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ChemicalBook >> CAS DataBase List >>4-[N-(4-Carboxybutyl)-N-[2-[2-[4-(2-phenylethyl)benzyloxy]phenyl]ethyl]aMinoMethyl]benzoic acid

4-[N-(4-Carboxybutyl)-N-[2-[2-[4-(2-phenylethyl)benzyloxy]phenyl]ethyl]aMinoMethyl]benzoic acid

4-[N-(4-Carboxybutyl)-N-[2-[2-[4-(2-phenylethyl)benzyloxy]phenyl]ethyl]aMinoMethyl]benzoic acid Structure
4-[N-(4-Carboxybutyl)-N-[2-[2-[4-(2-phenylethyl)benzyloxy]phenyl]ethyl]aMinoMethyl]benzoic acid structure
CAS No.
329773-35-5
Chemical Name:
4-[N-(4-Carboxybutyl)-N-[2-[2-[4-(2-phenylethyl)benzyloxy]phenyl]ethyl]aMinoMethyl]benzoic acid
Synonyms
Cinaciguat;CS-778;BAY 58-2667;Cinaciguat BAY-58-2667;Cinaciguat, 10 mM in DMSO;Cinaciguat,Inhibitor,inhibit,Guanylate Cyclase;4-(((4-Carboxybutyl)(2-((4-phenethylbenzyl)oxy)phenethyl)amino)methyl)benzoic acid;4-[N-(4-Carboxybutyl)-N-[2-[2-[4-(2-phenylethyl)benzyloxy]phenyl]ethyl]aMinoMethyl]benzoic acid;4-[[(4-Carboxybutyl)[2-[2-[[4-(2-phenylethyl)phenyl]methoxy]phenyl]ethyl]amino]methyl]-benzoic acid;Benzoic acid, 4-[[(4-carboxybutyl)[2-[2-[[4-(2-phenylethyl)phenyl]methoxy]phenyl]ethyl]amino]methyl]-
CBNumber:
CB12563263
Molecular Formula:
C36H39NO5
Molecular Weight:
565.7
MDL Number:
MFCD18782678
MOL File:
329773-35-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-17 09:03:53
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4-[N-(4-Carboxybutyl)-N-[2-[2-[4-(2-phenylethyl)benzyloxy]phenyl]ethyl]aMinoMethyl]benzoic acid Properties

storage temp. Inert atmosphere,Store in freezer, under -20°C
solubility Soluble in DMSO
form Powder
color White to off-white
FDA UNII 59K0Y58UAD

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

4-[N-(4-Carboxybutyl)-N-[2-[2-[4-(2-phenylethyl)benzyloxy]phenyl]ethyl]aMinoMethyl]benzoic acid price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth ENA77335 Cinaciguat 329773-35-5 10mg $896.6 2026-06-04 Buy
Biosynth ENA77335 Cinaciguat 329773-35-5 25mg $1462 2026-06-04 Buy
Biosynth ENA77335 Cinaciguat 329773-35-5 50mg $2339 2026-06-04 Buy
ChemScene CS-1169 Cinaciguat 99.15% 329773-35-5 2mg $130 2026-06-04 Buy
ChemScene CS-1169 Cinaciguat 99.15% 329773-35-5 5mg $195 2026-06-04 Buy
Product number Packaging Price Buy
ENA77335 10mg $896.6 Buy
ENA77335 25mg $1462 Buy
ENA77335 50mg $2339 Buy
CS-1169 2mg $130 Buy
CS-1169 5mg $195 Buy

4-[N-(4-Carboxybutyl)-N-[2-[2-[4-(2-phenylethyl)benzyloxy]phenyl]ethyl]aMinoMethyl]benzoic acid Chemical Properties, Uses, Production

Definition

ChEBI: Cinaciguat is a benzoic acid that is 4-(aminomethyl)benzoic acid in which the amino group is substituted by 4-carboxybutyl and 2-(2-{[4-(2-phenylethyl)benzyl]oxy}phenyl)ethyl groups. It is a soluble guanylate cyclase activator, used for the treatment of acute decompensated heart failure. It has a role as a vasodilator agent, a soluble guanylate cyclase activator and an antihypertensive agent. It is a member of benzoic acids, a tertiary amino compound, an aromatic ether and a dicarboxylic acid.

Biological Activity

Cinaciguat hydrochloride is a nitric oxide-independent guanylate cyclase (GC) activator with a Kd of 3.2 nM.

in vitro

Cinaciguat (10 μM) significantly enhances intracellular cGMP generation. It does not dose-dependent effects on cell contraction and calcium transients.

