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3-Fluoro-4-methoxyphenylacetic acid

3-Fluoro-4-methoxyphenylacetic acid Structure
3-Fluoro-4-methoxyphenylacetic acid structure
CAS No.
452-14-2
Chemical Name:
3-Fluoro-4-methoxyphenylacetic acid
Synonyms
RARECHEM AL BO 1534;3F-4-METHOXYPHENYLESSIGSRE 5 G;4-(Carboxymethyl)-2-fluoroanisole;3-FLUORO-4-METHOXYPHENYLACETIC ACID;3-Fluoro-4-methyloxyphenylaceticacid;3-Fluoro-4-methoxyphenylaceticacid98%;Benzeneacetic acid, 3-fluoro-4-methoxy-;2-(3-fluoro-4-methoxyphenyl)acetic acid;3-Fluoro-4-methoxyphenylacetic acid 98%;4-(3-Fluoro-4-Methyloxyphenylacetic acid
CBNumber:
CB0104052
Molecular Formula:
C9H9FO3
Molecular Weight:
184.16
MDL Number:
MFCD00060353
MOL File:
452-14-2.mol
MSDS File:
SDS
Last updated:2026-05-27 17:22:49
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3-Fluoro-4-methoxyphenylacetic acid Properties

Melting point 111-113°C
Boiling point 309.0±27.0 °C(Predicted)
Density 1.269±0.06 g/cm3(Predicted)
storage temp. Store below +30°C.
form powder
pka 4.25±0.10(Predicted)
color White to off-white
InChI 1S/C9H9FO3/c1-13-8-3-2-6(4-7(8)10)5-9(11)12/h2-4H,5H2,1H3,(H,11,12)/p-1
InChIKey VURNBRZIFABCRU-UHFFFAOYSA-M
SMILES Fc1c(ccc(c1)CC(=O)[O-])OC
CAS DataBase Reference 452-14-2(CAS DataBase Reference)
UNSPSC Code 12352106
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)
GHS05
Signal word  Danger
Hazard statements  H318
Precautionary statements  P280-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36/37/39
WGK Germany  WGK 1
HazardClass  IRRITANT
HS Code  2918290090
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Dam. 1

3-Fluoro-4-methoxyphenylacetic acid price More Price(44)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.43872 3-Fluoro-4-methoxyphenylacetic acid ≥99% (HPLC) 452-14-2 5G $65 2026-04-30 Buy
Sigma-Aldrich 8.43872 3-Fluoro-4-methoxyphenylacetic acid ≥99% (HPLC) 452-14-2 10g $149 2023-01-07 Buy
Biosynth FF63976 3-Fluoro-4-methoxyphenylacetic acid 452-14-2 25g $150 2026-06-04 Buy
Biosynth FF63976 3-Fluoro-4-methoxyphenylacetic acid 452-14-2 10g $150 2026-06-04 Buy
Apolloscientific PC3802 3-Fluoro-4-methoxyphenylacetic acid 98% 452-14-2 5g $21 2026-06-04 Buy
Product number Packaging Price Buy
8.43872 5G $65 Buy
8.43872 10g $149 Buy
FF63976 25g $150 Buy
FF63976 10g $150 Buy
PC3802 5g $21 Buy

3-Fluoro-4-methoxyphenylacetic acid Chemical Properties, Uses, Production

Synthesis

3-fluoro-4-methoxyphenylacetonitrile (42 g, 0.25 mol) was heated for 5 h with 32 g of potassium hydroxide solution in 120 mL of ethanol and 30 mL of water. After the distillation of ethanol, the residue was diluted with water to a volume of 175 mL. The solution was filtered over the charcoal, and the filtrate was acidified by 50 percent H2SO4. The resulting solid was filtered and dried, yielding 3-Fluoro-4-methoxyphenylacetic acid.

