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2-Fluoro-3-hydroxypyridine

2-Fluoro-3-hydroxypyridine structure

CAS No.: 174669-74-0

Chemical Name:: 2-Fluoro-3-hydroxypyridine

Synonyms: 2-Fluoropyridin-3-ol;CAS:174669-74-0;2-Fluoro-3-pyridinol;2-Fluoro-3-hydroxypy;2-FLUOROPYRIDINE-3-OL;3-Pyridinol, 2-fluoro-;2-Fluoro-3-hydroxytyrosine;3-FLUORO-2-HYDROXYPYRIDINE;3-fluoro-2-hdyroxypyridine;2-FLUORO-3-HYDROXYPYRIDINE

CBNumber:: CB5367690

Molecular Formula:: C5H4FNO

Molecular Weight:: 113.09

MDL Number:: MFCD03095042

MOL File:: 174669-74-0.mol

MSDS File:: SDS

Last updated:2025-09-16 17:17:29

Product description	Number	Pack Size	Price
2-Fluoro-3-hydroxypyridine >98.0%(GC)(T)	F0886	1g	$130
2-Fluoro-3-hydroxypyridine >98.0%(GC)(T)	F0886	5g	$440
2-Fluoro-3-hydroxypyridine	F591920	10g	$690
2-Fluoro-3-hydroxypyridine	4H01-3-08	100g	$464
2-Fluoro-3-hydroxypyridine	PC01476	100g	$290
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2-Fluoro-3-hydroxypyridine Properties

Melting point	131-133°C
Boiling point	306.7±22.0 °C(Predicted)
Density	1.325±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,Room Temperature
solubility	DMSO, Methanol
pka	4.92±0.10(Predicted)
form	Solid
color	Pale Yellow
CAS DataBase Reference	174669-74-0(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

Hazard Codes

Risk Statements

Safety Statements

HazardClass

IRRITANT

HS Code

29339900

NFPA 704

	1
2		0

2-Fluoro-3-hydroxypyridine price More Price(36)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	F0886	2-Fluoro-3-hydroxypyridine >98.0%(GC)(T)	174669-74-0	1g	$130	2025-07-31	Buy
TCI Chemical	F0886	2-Fluoro-3-hydroxypyridine >98.0%(GC)(T)	174669-74-0	5g	$440	2025-07-31	Buy
TRC	F591920	2-Fluoro-3-hydroxypyridine	174669-74-0	10g	$690	2021-12-16	Buy
SynQuest Laboratories	4H01-3-08	2-Fluoro-3-hydroxypyridine	174669-74-0	100g	$464	2021-12-16	Buy
Apolloscientific	PC01476	2-Fluoro-3-hydroxypyridine	174669-74-0	100g	$290	2021-12-16	Buy

Product number	Packaging	Price	Buy
F0886	1g	$130	Buy
F0886	5g	$440	Buy
F591920	10g	$690	Buy
4H01-3-08	100g	$464	Buy
PC01476	100g	$290	Buy

2-Fluoro-3-hydroxypyridine Chemical Properties,Uses,Production

Chemical Properties

Light yellow Cryst

Uses

As a pyridine derivative, 2-Fluoro-3-hydroxypyridine can be used in the preparation of imaging agents for nicotinic α4β2 receptor.

Uses

A pyridine derivative used in the preparation of imaging agents for nicotinic α4β2 receptor.

Synthesis

16867-03-1

174669-74-0

100 mL of pyridine hydrofluoride (Py-(HF)x, 70% hydrogen fluoride and 30% pyridine, purchased from Fluka) was cooled at 0°C. 3.7 g of 2-amino-3-hydroxypyridine (molecular weight: 110.12, 33.6 mmol) and 3 g of NaNO2 (molecular weight: 69.00, 43.5 mmol) were added to it in sequence, handling with caution. The reaction mixture was stirred at 0 °C for 1 h, followed by slow alkalinization with 10 N NaOH aqueous solution. The mixture was transferred to a partition funnel and extracted with EtOAc. The organic phases were combined, washed sequentially with water and brine, dried over Na2SO4 and concentrated to dryness. The residue was purified by silica gel column chromatography (eluent: heptane/EtOAc, 50/50) to give 2.5 g (65% yield) of solid 2-fluoro-3-hydroxypyridine, which did not require further purification. Thin layer chromatography (TLC) Rf value (EtOAc/heptane, 80/20): 0.65. melting point: 131 °C. 1H NMR (DMSO-d6, 298 K): δ 10.41 (s, 1H), 7.64 (td, J=1.7 and 4.7 Hz, 1H), 7.42 (dd, J=1.7,1.7 and 10.8 Hz, 1H). 7.17 (ddd, J=1.3,4.7 and 7.8 Hz, 1H).13C NMR (DMSO-d6, 298K): δ 152.8 (d, J1F-C=233 Hz, C), 140.2 (d, J2F-C=27 Hz, C), 135.6 (d, J3F-C=13 Hz, CH), 126.2 (d, J3F -C=5 Hz, CH), 122.6 (CH). Mass spectrum (DCI/NH4+): C5H4FNO: 131 [M+NH4+], 114 [M+H+]. Elemental analysis (C5H4FNO) is consistent with theoretical values for C, H, and N.