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in vivo

Cinaciguat (10 mg/kg/day, po) treatment in diabetic rats does not influence blood glucose levels, but leads to attenuated water intake. It treatment alleviates diabetes mellitus related oxidative stress, protects against DM related alteration of the NO-sGC-cGMP-PKG signalling, and alleviates DM related myocardium hypertrophy and apoptosis. Cinaciguat (1-10-100 nM) induces concentration-dependent relaxations in strips from both WT and apo-sGC mice, but does not have any effect on phasic activity induced by PGF 2α in WT or apo-sGC strips.

target

sGC

4-[N-(4-Carboxybutyl)-N-[2-[2-[4-(2-phenylethyl)benzyloxy]phenyl]ethyl]aMinoMethyl]benzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

4-[N-(4-Carboxybutyl)-N-[2-[2-[4-(2-phenylethyl)benzyloxy]phenyl]ethyl]aMinoMethyl]benzoic acid Suppliers

Global Suppliers ( 89)
Supplier Tel Email Country ProdList Advantage
Shanghai Fuhe Chemistry Technology Co., Ltd. 0086-21-67651709 cfx759@hotmail.com China 409 57
Shanghai T&W Pharmaceutical Co., Ltd. +86 21 61551611 China 9874 58
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7545 61
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4853 58
Nanjing Dulai Biotechnology Co., Ltd. 025-84699383-8003;025-846993838003-8003 18013301590 njduly@126.com China 3293 55
CEG Chemical Science&Technology Co., Ltd. Mobile:13665161512 China 1784 58
LETOPHARM LIMITED +86-21-5821 5861 sales@letopharm.com China 2374 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4860 55
AN PharmaTech Co Ltd 86(21)68097365 sales@anpharma.net China 4875 55
Guangzhou QiYun Biotechnology Co., Ltd. 020-61288194 61288195 505721671@qq.com China 3853 58
Supplier Advantage
Shanghai Fuhe Chemistry Technology Co., Ltd. 57
Shanghai T&W Pharmaceutical Co., Ltd. 58
Haoyuan Chemexpress Co., Ltd. 61
MedChemexpress LLC 58
Nanjing Dulai Biotechnology Co., Ltd. 55
CEG Chemical Science&Technology Co., Ltd. 58
LETOPHARM LIMITED 58
Shanghai Lollane Biological Technology Co.,Ltd. 55
AN PharmaTech Co Ltd 55
Guangzhou QiYun Biotechnology Co., Ltd. 58

View Latest Price from 4-[N-(4-Carboxybutyl)-N-[2-[2-[4-(2-phenylethyl)benzyloxy]phenyl]ethyl]aMinoMethyl]benzoic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Cinaciguat pictures 2026-07-17 Cinaciguat
329773-35-5
 $40.00-148.00 99.18% 10g TargetMol Chemicals Inc.
4-[N-(4-Carboxybutyl)-N-[2-[2-[4-(2-phenylethyl)benzyloxy]phenyl]ethyl]aMinoMethyl]benzoic acid pictures 2020-02-21 4-[N-(4-Carboxybutyl)-N-[2-[2-[4-(2-phenylethyl)benzyloxy]phenyl]ethyl]aMinoMethyl]benzoic acid
329773-35-5
 $3.00 1KG 98% 200KG Career Henan Chemical Co
  • Cinaciguat pictures
  • Cinaciguat
    329773-35-5
  • $40.00-148.00
  • 99.18%
  • TargetMol Chemicals Inc.

4-[N-(4-Carboxybutyl)-N-[2-[2-[4-(2-phenylethyl)benzyloxy]phenyl]ethyl]aMinoMethyl]benzoic acid Spectrum

4-[N-(4-Carboxybutyl)-N-[2-[2-[4-(2-phenylethyl)benzyloxy]phenyl]ethyl]aMinoMethyl]benzoic acid(329773-35-5)1HNMR

329773-35-5 (4-[N-(4-Carboxybutyl)-N-[2-[2-[4-(2-phenylethyl)benzyloxy]phenyl]ethyl]aMinoMethyl]benzoic acid) Related Search:

4-Ethoxy-3-pyrrolidin-1-ylmethyl-benzoic acidhydrochloride 4-[N-(4-Carboxybutyl)-N-[2-[2-[4-(2-phenylethyl)benzyloxy]phenyl]ethyl]aMinoMethyl]benzoic acid BAY 58-2667 hydrochloride 3-(Benzylamino)-4-[4-(benzyloxy)phenyl]butanoic Acid D-Leucine, D-asparaginyl-L-α-aspartyl-L-α-glutamyl-L-cysteinyl-L-α-glutamyl-L-leucyl-L-cysteinyl-L-valyl-L-asparaginyl-L-valyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-, cyclic (4→12),(7→15)-bis(disulfide)
NS-2028

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4-[N-(4-Carboxybutyl)-N-[2-[2-[4-(2-phenylethyl)benzyloxy]phenyl]ethyl]aMinoMethyl]benzoic acid BAY 58-2667 4-[[(4-Carboxybutyl)[2-[2-[[4-(2-phenylethyl)phenyl]methoxy]phenyl]ethyl]amino]methyl]-benzoic acid Cinaciguat BAY-58-2667 CS-778 Benzoic acid, 4-[[(4-carboxybutyl)[2-[2-[[4-(2-phenylethyl)phenyl]methoxy]phenyl]ethyl]amino]methyl]- 4-(((4-Carboxybutyl)(2-((4-phenethylbenzyl)oxy)phenethyl)amino)methyl)benzoic acid Cinaciguat,Inhibitor,inhibit,Guanylate Cyclase Cinaciguat, 10 mM in DMSO Cinaciguat 329773-35-5 C36H39NO5 Inhibitors