Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>2-Fluoro-3-hydroxypyridine

2-Fluoro-3-hydroxypyridine

2-Fluoro-3-hydroxypyridine Structure
2-Fluoro-3-hydroxypyridine structure
CAS No.
174669-74-0
Chemical Name:
2-Fluoro-3-hydroxypyridine
Synonyms
2-Fluoropyridin-3-ol;CAS:174669-74-0;2-Fluoro-3-pyridinol;2-Fluoro-3-hydroxypy;2-FLUOROPYRIDINE-3-OL;3-Pyridinol, 2-fluoro-;2-Fluoro-3-hydroxytyrosine;3-FLUORO-2-HYDROXYPYRIDINE;2-FLUORO-3-HYDROXYPYRIDINE;3-fluoro-2-hdyroxypyridine
CBNumber:
CB5367690
Molecular Formula:
C5H4FNO
Molecular Weight:
113.09
MDL Number:
MFCD03095042
MOL File:
174669-74-0.mol
MSDS File:
SDS
Last updated:2026-05-28 01:47:27
Product description Number Pack Size Price
2-Fluoro-3-hydroxypyridine >98.0%(GC)(T) F0886 1g $111
2-Fluoro-3-hydroxypyridine >98.0%(GC)(T) F0886 5g $374
2-Fluoro-3-hydroxypyridine ≥95% PC01476 5g $21
2-Fluoro-3-hydroxypyridine ≥95% PC01476 25g $55
2-Fluoro-3-hydroxypyridine ≥95% PC01476 100g $202
More product size
Request For Quotation

2-Fluoro-3-hydroxypyridine Properties

Melting point 131-133°C
Boiling point 306.7±22.0 °C(Predicted)
Density 1.325±0.06 g/cm3(Predicted)
storage temp. Inert atmosphere,Room Temperature
solubility DMSO, Methanol
pka 4.92±0.10(Predicted)
form Solid
color Pale Yellow
CAS DataBase Reference 174669-74-0(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P280g-P305+P351+P338
Hazard Codes  Xi,Xn
Risk Statements  22-36/37/38
Safety Statements  26-37
HazardClass  IRRITANT
HS Code  29339900
NFPA 704
1
2 0

2-Fluoro-3-hydroxypyridine price More Price(67)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical F0886 2-Fluoro-3-hydroxypyridine >98.0%(GC)(T) 174669-74-0 1g $111 2026-04-30 Buy
TCI Chemical F0886 2-Fluoro-3-hydroxypyridine >98.0%(GC)(T) 174669-74-0 5g $374 2026-04-30 Buy
Apolloscientific PC01476 2-Fluoro-3-hydroxypyridine ≥95% 174669-74-0 5g $21 2026-06-04 Buy
Apolloscientific PC01476 2-Fluoro-3-hydroxypyridine ≥95% 174669-74-0 25g $55 2026-06-04 Buy
Apolloscientific PC01476 2-Fluoro-3-hydroxypyridine ≥95% 174669-74-0 100g $202 2026-06-04 Buy
Product number Packaging Price Buy
F0886 1g $111 Buy
F0886 5g $374 Buy
PC01476 5g $21 Buy
PC01476 25g $55 Buy
PC01476 100g $202 Buy

2-Fluoro-3-hydroxypyridine Chemical Properties,Uses,Production

Chemical Properties

Light yellow Cryst

Uses

As a pyridine derivative, 2-Fluoro-3-hydroxypyridine can be used in the preparation of imaging agents for nicotinic α4β2 receptor.

Uses

A pyridine derivative used in the preparation of imaging agents for nicotinic α4β2 receptor.

Synthesis

2-Amino-3-hydroxypyridine

16867-03-1

2-Fluoro-3-hydroxypyridine

174669-74-0

100 mL of pyridine hydrofluoride (Py-(HF)x, 70% hydrogen fluoride and 30% pyridine, purchased from Fluka) was cooled at 0°C. 3.7 g of 2-amino-3-hydroxypyridine (molecular weight: 110.12, 33.6 mmol) and 3 g of NaNO2 (molecular weight: 69.00, 43.5 mmol) were added to it in sequence, handling with caution. The reaction mixture was stirred at 0 °C for 1 h, followed by slow alkalinization with 10 N NaOH aqueous solution. The mixture was transferred to a partition funnel and extracted with EtOAc. The organic phases were combined, washed sequentially with water and brine, dried over Na2SO4 and concentrated to dryness. The residue was purified by silica gel column chromatography (eluent: heptane/EtOAc, 50/50) to give 2.5 g (65% yield) of solid 2-fluoro-3-hydroxypyridine, which did not require further purification. Thin layer chromatography (TLC) Rf value (EtOAc/heptane, 80/20): 0.65. melting point: 131 °C. 1H NMR (DMSO-d6, 298 K): δ 10.41 (s, 1H), 7.64 (td, J=1.7 and 4.7 Hz, 1H), 7.42 (dd, J=1.7,1.7 and 10.8 Hz, 1H). 7.17 (ddd, J=1.3,4.7 and 7.8 Hz, 1H).13C NMR (DMSO-d6, 298K): δ 152.8 (d, J1F-C=233 Hz, C), 140.2 (d, J2F-C=27 Hz, C), 135.6 (d, J3F-C=13 Hz, CH), 126.2 (d, J3F -C=5 Hz, CH), 122.6 (CH). Mass spectrum (DCI/NH4+): C5H4FNO: 131 [M+NH4+], 114 [M+H+]. Elemental analysis (C5H4FNO) is consistent with theoretical values for C, H, and N.

