4-chloro-2-methyl-6-phenylpyrimidine
- CAS No.
- 2915-15-3
- Chemical Name:
- 4-chloro-2-methyl-6-phenylpyrimidine
- Synonyms
- 4-chloro-2-methyl-6-phenylpyrimidine;Pyrimidine, 4-chloro-2-methyl-6-phenyl-
- CBNumber:
- CB01077146
- Molecular Formula:
- C11H9ClN2
- Molecular Weight:
- 204.66
- MDL Number:
- MOL File:
- Mol file
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
4-chloro-2-methyl-6-phenylpyrimidine price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | C377055 | 4-chloro-2-methyl-6-phenylpyrimidine | 2915-15-3 | 10mg | $45 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0297448 | 4-CHLORO-2-METHYL-6-PHENYLPYRIMIDINE 95.00% | 2915-15-3 | 5MG | $499.79 | 2021-12-16 | Buy |
| Chemenu | CM251955 | 4-Chloro-2-methyl-6-phenylpyrimidine 97% | 2915-15-3 | 5g | $505 | 2021-12-16 | Buy |
| Crysdot | CD11152683 | 4-Chloro-2-methyl-6-phenylpyrimidine 97% | 2915-15-3 | 5g | $535 | 2021-12-16 | Buy |
| Alichem | 2915153 | 4-Chloro-2-methyl-6-phenylpyrimidine | 2915-15-3 | 5g | $545.4 | 2021-12-16 | Buy |
4-chloro-2-methyl-6-phenylpyrimidine Chemical Properties,Uses,Production
Synthesis
62260-39-3
2915-15-3
Step 2: Synthesis of 4-chloro-2-methyl-6-phenylpyrimidine; A mixture of 2-methyl-6-phenylpyrimidin-4(3H)-one (15 g) with phosphorus trichloride (150 mL) was refluxed under nitrogen protection for 20 hours. Upon completion of the reaction, the excess phosphorous trichloride was removed by distillation. The residue was diluted with ethyl acetate (500 mL), washed sequentially with 10% sodium bicarbonate solution (100 mL), water and saturated saline, and the organic phase was dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure and the resulting crude product was purified by silica gel column chromatography (60-120 mesh) with petroleum ether/ethyl acetate (9:1, v/v) as eluent to afford the title compound 4-chloro-2-methyl-6-phenylpyrimidine 11 g (67% yield) as a light yellow solid. Melting point:57-59°C. Mass spectrum (MS): m/z measured value [M+H]+ 204.9. 1H NMR (400 MHz, DMSO-d6) δ: 2.50 (3H, s), 7.52-7.58 (3H, m), 8.08 (1H, s), 8.20-8.22 (2H, m).
References
[1] Synthesis, 1993, # 5, p. 478 - 481
[2] Australian Journal of Chemistry, 1984, vol. 37, # 1, p. 155 - 163
[3] Patent: WO2007/65940, 2007, A1. Location in patent: Page/Page column 41
[4] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 22, p. 6439 - 6442
4-chloro-2-methyl-6-phenylpyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
4-chloro-2-methyl-6-phenylpyrimidine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30229 | 58 |
| Zhengzhou TRIZ Pharmaceutical Technology Co., Ltd. | 19943855286 | triz-4@trizpharma.cn | China | 1936 | 56 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66028182 18626450290 | yftan@aikonchem.com | China | 16679 | 50 |
| Shanghai Sainty Biotechnology Co., Ltd. | 021-58957915 17721108391 | 907522080@qq.com | China | 999 | 55 |
| Combiphos (Shanghai) Biological Technology Co., Ltd. | 021-65232103 17602124823 | combiphos@vip.qq.com | China | 30000 | 58 |
| Nantong Kaisheng Biotechnology Co., Ltd. | 13951303301 | 2084934672@qq.com | China | 716 | 58 |
| Changzhou Yinghao Technology Development Co., Ltd | 15151934985 | sales@yingsapharm.com | China | 4558 | 58 |
| Shanghai Fine Biotech Co.，Ltd | 18717800556 | sales@finebiotech.com | China | 2182 | 58 |
| Jinan Xinhongtai Chemical Co. LTD | 13000000000 | jnxinhongtai@126.com | China | 19528 | 58 |