References

[1] Patent: US2005/249662, 2005, A1. Location in patent: Page/Page column 8-9
[2] Journal of Labelled Compounds and Radiopharmaceuticals, 1998, vol. 41, # 5, p. 451 - 463
[3] Journal of Labelled Compounds and Radiopharmaceuticals, 2008, vol. 51, # 9, p. 336 - 342
[4] Patent: US2010/29650, 2010, A1. Location in patent: Page/Page column 64
[5] Organic and Biomolecular Chemistry, 2015, vol. 13, # 12, p. 3667 - 3676

2-Fluoro-3-hydroxypyridine Preparation Products And Raw materials

Raw materials

2-Amino-3-hydroxypyridine 2-Fluoropyridine

Preparation Products

6-BROMO-2-FLUORO-3-METHOXYPYRIDINE F-A 85380

2-Fluoro-3-hydroxypyridine Suppliers

Global( 254)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29833	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Changzhou Ditong Chemical Co.,Ltd	+86-0519-88298848	info@edengenechem.com	China	2176	58
Shandong chuangyingchemical Co., Ltd.	18853181302	sale@chuangyingchem.com	CHINA	5906	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
Richest Group Ltd	18017061086	oled@richest-group.com	CHINA	5600	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17346	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23541	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
career henan chemical co	58
Accela ChemBio Inc.	58
Changzhou Ditong Chemical Co.,Ltd	58
Shandong chuangyingchemical Co., Ltd.	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Richest Group Ltd	58
SIMAGCHEM CORP	58
ANHUI WITOP BIOTECH CO., LTD	58

View Lastest Price from 2-Fluoro-3-hydroxypyridine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-11-18	2-Fluoro-3-hydroxypyridine 174669-74-0	US $1.10 / g	1g	99.00%	100 Tons Min	Dideu Industries Group Limited
2025-04-04	2-Fluoro-3-hydroxypyridine 174669-74-0	US $0.00-0.00 / KG	1KG	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
2021-07-13	2-Fluoro-3-hydroxypyridine 174669-74-0	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd

2-Fluoro-3-hydroxypyridine
174669-74-0
US $1.10 / g
99.00%
Dideu Industries Group Limited

2-Fluoro-3-hydroxypyridine
174669-74-0
US $0.00-0.00 / KG
98%
Henan Aochuang Chemical Co.,Ltd.

2-Fluoro-3-hydroxypyridine
174669-74-0
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

2-Fluoro-3-hydroxypyridine Spectrum

2-Fluoro-3-hydroxypyridine(174669-74-0)¹HNMR 2-Fluoro-3-hydroxypyridine(174669-74-0)FT-IR

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2-FLUORO-3-HYDROXYPYRIDINE 2-FLUOROPYRIDINE-3-OL 3-FLUORO-2-HYDROXYPYRIDINE 2-Fluoro-3-hydroxypyridine97% 3-Pyridinol,2-fluoro-(9CI) 2-Fluoropyridin-3-ol 3-fluoro-2-hdyroxypyridine 2-Fluoro-3-hydroxypy 2-Fluoro-3-pyridinol 2-Fluoro-3-hydroxytyrosine 2-Fluoro-3-hydroxypyridine> 3-Pyridinol, 2-fluoro- 2-Fluoro-3-hydroxypyridine ISO 9001：2015 REACH CAS:174669-74-0 174669-74-0 Fluorine series Pyridines Boronic Acid Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals HALIDE PYRIDINE