References

[1] Collection of Czechoslovak Chemical Communications, 1990, vol. 55, # 1, p. 296 - 306
[2] European Journal of Medicinal Chemistry, 2014, vol. 87, p. 508 - 518
[3] Monatshefte fuer Chemie, 1955, vol. 86, p. 511,515
[4] DRP/DRBP Org.Chem.,
[5] Chemische Berichte, 1952, vol. 85, p. 577,580

3-Fluoro-4-methoxyphenylacetic acid synthesis

404-90-0
452-14-2
Synthesis of 3-Fluoro-4-methoxyphenylacetic acid from 3-Fluoro-4-methoxyphenylacetonitrile

3-Fluoro-4-methoxyphenylacetic acid Preparation Products And Raw materials

Raw materials

3-Fluoro-4-methoxybenzyl chloride Ethyl 3-fluoro-4-methoxybenzoylformate 3-Fluoro-4-methoxyphenylacetonitrile 2-Fluoroanisole Potassium hydroxide
Ethanol Water

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Preparation Products

3-Fluoro-4-methoxyphenethyl alcohol

3-Fluoro-4-methoxyphenylacetic acid Suppliers

Global Suppliers ( 141)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. +86-21-54098501 sales@sinch.com.cn China 11592 64
Jia Xing Isenchem Co.,Ltd 0573-85285100 18627885956 isenchem@163.com China 9389 66
Shanghai Longsheng chemical Co.,Ltd. 58099637 13585536065 sales@shlschem.com China 9880 59
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Nanjing Vital Chemical Co., Ltd. Please Send Email 18652950785 chemweiao@163.com China 4368 65
Tianjin Jinyuda Chemical Co., Ltd. 022-58013646 13011382049 sales@jinyudachem.com China 1976 55
Wuhan TCASChem Technology Co., Ltd. 027-86697669 13986148687 sales@tcaschem.com China 3997 55
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Wuhan Chemwish Technology Co., Ltd 56
Capot Chemical Co., Ltd 66
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. 64
Jia Xing Isenchem Co.,Ltd 66
Shanghai Longsheng chemical Co.,Ltd. 59
Shanghai Hanhong Scientific Co.,Ltd. 64
Nanjing Vital Chemical Co., Ltd. 65
Tianjin Jinyuda Chemical Co., Ltd. 55
Wuhan TCASChem Technology Co., Ltd. 55

View Latest Price from 3-Fluoro-4-methoxyphenylacetic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-(3-Fluoro-4-Methoxyphenyl)acetic acid pictures 2026-08-07 2-(3-Fluoro-4-Methoxyphenyl)acetic acid
452-14-2
 $1.00-1.60 1KG 99%+ 10000KG Shaanxi Dideu Medichem Co. Ltd
3-Fluoro-4-methoxyphenylacetic acid pictures 2026-08-07 3-Fluoro-4-methoxyphenylacetic acid
452-14-2
 $15.00-55.00 1KG 99% 20000KG Shaanxi Dideu Medichem Co. Ltd
3-FLUORO-4-METHOXYPHENYLACETIC ACID pictures 2021-08-11 3-FLUORO-4-METHOXYPHENYLACETIC ACID
452-14-2
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd

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3-FLUORO-4-METHOXYPHENYLACETIC ACID 3-Fluoro-4-methyloxyphenylaceticacid 3-Fluoro-4-methoxyphenylacetic acid 98% 3-Fluoro-4-methoxyphenylaceticacid98% RARECHEM AL BO 1534 2-(3-fluoro-4-methoxyphenyl)acetic acid 4-(3-Fluoro-4-Methyloxyphenylacetic acid 4-(Carboxymethyl)-2-fluoroanisole 2-(3-fluoro-4-methoxy-phenyl)ethanoic acid 3F-4-METHOXYPHENYLESSIGSRE 5 G Benzeneacetic acid, 3-fluoro-4-methoxy- 452-14-2 Fluorine series Aromatic Phenylacetic Acids and Derivatives Phenylacetic acid