Pyridine, 2-fluoro-3-methoxy- (9CI)
- CAS No.
- 163234-74-0
- Chemical Name:
- Pyridine, 2-fluoro-3-methoxy- (9CI)
- Synonyms
- 2-Fluoro-3-methoxypyridine;Pyridine,2-fluoro-3-Methoxy-;Pyridine, 2-fluoro-3-methoxy- (9CI)
- CBNumber:
- CB01047884
- Molecular Formula:
- C6H6FNO
- Molecular Weight:
- 127.12
- MDL Number:
- MFCD09834126
- MOL File:
- 163234-74-0.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P280-P301+P312-P362+P364 |
| HazardClass | IRRITANT |
| HS Code | 2933399990 |
Pyridine, 2-fluoro-3-methoxy- (9CI) price More Price(47)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC908496 | 2-Fluoro-3-methoxypyridine >98% | 163234-74-0 | 250mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC908496 | 2-Fluoro-3-methoxypyridine >98% | 163234-74-0 | 1g | $24 | 2026-06-04 | Buy |
| Apolloscientific | PC908496 | 2-Fluoro-3-methoxypyridine >98% | 163234-74-0 | 5g | $52 | 2026-06-04 | Buy |
| Apolloscientific | PC908496 | 2-Fluoro-3-methoxypyridine >98% | 163234-74-0 | 25g | $249 | 2026-06-04 | Buy |
| Apolloscientific | PC908496 | 2-Fluoro-3-methoxypyridine >98% | 163234-74-0 | 100g | $993 | 2026-06-04 | Buy |
Pyridine, 2-fluoro-3-methoxy- (9CI) Chemical Properties, Uses, Production
Synthesis
174669-74-0
74-88-4
163234-74-0
Synthesis of 2-fluoro-3-methoxypyridine (3): 2-fluoropyridin-3-ol (10 mmol), iodomethane (20 mmol) and potassium carbonate (20 mmol) were mixed in 100 mL of acetone and the reaction was carried out at reflux overnight. Upon completion of the reaction, the inorganic salts were removed by filtration and the solvent was removed by rotary evaporation. The crude product was purified by column chromatography (eluent ratio ethyl acetate:hexane = 1:5) to give a colorless liquid product [19] in 95% yield. The product characterization data were as follows: 1H NMR (CDCl3) δ 7.74-7.75 (m, 1H, C6-H), 7.26-7.31 (m, 1H, C4-H), 7.11-7.15 (m, 1H, C5-H), 3.91 (s, 3H, OMe); 19F NMR (CDCl3) δ 90.15 (s); ESI-MS: 128 (M + 1)+.
References
[1] Patent: EP3333163, 2018, A1. Location in patent: Paragraph 11407; 1408
[2] Patent: WO2009/103950, 2009, A1. Location in patent: Page/Page column 15; 16
[3] Journal of Medicinal Chemistry, 2012, vol. 55, # 5, p. 2185 - 2195
[4] Journal of Fluorine Chemistry, 2015, vol. 173, p. 29 - 34
[5] Patent: WO2016/89722, 2016, A1. Location in patent: Page/Page column 34
Pyridine, 2-fluoro-3-methoxy- (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| SynAsst Chemical. | 021-60343070 | China | 12731 | 55 | |
| Hebei Summedchem Co.,Ltd | 0319-5801333-8008 15630992918 | sales@summedchem.com | China | 1000 | 58 |
| Cochemical Ltd. | 029-86115547 17791676824 | sales@cochemical.com | China | 3014 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Mashilabs (Shanghai) Co.,Ltd. | 19916721580 | mafarm@126.com | China | 4534 | 58 |
| Hangzhou J&H Chemical Co., Ltd. | 0571-87396432 | sales@jhechem.com | China | 14905 | 59 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
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