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2-Hydroxy-5-methyl-3-nitropyridine

2-Hydroxy-5-methyl-3-nitropyridine structure

CAS No.: 7464-14-4

Chemical Name:: 2-Hydroxy-5-methyl-3-nitropyridine

Synonyms: 5-Methyl-3-nitro-2-pyridinol;2-HYDROXY-3-NITRO-5-PICOLINE;5-Methyl-3-nitropyridin-2-ol;6-Hydroxy-5-nitro-3-picoline;3-(NITRO)-5-METHYLPYRIDIN-2-OL;5-Methyl-3-nitro-2(1H)-pyridone;5-Methyl-3-nitropyridin-2(1H)-one;5-METHYL-3-NITRO-2(1H)-PYRIDINONE;2-HYDROXY-3-NITRO-5-METHYLPYRIDINE;2-HYDROXY-5-METHYL-3-NITROPYRIDINE

CBNumber:: CB0109633

Molecular Formula:: C6H6N2O3

Molecular Weight:: 154.12

MDL Number:: MFCD02070021

MOL File:: 7464-14-4.mol

MSDS File:: SDS

Last updated:2026-05-27 17:04:56

Product description	Number	Pack Size	Price
2-Hydroxy-5-methyl-3-nitropyridine 97%	551910	5g	$50
2-Hydroxy-5-methyl-3-nitropyridine >98.0%(GC)(T)	H1483	5g	$85
2-Hydroxy-5-methyl-3-nitropyridine >98.0%(GC)(T)	H1483	25g	$260
2-Hydroxy-5-methyl-3-nitropyridine	HAA46414	100g	$250
2-Hydroxy-5-methyl-3-nitropyridine 98%	OR5572	1g	$21
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2-Hydroxy-5-methyl-3-nitropyridine Properties

Melting point	179 °C (dec.) (lit.)
Boiling point	353.3±35.0 °C(Predicted)
Density	1.24 g/mL at 25 °C(lit.)
Flash point	179 °C
storage temp.	2-8°C
solubility	soluble in Dimethylformamide
pka	8.78±0.10(Predicted)
form	powder to crystal
color	White to Yellow
InChI	1S/C6H6N2O3/c1-4-2-5(8(10)11)6(9)7-3-4/h2-3H,1H3,(H,7,9)
InChIKey	QAINEQVHSHARMD-UHFFFAOYSA-N
SMILES	Cc1cnc(O)c(c1)[N+]([O-])=O
CAS DataBase Reference	7464-14-4(CAS DataBase Reference)
UNSPSC Code	12352100

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

Hazard Note

Irritant

HS Code

2933399990

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	0
2		0

2-Hydroxy-5-methyl-3-nitropyridine price More Price(52)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	551910	2-Hydroxy-5-methyl-3-nitropyridine 97%	7464-14-4	5g	$50	2023-01-07	Buy
TCI Chemical	H1483	2-Hydroxy-5-methyl-3-nitropyridine >98.0%(GC)(T)	7464-14-4	5g	$85	2026-04-30	Buy
TCI Chemical	H1483	2-Hydroxy-5-methyl-3-nitropyridine >98.0%(GC)(T)	7464-14-4	25g	$260	2026-04-30	Buy
Biosynth	HAA46414	2-Hydroxy-5-methyl-3-nitropyridine	7464-14-4	100g	$250	2026-06-04	Buy
Apolloscientific	OR5572	2-Hydroxy-5-methyl-3-nitropyridine 98%	7464-14-4	1g	$21	2026-06-04	Buy

Product number	Packaging	Price	Buy
551910	5g	$50	Buy
H1483	5g	$85	Buy
H1483	25g	$260	Buy
HAA46414	100g	$250	Buy
OR5572	1g	$21	Buy

2-Hydroxy-5-methyl-3-nitropyridine Chemical Properties,Uses,Production

Description

2-Hydroxy-5-methyl-3-nitropyridine (HMPN) is an organosynthetic compound that can be used as a feedstock for the synthesis of other compounds or as a biological inhibitor, such as in the preparation of 2-chloro-5-methyl-3-nitropyridine and transglutaminase 2 (tg2) inhibitors. It reacts with molybdenum and chloride. It is able to react with molybdenum and chloride, and it is able to increase the reaction yield and time. It is also used to explain its reactivity with xylene.

Chemical Properties

Powder or crystalline

Uses

2-Hydroxy-5-methyl-3-nitropyridine may be used in the preparation of 2-chloro-5-methyl-3-nitropyridine via chlorination, using thionyl chloride. It may also be used is preparing proteasome inhibitors containing 5-methylpyridin-2(1H)-one moiety.

