Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>2-Hydroxy-5-methyl-3-nitropyridine

2-Hydroxy-5-methyl-3-nitropyridine

2-Hydroxy-5-methyl-3-nitropyridine Structure
2-Hydroxy-5-methyl-3-nitropyridine structure
CAS No.
7464-14-4
Chemical Name:
2-Hydroxy-5-methyl-3-nitropyridine
Synonyms
5-Methyl-3-nitro-2-pyridinol;2-HYDROXY-3-NITRO-5-PICOLINE;5-Methyl-3-nitropyridin-2-ol;6-Hydroxy-5-nitro-3-picoline;3-(NITRO)-5-METHYLPYRIDIN-2-OL;5-Methyl-3-nitro-2(1H)-pyridone;5-Methyl-3-nitropyridin-2(1H)-one;5-METHYL-3-NITRO-2(1H)-PYRIDINONE;2-HYDROXY-3-NITRO-5-METHYLPYRIDINE;2-HYDROXY-5-METHYL-3-NITROPYRIDINE
CBNumber:
CB0109633
Molecular Formula:
C6H6N2O3
Molecular Weight:
154.12
MDL Number:
MFCD02070021
MOL File:
7464-14-4.mol
MSDS File:
SDS
Last updated:2026-05-27 17:04:56
Request For Quotation

2-Hydroxy-5-methyl-3-nitropyridine Properties

Melting point 179 °C (dec.) (lit.)
Boiling point 353.3±35.0 °C(Predicted)
Density 1.24 g/mL at 25 °C(lit.)
Flash point 179 °C
storage temp. 2-8°C
solubility soluble in Dimethylformamide
pka 8.78±0.10(Predicted)
form powder to crystal
color White to Yellow
InChI 1S/C6H6N2O3/c1-4-2-5(8(10)11)6(9)7-3-4/h2-3H,1H3,(H,7,9)
InChIKey QAINEQVHSHARMD-UHFFFAOYSA-N
SMILES Cc1cnc(O)c(c1)[N+]([O-])=O
CAS DataBase Reference 7464-14-4(CAS DataBase Reference)
UNSPSC Code 12352100

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
Hazard Note  Irritant
HS Code  2933399990
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
0
2 0

2-Hydroxy-5-methyl-3-nitropyridine price More Price(46)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 551910 2-Hydroxy-5-methyl-3-nitropyridine 97% 7464-14-4 5g $50 2023-01-07 Buy
TCI Chemical H1483 2-Hydroxy-5-methyl-3-nitropyridine >98.0%(GC)(T) 7464-14-4 5g $85 2026-04-30 Buy
TCI Chemical H1483 2-Hydroxy-5-methyl-3-nitropyridine >98.0%(GC)(T) 7464-14-4 25g $260 2026-04-30 Buy
Biosynth HAA46414 2-Hydroxy-5-methyl-3-nitropyridine 7464-14-4 100g $250 2026-06-04 Buy
Apolloscientific OR5572 2-Hydroxy-5-methyl-3-nitropyridine 98% 7464-14-4 1g $21 2026-06-04 Buy
Product number Packaging Price Buy
551910 5g $50 Buy
H1483 5g $85 Buy
H1483 25g $260 Buy
HAA46414 100g $250 Buy
OR5572 1g $21 Buy

2-Hydroxy-5-methyl-3-nitropyridine Chemical Properties, Uses, Production

Description

2-Hydroxy-5-methyl-3-nitropyridine (HMPN) is an organosynthetic compound that can be used as a feedstock for the synthesis of other compounds or as a biological inhibitor, such as in the preparation of 2-chloro-5-methyl-3-nitropyridine and transglutaminase 2 (tg2) inhibitors. It reacts with molybdenum and chloride. It is able to react with molybdenum and chloride, and it is able to increase the reaction yield and time. It is also used to explain its reactivity with xylene.

Chemical Properties

Powder or crystalline

Uses

2-Hydroxy-5-methyl-3-nitropyridine may be used in the preparation of 2-chloro-5-methyl-3-nitropyridine via chlorination, using thionyl chloride. It may also be used is preparing proteasome inhibitors containing 5-methylpyridin-2(1H)-one moiety.

Synthesis

2-Amino-5-methylpyridine

1603-41-4

2-Hydroxy-5-methyl-3-nitropyridine

7464-14-4

Example 3: Synthesis of 2-(1-vinylimino)-5-carbamoyl-3-nitropyridine (Compound III) Reagents and conditions: (i) HNO3/H2SO4, followed by NaNO2. (ii) POCl3. (iii) Na2Cr2O7; (iv) SOCl2 (iv) SOCl2, followed by NH4OH/THF. (v) Aziridine. Steps for the synthesis of compound 14: 1. cool concentrated sulfuric acid (25 mL) in an ice bath, slowly add feedstock compound 13 (5 g, 0.0462 mol) and cool to 0 °C. 2. Slowly add 6 mL of a mixture of concentrated sulfuric acid (98%) and concentrated nitric acid (72%) in a volume ratio of 1:1 and keep the reaction temperature at 0-5 °C for 2 hours. 3. the reaction solution was poured into 100mL of ice water, 6g of sodium nitrite was added and stirring was continued in an ice bath for 4 hours. 4. The solid was precipitated, filtered and the filter cake was dried to give 4.4 g of compound 14 in 61.9% yield. 5. The melting point was determined to be 177-178 °C (water) (literature reports melting points of 178-180 °C) [J.O.C., 1944, 14, 328-332].

