Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>5-Pyrimidinecarboxamide, 2-[(2-aminoethyl)amino]-4-[[3-(trifluoromethyl)phenyl]amino]-, hydrochloride, hydrate (1:2:2)

5-Pyrimidinecarboxamide, 2-[(2-aminoethyl)amino]-4-[[3-(trifluoromethyl)phenyl]amino]-, hydrochloride, hydrate (1:2:2)

5-Pyrimidinecarboxamide, 2-[(2-aminoethyl)amino]-4-[[3-(trifluoromethyl)phenyl]amino]-, hydrochloride, hydrate (1:2:2) Structure
5-Pyrimidinecarboxamide, 2-[(2-aminoethyl)amino]-4-[[3-(trifluoromethyl)phenyl]amino]-, hydrochloride, hydrate (1:2:2) structure
CAS No.
1965323-05-0
Chemical Name:
5-Pyrimidinecarboxamide, 2-[(2-aminoethyl)amino]-4-[[3-(trifluoromethyl)phenyl]amino]-, hydrochloride, hydrate (1:2:2)
Synonyms
Syk Inhibitor II dihydrochloride dihydrate;5-Pyrimidinecarboxamide, 2-[(2-aminoethyl)amino]-4-[[3-(trifluoromethyl)phenyl]amino]-, hydrochloride, hydrate (1:2:2)
CBNumber:
CB012127540
Molecular Formula:
C14H18ClF3N6O2
Molecular Weight:
394.78
MDL Number:
MOL File:
1965323-05-0.mol
MSDS File:
SDS
Last updated:2026-04-21 10:31:43
Request For Quotation

5-Pyrimidinecarboxamide, 2-[(2-aminoethyl)amino]-4-[[3-(trifluoromethyl)phenyl]amino]-, hydrochloride, hydrate (1:2:2) Chemical Properties, Uses, Production

Uses

Syk Inhibitor II dihydrochloride dihydrate is a potent, high selective and ATP-competitive Syk inhibitor with an IC50 of 41 nM. Syk Inhibitor II dihydrochloride dihydrate inhibits 5-HT release from RBL-cells with an IC50 of 460 nM. Syk Inhibitor II dihydrochloride dihydrate shows less potent against other kinases and has anti-allergic effect[1].

in vivo

Syk Inhibitor II (Compound 9a; 10-100 mg/kg) dihydrochloride dihydrate is subcutaneously administered to mice 30 min before antigen challenge. Syk Inhibitor II inhibits the anaphylaxis reaction dose-dependently with an ID50 value of 13.2 mg/kg[1].

IC 50

Syk: 41 nM (IC50); serotonin: 460 nM (IC50); PKCε: 5.1 μM (IC50); PKCβ2: 11 μM (IC50); ZAP-70: 11.2 μM (IC50); Btk: 15.5 μM (IC50); Itk: 22.6 μM (IC50)

References

[1] Hiroyuki Hisamichi, et al. Synthetic studies on novel Syk inhibitors. Part 1: Synthesis and structure-activity relationships of pyrimidine-5-carboxamide derivatives. Bioorg Med Chem. 2005 Aug 15;13(16):4936-51. DOI:10.1016/j.bmc.2005.05.033

5-Pyrimidinecarboxamide, 2-[(2-aminoethyl)amino]-4-[[3-(trifluoromethyl)phenyl]amino]-, hydrochloride, hydrate (1:2:2) Preparation Products And Raw materials

Raw materials

Preparation Products

5-Pyrimidinecarboxamide, 2-[(2-aminoethyl)amino]-4-[[3-(trifluoromethyl)phenyl]amino]-, hydrochloride, hydrate (1:2:2) Suppliers

Global Suppliers ( 3)
Supplier Tel Email Country ProdList Advantage
Shandong Dayou Pharmaceutical Research and Development Co., Ltd. hanfangpharma@126.com 15165037910 hanfangpharma@126.com China 25800 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
TargetMol Chemicals Inc. 13564774135 marketing@targetmol.com United States 19950 58
Supplier Advantage
Shandong Dayou Pharmaceutical Research and Development Co., Ltd. 58
TargetMol Chemicals Inc. 58
TargetMol Chemicals Inc. 58

View Latest Price from 5-Pyrimidinecarboxamide, 2-[(2-aminoethyl)amino]-4-[[3-(trifluoromethyl)phenyl]amino]-, hydrochloride, hydrate (1:2:2) manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Syk Inhibitor II dihydrochloride dihydrate pictures 2026-04-21 Syk Inhibitor II dihydrochloride dihydrate
1965323-05-0
 $1520.00-2500.00 10g TargetMol Chemicals Inc.

1965323-05-0 (5-Pyrimidinecarboxamide, 2-[(2-aminoethyl)amino]-4-[[3-(trifluoromethyl)phenyl]amino]-, hydrochloride, hydrate (1:2:2)) Related Search:

5-Hydroxytryptophan 3-(2,4-dimethoxybenzylidene)anabaseine Puerarin DL-4-Chlorophenylalanine methyl ester hydrochloride VILAZODONE
Dihydroergotamine mesylate

1of2

5-Pyrimidinecarboxamide, 2-[(2-aminoethyl)amino]-4-[[3-(trifluoromethyl)phenyl]amino]-, hydrochloride, hydrate (1:2:2) Syk Inhibitor II dihydrochloride dihydrate 1965323-05-0 C14H18ClF3N6O2