Synthesis

1603-41-4

7464-14-4

Example 3: Synthesis of 2-(1-vinylimino)-5-carbamoyl-3-nitropyridine (Compound III) Reagents and conditions: (i) HNO3/H2SO4, followed by NaNO2. (ii) POCl3. (iii) Na2Cr2O7; (iv) SOCl2 (iv) SOCl2, followed by NH4OH/THF. (v) Aziridine. Steps for the synthesis of compound 14: 1. cool concentrated sulfuric acid (25 mL) in an ice bath, slowly add feedstock compound 13 (5 g, 0.0462 mol) and cool to 0 °C. 2. Slowly add 6 mL of a mixture of concentrated sulfuric acid (98%) and concentrated nitric acid (72%) in a volume ratio of 1:1 and keep the reaction temperature at 0-5 °C for 2 hours. 3. the reaction solution was poured into 100mL of ice water, 6g of sodium nitrite was added and stirring was continued in an ice bath for 4 hours. 4. The solid was precipitated, filtered and the filter cake was dried to give 4.4 g of compound 14 in 61.9% yield. 5. The melting point was determined to be 177-178 °C (water) (literature reports melting points of 178-180 °C) [J.O.C., 1944, 14, 328-332].

References

[1] Patent: EP2366691, 2011, A1. Location in patent: Page/Page column 8-9
[2] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 5, p. 985 - 995
[3] Bioorganic and Medicinal Chemistry, 2008, vol. 16, # 23, p. 9948 - 9956

2-Hydroxy-5-methyl-3-nitropyridine Preparation Products And Raw materials

Raw materials

2-Amino-5-methylpyridine Sodium nitrite Nitric acid Sodium hydroxide Sulfuric acid

Preparation Products

5-NITRONICOTINIC ACID 2-BROMO-3-NITRO-5-METHYL PYRIDINE Pyridine, 5-methyl-2-(1-methylethoxy)-3-nitro-

2-Hydroxy-5-methyl-3-nitropyridine Suppliers

Global( 228)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10403	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10821	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29792	58
Antai Fine Chemical Technology Co.,Limited	18503026267	info@antaichem.com	CHINA	9636	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
Nanjing Fred Technology Co., Ltd.	+86-02584696168 15380713688	Austin@fredchem.cn	CHINA	865	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23541	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Shenzhen Nexconn Pharmatechs Ltd	58
Alchem Pharmtech,Inc.	58
Wuhan Chemwish Technology Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Antai Fine Chemical Technology Co.,Limited	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Nanjing Fred Technology Co., Ltd.	58
ANHUI WITOP BIOTECH CO., LTD	58

View Lastest Price from 2-Hydroxy-5-methyl-3-nitropyridine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-11-18	2-Hydroxy-5-methyl-3-nitropyridine 7464-14-4	$1.10	1g	99.00%	100 Tons Min	Dideu Industries Group Limited
2021-08-11	2-Hydroxy-5-methyl-3-nitropyridine 7464-14-4	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd
2020-05-26	2-Hydroxy-5-methyl-3-nitropyridine 7464-14-4		1KG	99.0%	500 MT	Shaanxi Dideu Medichem Co. Ltd

2-Hydroxy-5-methyl-3-nitropyridine
7464-14-4
$1.10
99.00%
Dideu Industries Group Limited

2-Hydroxy-5-methyl-3-nitropyridine
7464-14-4
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

2-Hydroxy-5-methyl-3-nitropyridine
7464-14-4
99.0%
Shaanxi Dideu Medichem Co. Ltd

2-Hydroxy-5-methyl-3-nitropyridine Spectrum

2-Hydroxy-5-methyl-3-nitropyridine(7464-14-4)¹HNMR 2-Hydroxy-5-methyl-3-nitropyridine(7464-14-4)IR

7464-14-4(2-Hydroxy-5-methyl-3-nitropyridine)Related Search:

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4-Hydroxy-3-nitropyridine Basic Violet 1 2-Methyl-3-nitropyridine

1of4

2-HYDROXY-5-METHYL-3-NITROPYRIDINE 2-HYDROXY-3-NITRO-5-METHYLPYRIDINE 2-HYDROXY-3-NITRO-5-PICOLINE 5-METHYL-3-NITRO-2(1H)-PYRIDINONE 3-(NITRO)-5-METHYLPYRIDIN-2-OL 5-Methyl-3-nitropyridin-2-ol 2-HYDROXY-3-NITRO-5-PICOLINE (2-HYDROXY-5-METHYL-3-NITROPYRIDINE) 2-Hydroxy-5-methyl-3-nitropyridine 98% 5-Methyl-3-nitropyridin-2(1H)-one 5-Methyl-3-nitro-2(1H)-pyridone 5-Methyl-3-nitro-2-pyridinol 6-Hydroxy-5-nitro-3-picoline 2-Hydroxy-5-methyl-3-nitropyridine ISO 9001：2015 REACH 2(1H)-Pyridinone, 5-methyl-3-nitro- 7464-14-4 Heterocyclic Building Blocks Pyridines Building Blocks C6 Heterocyclic Building Blocks blocks NitroCompounds Pyridines Pyridine compounds of pyridine C6