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CYCLO(-PRO-VAL)

CYCLO(-PRO-VAL) structure

CAS No.: 2854-40-2

Chemical Name:: CYCLO(-PRO-VAL)

Synonyms: CYCLO(L-PROLYL-L-VALINE);Cyclo(L-prolyl-L-valyl);c(Pro-Val);Cyclo(Val-Pro);CYCLO(-PRO-VAL);Cyclo(L-Val-L-Pro-);Cyclo(L-Pro-L-Val-);2854-40-2/5654-87-5;Vildagliptin Impurity 114;Cyclo(L-Pro-L-Val),CYCLO(-PRO-VAL)

CBNumber:: CB0132749

Molecular Formula:: C10H16N2O2

Molecular Weight:: 196.25

MDL Number:: MFCD03093469

MOL File:: 2854-40-2.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-27 17:00:41

Product description	Number	Pack Size	Price
Cyclo(L-Pro-L-Val) min. 95.0 %	C3893	25MG	$66
Cyclo(L-Pro-L-Val) ≥95%	27961	25mg	$41
Cyclo(L-Pro-L-Val) ≥95%	27961	50mg	$75
Cyclo(L-Pro-L-Val) ≥95%	27961	100mg	$142
Cyclo(L-Pro-L-Val) ≥95%	27961	250mg	$312

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CYCLO(-PRO-VAL) Properties

Melting point	190-192 °C
Boiling point	420.7±34.0 °C(Predicted)
Density	1.17±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform (Slightly, Sonicated), Methanol (Slightly)
form	Solid
pka	13.15±0.40(Predicted)
color	White to Off-White
Sequence	Cyclo(Pro-Val)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338

CYCLO(-PRO-VAL) price More Price(63)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	C3893	Cyclo(L-Pro-L-Val) min. 95.0 %	2854-40-2	25MG	$66	2026-04-30	Buy
Cayman Chemical	27961	Cyclo(L-Pro-L-Val) ≥95%	2854-40-2	25mg	$41	2026-04-30	Buy
Cayman Chemical	27961	Cyclo(L-Pro-L-Val) ≥95%	2854-40-2	50mg	$75	2026-04-30	Buy
Cayman Chemical	27961	Cyclo(L-Pro-L-Val) ≥95%	2854-40-2	100mg	$142	2026-04-30	Buy
Cayman Chemical	27961	Cyclo(L-Pro-L-Val) ≥95%	2854-40-2	250mg	$312	2026-04-30	Buy

Product number	Packaging	Price	Buy
C3893	25MG	$66	Buy
27961	25mg	$41	Buy
27961	50mg	$75	Buy
27961	100mg	$142	Buy
27961	250mg	$312	Buy

CYCLO(-PRO-VAL) Chemical Properties,Uses,Production

Description

Cyclo(L-Pro-L-Val) is a diketopiperazine that has been found in the marine sponge T. ignis, the bacterium B. pumilus, and the fungus A. fumigatus, among others. It is active against the bacteria S. aureus and B. subtilis (MICs = 16.3 and 18.2 μg/ml, respectively) but not E. coli (MIC = >20 μg/ml). Cyclo(L-Pro-L-Val) inhibits activation of a LuxR-dependent E. coli biosensor by the quorum-sensing molecule 3-oxo-hexanoyl-homoserine lactone (IC₅₀ = 0.4 mM) and activates violacein pigment production in the LuxR-dependent C. violaceum acyl homoserine lactone reporter strain CV026. However, it does not activate or inhibit lacZ-based reporter fusions in S. liquefaciens or A. tumefaciens.

Uses

Cyclo(L-Pro-L-Val) is a diketopiperazine formed by the fusion of valine and proline, reported as a secondary metabolite of fungi and bacteria. In Pseudomonas aeruginosa, cyclo(L-Pro-L-Val) is capable of activating N-acylhomoserine lactones (AHLs). Cyclo(L-Pro-L-Val) is also capable of activating or antagonizing other LuxR-based quorum-sensing systems. While the mode of action of the cyclo(L-Pro-L-Val) is not known, its activity suggests the existence of cross talk among bacterial signalling systems.

Uses

Cyclo(L-prolyl-L-valyl) is a metabolite found in various marine fungi and bacteria. It is a diketopiperazine derivative isolated from Bacillus thuringiensis and Bacillus endophyticus.

Definition

ChEBI: Cyclo(L-Pro-L-Val) is a piperazinone. It has a role as a metabolite.