References

[1] Patent: US2005/249662, 2005, A1. Location in patent: Page/Page column 8-9
[2] Journal of Labelled Compounds and Radiopharmaceuticals, 1998, vol. 41, # 5, p. 451 - 463
[3] Journal of Labelled Compounds and Radiopharmaceuticals, 2008, vol. 51, # 9, p. 336 - 342
[4] Patent: US2010/29650, 2010, A1. Location in patent: Page/Page column 64
[5] Organic and Biomolecular Chemistry, 2015, vol. 13, # 12, p. 3667 - 3676

2-Fluoro-3-hydroxypyridine Preparation Products And Raw materials

Raw materials

2-Amino-3-hydroxypyridine 2-Fluoropyridine

Preparation Products

6-BROMO-2-FLUORO-3-METHOXYPYRIDINE F-A 85380

2-Fluoro-3-hydroxypyridine Suppliers

Global( 253)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29626 60
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29766 58
Changzhou Ditong Chemical Co.,Ltd 		+86-0519-88298848 info@edengenechem.com China 2163 58
CONIER CHEM AND PHARMA LIMITED 		sales@conier.com China 49906 58
SIMAGCHEM CORP 		+86-5922680277 +86-13806087780 sale@simagchem.com China 17339 58
Dideu Industries Group Limited 		+8617392712697 1022@dideu.com China 29091 58
Baoji Guokang Healthchem Co., Ltd. 		+86-0917-3909592 +86-13892490616 gksales1@gk-bio.com China 9035 58
Dayang Chem (Hangzhou) Co.,Ltd. 		+86-0571-88938639 17705817739 info@dycnchem.com China 52693 58
CD Chemical Group Limited 		+86-13651442114 info@codchem.com China 17253 58
changzhou huayang technology co., ltd 		+8615250961469 2571773637@qq.com China 9628 58
Supplier Advantage
Capot Chemical Co.,Ltd. 		60
career henan chemical co 		58
Changzhou Ditong Chemical Co.,Ltd 		58
CONIER CHEM AND PHARMA LIMITED 		58
SIMAGCHEM CORP 		58
Dideu Industries Group Limited 		58
Baoji Guokang Healthchem Co., Ltd. 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58
CD Chemical Group Limited 		58
changzhou huayang technology co., ltd 		58

View Lastest Price from 2-Fluoro-3-hydroxypyridine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Fluoro-3-hydroxypyridine pictures 2026-08-20 2-Fluoro-3-hydroxypyridine
174669-74-0
 $1.10 1g 99.00% 100 Tons Min Dideu Industries Group Limited
2-Fluoro-3-hydroxypyridine pictures 2025-04-04 2-Fluoro-3-hydroxypyridine
174669-74-0
 1KG 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
2-Fluoro-3-hydroxypyridine pictures 2021-07-13 2-Fluoro-3-hydroxypyridine
174669-74-0
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd

2-Fluoro-3-hydroxypyridine Spectrum

2-Fluoro-3-hydroxypyridine(174669-74-0)1HNMR2-Fluoro-3-hydroxypyridine(174669-74-0)FT-IR

174669-74-0(2-Fluoro-3-hydroxypyridine)Related Search:

3-Aminopyridine Flupirtine Sulfasalazine Chromium picolinate 2-Fluoro-3-iodopyridine
3-Hydroxypyridine 4-Ethyl-5-fluoro-6-hydroxypyrimidine Hydroxy silicone oil 2-Fluoro-3-nitropyridine Fluorine
6-Bromo-2-fluoro-3-hydroxypyridine,6-Bromo-2-fluoro-3-hydroxypyridine 2-FLUORO-3-HYDROXY-6-PICOLINE 3-Fluoro-5-hydroxypyridine 4-BROMO-5-FLUORO-2-HYDROXYPYRIDINE,4-BROMO-5-FLUORO-2-HYDROXYPYRIDINE 2-FLUORO-5-HYDROXYPYRIDINE
2-CHLORO-3-FLUORO-5-HYDROXYPYRIDINE,2-CHLORO-3-FLUORO-5-HYDROXYPYRIDINE 3-FLUORO-2-HYDROXYPYRIDINE 5-BROMO-2-FLUORO-3-METHOXYPYRIDINE

1of4

2-FLUORO-3-HYDROXYPYRIDINE 2-FLUOROPYRIDINE-3-OL 3-FLUORO-2-HYDROXYPYRIDINE 2-Fluoro-3-hydroxypyridine97% 3-Pyridinol,2-fluoro-(9CI) 3-fluoro-2-hdyroxypyridine 2-Fluoro-3-hydroxypy 2-Fluoro-3-pyridinol 2-Fluoro-3-hydroxytyrosine 2-Fluoro-3-hydroxypyridine> 3-Pyridinol, 2-fluoro- 2-Fluoro-3-hydroxypyridine ISO 9001：2015 REACH CAS:174669-74-0 2-Fluoropyridin-3-ol 174669-74-0 Fluorine series Pyridines Boronic Acid Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals HALIDE PYRIDINE