GR231118
- CAS No.
- 158859-98-4
- Chemical Name:
- GR231118
- Synonyms
- 1229U91;GR231118;NEUROPEPTIDE Y ANTAGONIST;M.W. 2352.77 C110H170N34O24;Amide Bridge=Glu2-Dap4*,Dap4-Glu2*;H-ILE-GLU-PRO-DAP-TYR-ARG-LEU-ARG-TYR-NH2;H-Ile-Glu-Pro-Dapa-Tyr-Arg-Leu-Arg-Tyr-NH2;ILE-GLU-PRO-DAPA-TYR-ARG-LEU-ARG-TYR-NH2, CYCLIC (2,4') (2',4) DIAMIDE;Ile-Glu-Pro-Dapa-Tyr-Arg-Leu-Arg-Tyr-NH2, cyclic (2,4') (2',4) diaMide (Dapa : diaMinopropionic acid);1229U91, Neuropeptide Y Antagonist, Ile-Glu-Pro-Dapa-Tyr-Arg-Leu-Arg-Tyr-NH2, cyclic (2,4μ)(2μ,4) diamide
- CBNumber:
- CB0142308
- Molecular Formula:
- C110H170N34O24
- Molecular Weight:
- 2352.74
- MDL Number:
- MFCD00927773
- MOL File:
- 158859-98-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
GR231118 price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 255396 | GR 231118 Asreported | 158859-98-4 | 500ug | $808 | 2026-06-03 | Buy |
| ApexBio Technology | B6760 | GR 231118 | 158859-98-4 | 500ug | $594 | 2026-05-06 | Buy |
| Tocris | 1486 | GR231118 | 158859-98-4 | 500U | $382 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | PEP0001648 | GR231118 95.00% | 158859-98-4 | 0.5MG | $710.33 | 2021-12-16 | Buy |
GR231118 Chemical Properties, Uses, Production
Uses
GR231118, an analogue of the C-terminus of neuropeptide Y, is a potent , competitive and relative seletive antagonist at human neuropeptide Y Y receptor with a pKi of 10.4. GR231118 a potent agonist at the human neuropeptide Y Y4 receptor (pEC50=8.6; pKi=9.6) and a weak agonist at the human and rat neuropeptide YY2 and Y5 receptors. GR231118 also has high affinity for the mouse neuropeptide Y Y6 receptor (pKi= 8.8)[1].
IC 50
NPY Y4 receptor
References
[1] E M Parker, et al. GR231118 (1229U91) and other analogues of the C-terminus of neuropeptide Y are potent neuropeptide Y Y1 receptor antagonists and neuropeptide Y Y4 receptor agonists. Eur J Pharmacol DOI:10.1016/s0014-2999(98)00171-x
[2] Y Dumont, et al. [(125)I]-GR231118: a high affinity radioligand to investigate neuropeptide Y Y(1) and Y(4) receptors. Br J Pharmacol.2000 Jan;129(1):37-46. DOI:10.1038/sj.bjp.0702983
GR231118 Preparation Products And Raw materials
Raw materials
Preparation Products
GR231118 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| GL Biochem (Shanghai) Ltd | 21-61263452 13641803416 | ymbetter@glbiochem.com | China | 9981 | 64 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Creative Peptides | info@creative-peptides.com | United States | 6083 | 56 | |
| Chengdu Youngshe Chemical Co., Ltd. | +86-17380623303 | Caroline@youngshechem.com | China | 4725 | 58 |
| Hangzhou Peptidego Biotech Co.,Ltd. | 0571-87213919 15967184799 | Eric@peptidego.com | China | 7872 | 58 |
| Nanjing Meihao Pharmaceutical Technology Co., Ltd. | meitaochem@126.com | meitaochem@126.com | China | 19087 | 58 |
| Alfa Chemistry | +1-5166625404; | Info@alfa-chemistry.com | United States | 20000 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +86-13203830695 | laboratory@coreychem.com | China | 30203 | 58 |
