ENPROFYLLINE
- CAS No.
- 41078-02-8
- Chemical Name:
- ENPROFYLLINE
- Synonyms
- d-4028;nilyph;Enprofilina;ENPROFYLLINE;ENPROPHYLLINE;Enprofyllilie;Enprofyllinum;3-PROPYLXANTHINE;3-Propylxanthfine;3-N-PROPYLXANTHINE
- CBNumber:
- CB0108540
- Molecular Formula:
- C8H10N4O2
- Molecular Weight:
- 194.19
- MDL Number:
- MFCD00043205
- MOL File:
- 41078-02-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 287-289 °C |
|---|---|
| Density | 1.38 g/cm3 |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble |
| form | solid |
| pka | 10.26±0.20(Predicted) |
| color | white |
| CAS DataBase Reference | 41078-02-8 |
| FDA UNII | DT7DT5E518 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H332-H302-H312 | |||||||||
| Precautionary statements | P280-P302+P352-P312-P322-P363-P501-P261-P271-P304+P340-P312-P264-P270-P301+P312-P330-P501 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 20/21/22 | |||||||||
| Safety Statements | 36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UO8439700 | |||||||||
| NFPA 704 |
|
ENPROFYLLINE price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 21746 | 3-Propylxanthine ≥95% | 41078-02-8 | 10mg | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 21746 | 3-Propylxanthine ≥95% | 41078-02-8 | 25mg | $86 | 2026-04-30 | Buy |
| Cayman Chemical | 21746 | 3-Propylxanthine ≥95% | 41078-02-8 | 50mg | $153 | 2026-04-30 | Buy |
| TRC | TRC-E557680-10MG | Enprofylline | 41078-02-8 | 10mg | $199 | 2026-06-03 | Buy |
| TRC | TRC-E557680-100MG | Enprofylline | 41078-02-8 | 100mg | $1559 | 2026-06-03 | Buy |
ENPROFYLLINE Chemical Properties,Uses,Production
Description
3-Propylxanthine is a xanthine derivative that antagonizes adenosine receptors (Kis = 44, 32, and 6.3 μM for A1, A2A, and A2B, respectively) and cAMP phosphodiesterase (Ki = 42 μM). Through these actions, 3-propylxanthine induces smooth muscle relaxation, blocks smooth muscle contraction and VEGF secretion driven by adenosine receptor agonists, and reduces bronchial hyperresponsiveness.
Uses
Bronchodilator.
Uses
Enprofylline is a xanthine lacking adenosine receptor antagonism.
Definition
ChEBI: Xanthine bearing a propyl substituent at position 3. A bronchodilator, it is used for the symptomatic treatment of asthma and chronic obstructive pulmonary disease, and in the management of cerebrovascular insufficiency, sickle cell disease, and diabetic n uropathy.
in vivo
Enprofylline increases heart rate (HR). Injection of Enprofylline (7.5 and 30 mg/kg) increases HR in male WT mouse from 529±23 to 590±20 and 562±20 after the low and high dose, respectively[3].
A high dose of Enprofylline (30 mg/kg) also decreases temperature compared with saline injection in female (but not in males) WT mice, but a low dose (7.5 mg/kg) has little effect on mouse temperature[3].
| Animal Model: | A1RKO mice (were cross-bred to C57BL/6 mice for six generations) and A2ARKO mice (were backcrossed to C57BL/6 mice for more than 10 generations)[3] |
| Dosage: | 30 mg/kg |
| Administration: | Intraperitoneally injected (bolus) at 2-h intervals |
| Result: | Increased HR in male WT mouse from 529±23 to 590±20 and 562±20 after the low (7.5 mg/kg) and high dose (30 mg/kg), respectively. |
IC 50
A2B receptor: 7 μM (Ki)
References
[1] J LINDEN. Characterization of human A(2B) adenosine receptors: radioligand binding, western blotting, and coupling to G(q) in human embryonic kidney 293 cells and HMC-1 mast cells.[J]. Molecular Pharmacology, 1999, 56 4: 705-713.
[2] K. OGAWA T. S K Takagi. Mechanism of xanthine-induced relaxation of guinea-pig isolated trachealis muscle[J]. British Journal of Pharmacology, 1989, 97 2: 542-546. DOI: 10.1111/j.1476-5381.1989.tb11983.x
[3] U SCHWABE M J L D Ukena. Xanthine derivatives as antagonists at A1 and A2 adenosine receptors.[J]. Naunyn-Schmiedeberg’s archives of pharmacology, 1985, 330 3: 212-221. DOI: 10.1007/bf00572436
[4] BIRGITTE HIER. Contraction-induced secretion of VEGF from skeletal muscle cells is mediated by adenosine.[J]. American journal of physiology. Heart and circulatory physiology, 2010: H857-62. DOI: 10.1152/ajpheart.00082.2010
[5] G H KOTER. Effect of theophylline and enprofylline on bronchial hyperresponsiveness.[J]. Thorax, 1989, 44 12: 1022-1026. DOI: 10.1136/thx.44.12.1022
ENPROFYLLINE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2110 | 70 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Beijing HuaMeiHuLiBiological Chemical | 010-56205725 | waley188@sohu.com | China | 12323 | 58 |
| Finetech Industry Limited | 027-87465837 19945049750 | sales@finetechnology-ind.com | China | 9331 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Aikon International Limited | 025-58859352 13913916777 | dt3@aikonchem.com | China | 15490 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 400-920-5774 | sales@glpbio.cn | China | 6705 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
View Lastest Price from ENPROFYLLINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-15 | Enprofylline
41078-02-8
|
$59.00-152.00 | 98.37% | 10g | TargetMol Chemicals Inc. | ||
 |
2020-01-15 | ENPROFYLLINE
41078-02-8
|
$1.00 | 1KG | 99.0% | 100kg | Career Henan Chemical Co |
-
- Enprofylline
41078-02-8
- $59.00-152.00
- 98.37%
- TargetMol Chemicals Inc.
-
- ENPROFYLLINE
41078-02-8
- $1.00
- 99.0%
- Career Henan Chemical Co
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