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Isecarosmab

Isecarosmab structure

CAS No.: 2254082-79-4

Chemical Name:: Isecarosmab

Synonyms: Isecarosmab;Research Grade Isecarosmab;Research Grade Isecarosmab (DHK09401)

CBNumber:: CB010616969

Molecular Formula:

Molecular Weight:: 0

MDL Number:

MOL File:: Mol file

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-24 14:59:00

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Isecarosmab Properties

form	Liquid
color	Colorless to light yellow
FDA UNII	3DQY5VE61P

Isecarosmab price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-0628912	Isecarosmab 96.95%	2254082-79-4	1mg	$379	2026-06-04	Buy
ChemScene	CS-0628912	Isecarosmab 96.95%	2254082-79-4	5mg	$975	2026-06-04	Buy
ChemScene	CS-0628912	Isecarosmab 96.95%	2254082-79-4	10mg	$1571	2026-06-04	Buy
aablocks	AA02E65T	Isecarosmab >98%	2254082-79-4	1mg	$424	2026-06-03	Buy
aablocks	AA02E65T	Isecarosmab >98%	2254082-79-4	5mg	$1035	2026-06-03	Buy

Product number	Packaging	Price	Buy
CS-0628912	1mg	$379	Buy
CS-0628912	5mg	$975	Buy
CS-0628912	10mg	$1571	Buy
AA02E65T	1mg	$424	Buy
AA02E65T	5mg	$1035	Buy

Isecarosmab Chemical Properties, Uses, Production

Uses

Isecarosmab (M-6495) is an anti-ADAMTS monoclonal antibody (mAb) with a KD value of 3.65 pM. Isecarosmab has chondroprotective and anti-inflammatory activities. Isecarosmab can bind albumin to extend plasma half-life[1][2][3].

in vivo

Isecarosmab (0.1-10 mg/kg mg/kg, s.c, every third day) decreases the medial cartilage degeneration in Medial meniscus (DMM) mice^[1].

References

[1] Siebuhr AS, et al. The Anti-ADAMTS-5 Nanobody M6495 Protects Cartilage Degradation Ex Vivo. Int J Mol Sci. 2020 Aug 20;21(17):5992. DOI:10.3390/ijms21175992
[2] Sharma N, et al. Inflammation and joint destruction may be linked to the generation of cartilage metabolites of ADAMTS-5 through activation of toll-like receptors. Osteoarthritis Cartilage. 2020 May;28(5):658-668. DOI:10.1016/j.joca.2019.11.002
[3] C. Brenneis. Structural and symptomatic benefit of a half-live extended, systemically applied anti-ADAMTS-5 inhibitor (M6495). 2018. 26 (1), S299-S300.

Isecarosmab Preparation Products And Raw materials

Raw materials

Preparation Products

Isecarosmab Suppliers

Global Suppliers ( 6)

Supplier	Tel	Email	Country	ProdList	Advantage
Wuhan Chemstan Biotechnology Co., Ltd.	027-65317797 15926423062	422450190@qq.com	China	10305	58
Beijing Jin Ming Biotechnology Co., Ltd.	010-60605840	psaitong@jm-bio.com	China	27626	58
Biolab Reagents	027-65279366 18108604356	products@biolabreagent.com	China	9864	58
Atagenix Laboratories	027-87008169 17762441161	info@atagenix.com	China	9997	58
TargetMol	400-821-0310 15002144251	xuexiang.shao@tsbiochem.com	China	29128	58

Supplier	Advantage
Wuhan Chemstan Biotechnology Co., Ltd.	58
Beijing Jin Ming Biotechnology Co., Ltd.	58
Biolab Reagents	58
Atagenix Laboratories	58
TargetMol	58

2254082-79-4 (Isecarosmab) Related Search:

2,4-Imidazolidinedione, 5-cyclopropyl-5-[3-[(1R)-7,8-dichloro-1,2,4,5-tetrahydro-1-methyl-3H-3-benzazepin-3-yl]-3-oxopropyl]-, (5S)- L-Arginine, glycyl-L-prolyl-L-tryptophylglycyl-L-α-aspartyl-L-cysteinyl-L-seryl-L-arginyl-L-threonyl-L-cysteinylglycylglycylglycyl-L-valyl-L-glutaminyl-L-phenylalanyl-L-seryl-L-seryl- ZSNI-21 ADAMTS-5 5-FAM-tegeargsvillk(5-TAMRA)K-NH2 TFA

2,4-Imidazolidinedione, 5-cyclopropyl-5-[3-[(3S)-4-(3,5-difluorophenyl)-3-methyl-1-piperazinyl]-3-oxopropyl]-, (5S)-

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Isecarosmab Research Grade Isecarosmab (DHK09401) Research Grade Isecarosmab 2254082-79-4