ChemicalBook >> CAS DataBase List >>D-Leucine, D-asparaginyl-L-α-aspartyl-L-α-glutamyl-L-cysteinyl-L-α-glutamyl-L-leucyl-L-cysteinyl-L-valyl-L-asparaginyl-L-valyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-, cyclic (4→12),(7→15)-bis(disulfide)

D-Leucine, D-asparaginyl-L-α-aspartyl-L-α-glutamyl-L-cysteinyl-L-α-glutamyl-L-leucyl-L-cysteinyl-L-valyl-L-asparaginyl-L-valyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-, cyclic (4→12),(7→15)-bis(disulfide)

D-Leucine, D-asparaginyl-L-α-aspartyl-L-α-glutamyl-L-cysteinyl-L-α-glutamyl-L-leucyl-L-cysteinyl-L-valyl-L-asparaginyl-L-valyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-, cyclic (4→12),(7→15)-bis(disulfide) structure

CAS No.: 1092457-65-2

Chemical Name:: D-Leucine, D-asparaginyl-L-α-aspartyl-L-α-glutamyl-L-cysteinyl-L-α-glutamyl-L-leucyl-L-cysteinyl-L-valyl-L-asparaginyl-L-valyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-, cyclic (4→12),(7→15)-bis(disulfide)

Synonyms: Dolcanatide;D-Leucine, D-asparaginyl-L-α-aspartyl-L-α-glutamyl-L-cysteinyl-L-α-glutamyl-L-leucyl-L-cysteinyl-L-valyl-L-asparaginyl-L-valyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-, cyclic (4→12),(7→15)-bis(disulfide)

CBNumber:: CB012763472

Molecular Formula:: C65H104N18O26S4

Molecular Weight:: 1681.89

MDL Number:

MOL File:: 1092457-65-2.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-24 14:58:35

Request For Quotation

D-Leucine, D-asparaginyl-L-α-aspartyl-L-α-glutamyl-L-cysteinyl-L-α-glutamyl-L-leucyl-L-cysteinyl-L-valyl-L-asparaginyl-L-valyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-, cyclic (4→12),(7→15)-bis(disulfide) Properties

Boiling point	2120.0±65.0 °C(Predicted)
Density	1.47±0.1 g/cm3(Predicted)
pka	3.61±0.21(Predicted)
form	Solid
color	White to off-white
Sequence	{d-Asn}--Asp-Glu-Cys-Glu-Leu-Cys-Val-Asn-Val-Ala-Cys-Thr-Gly-Cys-{d-Leu} (Disulfide bridge: Cys4-Cys12; Cys7-Cys15)
FDA UNII	WU977T914K

D-Leucine, D-asparaginyl-L-α-aspartyl-L-α-glutamyl-L-cysteinyl-L-α-glutamyl-L-leucyl-L-cysteinyl-L-valyl-L-asparaginyl-L-valyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-, cyclic (4→12),(7→15)-bis(disulfide) price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-0615000	Dolcanatide 99.20%	1092457-65-2	1mg	$238	2026-06-04	Buy
ChemScene	CS-0615000	Dolcanatide 99.20%	1092457-65-2	5mg	$596	2026-06-04	Buy
aablocks	AA01X6GD	Dolcanatide >98%	1092457-65-2	1mg	$280	2026-06-01	Buy
aablocks	AA01X6GD	Dolcanatide >98%	1092457-65-2	5mg	$647	2026-06-01	Buy

Product number	Packaging	Price	Buy
CS-0615000	1mg	$238	Buy
CS-0615000	5mg	$596	Buy
AA01X6GD	1mg	$280	Buy
AA01X6GD	5mg	$647	Buy

D-Leucine, D-asparaginyl-L-α-aspartyl-L-α-glutamyl-L-cysteinyl-L-α-glutamyl-L-leucyl-L-cysteinyl-L-valyl-L-asparaginyl-L-valyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-, cyclic (4→12),(7→15)-bis(disulfide) Chemical Properties, Uses, Production