References

[1] Patent: EP2366691, 2011, A1. Location in patent: Page/Page column 8-9
[2] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 5, p. 985 - 995
[3] Bioorganic and Medicinal Chemistry, 2008, vol. 16, # 23, p. 9948 - 9956

2-Hydroxy-5-methyl-3-nitropyridine Preparation Products And Raw materials

Raw materials

2-Amino-5-methylpyridine Sodium nitrite Nitric acid Sodium hydroxide Sulfuric acid

Preparation Products

5-Nitronicotinic acid 2-Bromo-3-nitro-5-methyl pyridine Pyridine, 5-methyl-2-(1-methylethoxy)-3-nitro-

2-Hydroxy-5-methyl-3-nitropyridine Suppliers

Global Suppliers ( 225)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
INTATRADE GmbH +49 3493/605464 sales@intatrade.de Germany 3563 66
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. +86-21-54098501 sales@sinch.com.cn China 11592 64
Shanghai Longsheng chemical Co.,Ltd. 58099637 13585536065 sales@shlschem.com China 9880 59
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Syntechem Co.,Ltd info@syntechem.com China 12973 57
Supplier Advantage
J & K SCIENTIFIC LTD. 76
INTATRADE GmbH 66
Energy Chemical 61
Wuhan Chemwish Technology Co., Ltd 56
Capot Chemical Co., Ltd 66
JinYan Chemicals(ShangHai) Co.,Ltd. 60
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. 64
Shanghai Longsheng chemical Co.,Ltd. 59
Shanghai Hanhong Scientific Co.,Ltd. 64
Syntechem Co.,Ltd 57

View Latest Price from 2-Hydroxy-5-methyl-3-nitropyridine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Hydroxy-5-methyl-3-nitropyridine pictures 2026-08-20 2-Hydroxy-5-methyl-3-nitropyridine
7464-14-4
 $1.10 1g 99.00% 100 Tons Min Dideu Industries Group Limited
2-Hydroxy-5-methyl-3-nitropyridine pictures 2021-08-11 2-Hydroxy-5-methyl-3-nitropyridine
7464-14-4
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
2-Hydroxy-5-methyl-3-nitropyridine pictures 2020-05-26 2-Hydroxy-5-methyl-3-nitropyridine
7464-14-4
 1KG 99.0% 500 MT Shaanxi Dideu Medichem Co. Ltd

2-Hydroxy-5-methyl-3-nitropyridine Spectrum

2-Hydroxy-5-methyl-3-nitropyridine(7464-14-4)1HNMR2-Hydroxy-5-methyl-3-nitropyridine(7464-14-4)IR

7464-14-4 (2-Hydroxy-5-methyl-3-nitropyridine) Related Search:

2,4,6-Collidine Tribenuron methyl 2-Hydroxy-5-nitropyridine 3-Nitro-2-pyridinol Methylparaben
Methyl salicylate Methyl acrylate Methanol 2-Methyl-3-nitropyridine Basic Violet 1
4-Methylpyridine 2-Hydroxy-5-methylpyridine 2,6-Lutidine Methyl propyl carbonate Kresoxim-methyl
4-Hydroxy-3-nitropyridine Chlorophosphonazo III Metsulfuron methyl

1of4

2-HYDROXY-5-METHYL-3-NITROPYRIDINE 2-HYDROXY-3-NITRO-5-METHYLPYRIDINE 2-HYDROXY-3-NITRO-5-PICOLINE 5-METHYL-3-NITRO-2(1H)-PYRIDINONE 3-(NITRO)-5-METHYLPYRIDIN-2-OL 5-Methyl-3-nitropyridin-2-ol 2-HYDROXY-3-NITRO-5-PICOLINE (2-HYDROXY-5-METHYL-3-NITROPYRIDINE) 2-Hydroxy-5-methyl-3-nitropyridine 98% 5-Methyl-3-nitropyridin-2(1H)-one 5-Methyl-3-nitro-2(1H)-pyridone 5-Methyl-3-nitro-2-pyridinol 6-Hydroxy-5-nitro-3-picoline 2-Hydroxy-5-methyl-3-nitropyridine ISO 9001：2015 REACH 2(1H)-Pyridinone, 5-methyl-3-nitro- 7464-14-4 Heterocyclic Building Blocks Pyridines Building Blocks C6 Heterocyclic Building Blocks blocks NitroCompounds Pyridines Pyridine compounds of pyridine C6