6-(4-Methylphenyl)-picolinic acid
- CAS No.
- 86696-72-2
- Chemical Name:
- 6-(4-Methylphenyl)-picolinic acid
- Synonyms
- 6-(p-Tolyl)picolinic acid;6-(4-Methylphenyl)-picolinic acid;6-(4-Methylphenyl)-2-pyridinecarboxylic Acid;2-Pyridinecarboxylic acid, 6-(4-methylphenyl)-
- CBNumber:
- CB01455667
- Molecular Formula:
- C13H11NO2
- Molecular Weight:
- 213.23
- MDL Number:
- MFCD06410065
- MOL File:
- 86696-72-2.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
6-(4-Methylphenyl)-picolinic acid price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 082400 | 6-(4-Methylphenyl)pyridine-2-carboxylic acid | 86696-72-2 | 1.00g | $488 | 2026-05-18 | Buy |
| aablocks | AA004O3H | 6-(4-Methylphenyl)picolinic acid 97% | 86696-72-2 | 250mg | $96 | 2026-05-28 | Buy |
| aablocks | AA004O3H | 6-(4-Methylphenyl)picolinic acid 97% | 86696-72-2 | 1g | $229 | 2026-05-28 | Buy |
| aablocks | AA004O3H | 6-(4-Methylphenyl)picolinic acid 97% | 86696-72-2 | 5g | $674 | 2026-05-28 | Buy |
| aablocks | AA004O3H | 6-(4-Methylphenyl)picolinic acid 97% | 86696-72-2 | 10g | $1007 | 2026-05-28 | Buy |
6-(4-Methylphenyl)-picolinic acid Chemical Properties, Uses, Production
Synthesis
21190-87-4
5720-05-8
86696-72-2
Suzuki coupling reaction was carried out in Biotage Smith Synthesizer using 6-bromo-2-pyridine carboxylic acid (202 mg, 1 mmol) and 4-tolylboronic acid (163 mg, 1.2 mmol). The reactants were mixed with Pd(PPh3)4 (25 mg) catalyst, saturated aqueous NaHCO3 solution (3 mL) and DME (3 mL) and reacted in a microwave reactor for 2 hours at 100 °C. The reaction progress was monitored by TLC, and after confirming the completion of the reaction, the reaction mixture was filtered and washed sequentially with water (2 × 50 mL) and ether (2 × 50 mL). After separating the organic and aqueous layers, the pH of the aqueous layer was adjusted with 1N HCl aqueous solution to about 1. Subsequently, the aqueous layer was extracted with ethyl acetate (3 × 60 mL). The organic layers were combined, dried with anhydrous sodium sulfate and filtered. Finally, the target product 6-(4-methylphenyl)-2-pyridinecarboxylic acid (191 mg, 90% yield) was obtained by evaporating the solvent.
References
[1] Patent: WO2011/94890, 2011, A1. Location in patent: Page/Page column 122
[2] Patent: US2012/4198, 2012, A1. Location in patent: Page/Page column 33-34
6-(4-Methylphenyl)-picolinic acid Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
6-(4-Methylphenyl)-picolinic acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ShangHai AmK Pharmaceutical Technology Co., Ltd. | 微信 18019252918 18019252918 | sale@amkchem.com | China | 14982 | 55 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Amatek Scientific Co. Ltd. | 0512-56316828 400-867-5858;400-867-5858 | info@amateksci.com | China | 28760 | 58 |
| Changzhou Kechem Bio-Scientific Co., LTD. | 0519-68985668 13685222090 | sales@kechem.cn | China | 26012 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44871 | 58 |
| Henan Dowon Chemical Technology Co., Ltd. | 16696119288 | 779113375@qq.com | China | 7401 | 58 |