Uses

Dolcanatide is an orally active GC-C (guanylate cyclase-C) agonist. Dolcanatide shows laxative, anti-nociceptive and anti-inflammatory activity. Dolcanatide can be used in inflammatory bowel disease research[1][2].

in vivo

Dolcanatide (oral administration; 0.01 and 0.05 mg/kg; once) alleviates TNBS-induced rectal allodynia in rats^[1].
Dolcanatide (oral administration; 0.01 and 0.05 mg/kg; once) alleviates stress-induced colorectal hypersensitivity (CRD) in rats^[1].

Animal Model:	TNBS-induced rectal allodynia in rats^[1]
Dosage:	0.01 and 0.05 mg/kg
Administration:	Oral administration; 0.01 and 0.05 mg/kg; once
Result:	Attenuated the TNBS-induced increase in the number of abdominal contractions (distending pressures up to 60 mmHg).

Animal Model:	Stress-induced visceral hypersensitivity in Wistar rats^[1]
Dosage:	0.01 and 0.05 mg/kg
Administration:	Oral administration; 0.01 and 0.05 mg/kg; once
Result:	Resulted in a significant reduction in the rate of PRS (partial restraint stress)-induced abdominal contractions with increasing CRD (colorectal distension) pressures.

References

[1] Boulete IM, et al. Oral treatment with plecanatide or dolcanatide attenuates visceral hypersensitivity via activation of guanylate cyclase-C in rat models. World J Gastroenterol. 2018 May 7;24(17):1888-1900. DOI:10.3748/wjg.v24.i17.1888
[2] Shailubhai K, et al. Plecanatide and dolcanatide, novel guanylate cyclase-C agonists, ameliorate gastrointestinal inflammation in experimental models of murine colitis. World J Gastrointest Pharmacol Ther. 2015 Nov 6;6(4):213-22. DOI:10.4292/wjgpt.v6.i4.213

D-Leucine, D-asparaginyl-L-α-aspartyl-L-α-glutamyl-L-cysteinyl-L-α-glutamyl-L-leucyl-L-cysteinyl-L-valyl-L-asparaginyl-L-valyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-, cyclic (4→12),(7→15)-bis(disulfide) Preparation Products And Raw materials

Raw materials

Preparation Products

D-Leucine, D-asparaginyl-L-α-aspartyl-L-α-glutamyl-L-cysteinyl-L-α-glutamyl-L-leucyl-L-cysteinyl-L-valyl-L-asparaginyl-L-valyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-, cyclic (4→12),(7→15)-bis(disulfide) Suppliers

Global Suppliers ( 5)

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai YuanYe Biotechnology Co., Ltd.	15026964105	2881489226@qq.com	China	89667	60
Hangzhou Peptidego Biotech Co.,Ltd.	0571-87213919 15967184799	Eric@peptidego.com	China	7872	58
Nanchang Tianzhen Biotechnology Co., Ltd	13758194781 13173652190	522013271@qq.com	China	2447	58
Hangzhou Sinoda Pharmaceutical Technology Co. LTD	0571-87213919 17306812703	3007955328@qq.com	China	7446	58

Supplier	Advantage
Shanghai YuanYe Biotechnology Co., Ltd.	60
Hangzhou Peptidego Biotech Co.,Ltd.	58
Nanchang Tianzhen Biotechnology Co., Ltd	58
Hangzhou Sinoda Pharmaceutical Technology Co. LTD	58

1092457-65-2 (D-Leucine, D-asparaginyl-L-α-aspartyl-L-α-glutamyl-L-cysteinyl-L-α-glutamyl-L-leucyl-L-cysteinyl-L-valyl-L-asparaginyl-L-valyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-, cyclic (4→12),(7→15)-bis(disulfide)) Related Search:

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