References

[1] FRANCIS J. SCHMIDTZ. Metabolites from the marine sponge Tedania ignis. A new atisanediol and several known diketopiperazines[J]. The Journal of Organic Chemistry, 1983, 48 22: 3941-3945. DOI: 10.1021/jo00170a011
[2] CHRISTIANE BRACK Frieder S Annett Mikolasch. 2,5-Diketopiperazines Produced by Bacillus pumilus During Bacteriolysis of Arthrobacter citreus[J]. Marine Biotechnology, 2014, 16 4: 385-395. DOI: 10.1007/s10126-014-9559-y
[3] BAHAA EL-DIEN M. EL-GENDY Mostafa E R. Antibacterial activity of diketopiperazines isolated from a marine fungus using t-butoxycarbonyl group as a simple tool for purification[J]. Bioorganic & Medicinal Chemistry Letters, 2015, 25 16: Pages 3125-3128. DOI: 10.1016/j.bmcl.2015.06.010
[4] M T HOLDEN. Quorum-sensing cross talk: isolation and chemical characterization of cyclic dipeptides from Pseudomonas aeruginosa and other gram-negative bacteria.[J]. Molecular Microbiology, 1999, 33 6: 1254-1266. DOI: 10.1046/j.1365-2958.1999.01577.x

CYCLO(-PRO-VAL) Preparation Products And Raw materials

Raw materials

Preparation Products

9-(2'-ACETOXYETHOXYMETHYL)-GUANINE

CYCLO(-PRO-VAL) Suppliers

Global( 101)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19936	58
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32466	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471	sales@sarms4muscle.com	China	10457	58
Nextpeptide Inc	+86-0571-81612335 +8613336028439	sales@nextpeptide.com	China	19908	58
Chengdu Youngshe Chemical Co., Ltd.	+86-18108235634	Cecilia@youngshechem.com	China	2345	58
HANGZHOU LEAP CHEM CO., LTD.	+86-571-87711850 +8619957148339	market18@leapchem.com	China	24597	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49734	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	39037	58
Changsha MOL Changes Biotechnology Co., Ltd.	+8619375158599	info@molchanges.com	China	5218	58
Shaanxi Dideu New Materials Co. Ltd	18192503167	1036@dideu.com	China	12484	58

Supplier	Advantage
BOC Sciences	58
TargetMol Chemicals Inc.	58
Zhejiang J&C Biological Technology Co.,Limited	58
Nextpeptide Inc	58
Chengdu Youngshe Chemical Co., Ltd.	58
HANGZHOU LEAP CHEM CO., LTD.	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	58
TargetMol Chemicals Inc.	58
Changsha MOL Changes Biotechnology Co., Ltd.	58
Shaanxi Dideu New Materials Co. Ltd	58

View Lastest Price from CYCLO(-PRO-VAL) manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-07-27	Cyclo(L-Pro-L-Val) 2854-40-2	$39.00-93.00		99.99%	10g	TargetMol Chemicals Inc.
2026-07-27	Cyclo(L-Pro-L-Val) 2854-40-2	$39.00-93.00		99.99%	10g	TargetMol Chemicals Inc.
2026-07-08	CYCLO(-PRO-VAL) 2854-40-2		1KG	98%	1000kg	Shaanxi Dideu New Materials Co. Ltd

Cyclo(L-Pro-L-Val)
2854-40-2
$39.00-93.00
99.99%
TargetMol Chemicals Inc.

Cyclo(L-Pro-L-Val)
2854-40-2
$39.00-93.00
99.99%
TargetMol Chemicals Inc.

CYCLO(-PRO-VAL)
2854-40-2
$0.00
98%
Shaanxi Dideu New Materials Co. Ltd

CYCLO(-PRO-VAL) Spectrum

CYCLO(-PRO-VAL)(2854-40-2)¹HNMR

2854-40-2(CYCLO(-PRO-VAL))Related Search:

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cyclo(Pro-Cys) (S)-3-Isopropyl-2,5-piperazinedione CYCLO(-PRO-VAL) 3-ISOPROPYL-PIPERAZIN-2-ONE (R)-HEXAHYDROPYRROLO[1,2-A]PYRAZIN-1(2H)-ONE

(3S)-3-ISOPROPYL-1-METHYLPIPERAZINE (2S)-ISOPROPYLPIPERAZINE

1of4

CYCLO(-PRO-VAL) (3S,8aS)-3-Isopropyl-6,7,8,8aα-tetrahydropyrrolo[1,2-a]pyrazine-1,4(2H,3H)-dione (3S,8aS)-3β-Isopropyl-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazine-1,4(2H,3H)-dione (3S,8aS)-Octahydro-3-(1-methylethyl)pyrrolo[1,2-a]pyrazine-1,4-dione (3S,8aα)-3β-Isopropyloctahydropyrrolo[1,2-a]pyrazine-1,4-dione Cyclo(L-Pro-L-Val-) Cyclo(L-Val-L-Pro-) Pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro-3-(1-methylethyl)-, (3S,8aS)- (3S,8aS)-3-propan-2-yl-2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione (3S,8aS)-3-(propan-2-yl)-octahydropyrrolo[1,2-a]p yrazine-1,4-dione (3S,8aS)-3-Isopropylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione Cyclo(L-Pro-L-Val),CYCLO(-PRO-VAL) 2854-40-2/5654-87-5 Cyclo(Val-Pro) c(Pro-Val) Vildagliptin Impurity 114 Cyclo(L-prolyl-L-valyl) CYCLO(L-PROLYL-L-VALINE) 2854-40-2