663 13052117465 sales@zehanbiopharma.com China 989 55
Guangzhou Zhiya Chemdrugs Co.,Ltd 18122150900 sculk28@163.com China 645 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9799 58
Guangzhou QiYun Biotechnology Co., Ltd. 020-61288194 61288195 505721671@qq.com China 3853 58
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Supplier Advantage
Shanghai Boyle Chemical Co., Ltd. 55
Haoyuan Chemexpress Co., Ltd. 61
MedChemexpress LLC 58
Bide Pharmatech Ltd. 60
Shanghai Lollane Biological Technology Co.,Ltd. 55
Shanghaizehan biopharma technology co., Ltd. 55
Guangzhou Zhiya Chemdrugs Co.,Ltd 55
Shanghai EFE Biological Technology Co., Ltd. 58
Guangzhou QiYun Biotechnology Co., Ltd. 58
Shanghai YuanYe Biotechnology Co., Ltd. 60

View Latest Price from RQ-00203078 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
RQ-00203078 pictures 2026-07-17 RQ-00203078
1254205-52-1
 $43.00-126.00 99.60% 10g TargetMol Chemicals Inc.
RQ-00203078 pictures 2019-12-31 RQ-00203078
1254205-52-1
 $1.00 1KG Min98% HPLC Career Henan Chemical Co
RQ-00203078 pictures 2019-12-31 RQ-00203078
1254205-52-1
 $1.00 1KG Min98% HPLC Career Henan Chemical Co
  • RQ-00203078 pictures
  • RQ-00203078
    1254205-52-1
  • $43.00-126.00
  • 99.60%
  • TargetMol Chemicals Inc.
  • RQ-00203078 pictures
  • RQ-00203078
    1254205-52-1
  • $1.00
  • Min98% HPLC
  • Career Henan Chemical Co
  • RQ-00203078 pictures
  • RQ-00203078
    1254205-52-1
  • $1.00
  • Min98% HPLC
  • Career Henan Chemical Co

RQ-00203078 Spectrum

RQ-00203078(1254205-52-1)1HNMR

1254205-52-1 (RQ-00203078) Related Search:

RQ-00203078 Decanoic-10,10,10-d3 acid crebanine Capric acid sodium salt 2,3-Dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one
songorine

1of2

RQ-00203078;RQ 00203078;RQ00203078. CS-1528 4-(N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-(trifluoromethoxy)benzyl)sulfamoyl)benzoic acid RQ-00203078 4-[[[3-Chloro-5-(trifluoromethyl)-2-pyridinyl][[4-(trifluoromethoxy)phenyl]methyl]amino]sulfonyl]benzoic acid Benzoic acid, 4-[[[3-chloro-5-(trifluoromethyl)-2-pyridinyl][[4-(trifluoromethoxy)phenyl]methyl]amino]sulfonyl]- RQ-00203078 >=98% (HPLC) Transient receptor potential channels,Ca2+,TRPM8,RQ00203078,TRP Channel,migration,inhibit,Inhibitor,RQ 00203078,RQ-00203078,oral,invasion,menthol 4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]({[4-(trifluoromethoxy)phenyl]methyl})sulfamoyl}benzoic acid RQ-00203078, 10 mM in DMSO 1254205-52-1 C21H13ClF6N2O5S Inhibitors