4-Tolylboronic acid
- CAS No.
- 5720-05-8
- Chemical Name:
- 4-Tolylboronic acid
- Synonyms
- P-TOLYLBORONIC ACID;4-METHYLPHENYLBORONIC ACID;p-Tolueneboronic acid;t-509;NSC 62870;AKOS BRN-0019;p-tolyl-boronicaci;4-TOLYBORONIC ACID;RARECHEM AH PB 0227;4-TOLYLBORONIC ACID
- CBNumber:
- CB0702562
- Molecular Formula:
- C7H9BO2
- Molecular Weight:
- 135.96
- MDL Number:
- MFCD00039138
- MOL File:
- 5720-05-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 256-263 °C(lit.) |
|---|---|
| Boiling point | 275.2±33.0 °C(Predicted) |
| Density | 1.10±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 8.84±0.10(Predicted) |
| form | Crystalline Powder |
| color | Off-white |
| Water Solubility | It is soluble in water. |
| BRN | 2935970 |
| InChI | InChI=1S/C7H9BO2/c1-6-2-4-7(5-3-6)8(9)10/h2-5,9-10H,1H3 |
| InChIKey | BIWQNIMLAISTBV-UHFFFAOYSA-N |
| SMILES | B(C1=CC=C(C)C=C1)(O)O |
| CAS DataBase Reference | 5720-05-8(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | YJM4GM7K66 |
| NIST Chemistry Reference | P-methylbenzeneboronic acid(5720-05-8) |
| UNSPSC Code | 12352103 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | XS7400000 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29319090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
4-Tolylboronic acid price More Price(89)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 393622 | p-Tolylboronic acid 97% | 5720-05-8 | 1g | $49.1 | 2026-04-30 | Buy |
| Sigma-Aldrich | 393622 | p-Tolylboronic acid 97% | 5720-05-8 | 10g | $274 | 2026-04-30 | Buy |
| TCI Chemical | M1126 | 4-Methylphenylboronic Acid (contains varying amounts of Anhydride) | 5720-05-8 | 5g | $43 | 2026-04-30 | Buy |
| TCI Chemical | M1126 | 4-Methylphenylboronic Acid (contains varying amounts of Anhydride) | 5720-05-8 | 25g | $140 | 2026-04-30 | Buy |
| Strem Chemicals | 05-1051 | p-Tolylboronic acid, min. 97% min.97% | 5720-05-8 | 5g | $118 | 2026-04-30 | Buy |
4-Tolylboronic acid Chemical Properties, Uses, Production
Synthesis
In a 250ml double-necked flask, add treated Mg strips (2.15g, 90mmol), 2 iodine grains, and under nitrogen protection, evacuate three times. Under heating conditions, slowly add anhydrous THF solution of compound p-methylbromobenzene (compound 1, 60mmol) using a syringe. After the reaction is initiated, reflux is maintained, and the remaining solution is added. After the addition is complete, the reaction is refluxed for 5 hours to obtain Grignard reagent for p-bromotoluene (compound 2). After cooling to room temperature, the reaction apparatus is transferred to a low-temperature reactor, and the temperature is adjusted to -20℃. After 5 minutes, anhydrous THF solution of trimethyl borate (9.36g, 90mmol) is added using a syringe. After the addition is complete, the reaction is carried out at room temperature for 3 hours. Then, 100ml of 2mol/L HCl solution is added to initiate the hydrolysis reaction, and the reaction is detected by TLC. After the reaction was complete, THF was removed by rotary evaporation under reduced pressure. The aqueous phase was extracted three times with ethyl acetate. The extracted organic phases were combined and washed with water and saturated brine until neutral. The mixture was then dried over anhydrous sodium sulfate, filtered, and the solvent was removed by rotary evaporation under reduced pressure. Recrystallization from anhydrous ethanol yielded 4.66 g of 4-Tolylboronic acid (compound 3), with a yield of 57%.
Chemical Properties
white to light yellow crystal powder
Uses
suzuki reaction
Uses
4-Methylbenzeneboronic acid, is a commonly used chemical in Suzuki coupling reactions. It is also used as an intermediate in pharmaceutical industry
Uses
Reagent used for
- Palladium (Pd)-catalyzed direct arylation
- Direct Palladium(II)-Catalyzed Synthesis
- Palladium-catalyzed arylation by Suzuki-Miyaura cross-coupling in water
- Cyclopalladation
- Tandem-type Pd(II)-catalyzed oxidative Heck reaction and intramolecular C-H amidation sequence
- Ruthenium catalyzed direct arylation
- Rhodium-catalyzed asymmetric conjugate addition
- Ligand-free copper-catalyzed cross-coupling reactions
- Regioselective arylation and alkynylation by Suzuki-Miyaura and Sonogashira cross-coupling reactions
- Ligand-free Suzuki, Sonogashira, and Heck cross-coupling reactions
Reagent used in Preparation of
- Catalysts for Suzuki-Miyaura cross-coupling of aryl bromides
- Recyclable Palladium nanoparticle catalysts immobilized by click ionic copolymers as for Suzuki-Miyaura cross-coupling reactions in water
4-Tolylboronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
1of3
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Panjin Greenchem Technology Co., Ltd. | 13121959385 | chemrocking@bjgreenchem.com | China | 223 | 58 |
| Shandong INOV New Materials Co., Ltd. | 18369999171 | sales2@promisechemical.com | China | 85 | 58 |
| Zhejiang Flowchem Biotechnology Co.,Ltd | 13213637321 | flowcheminnerse@163.com | China | 89 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
View Latest Price from 4-Tolylboronic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-18 | 4-Methylphenylboronic acid
5720-05-8
|
$21.00-267.00 | 25g | 0.98 | 25kg | Shanghai UCHEM Inc. | |
 |
2026-09-02 | 4-Tolylboronic acid
5720-05-8
|
$30.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-06-30 | 4-Tolylboronic acid
5720-05-8
|
1kg | 98% | 1000 | Shaanxi Dideu New Materials Co. Ltd |
-
- 4-Methylphenylboronic acid
5720-05-8
- $21.00-267.00
- 0.98
- Shanghai UCHEM Inc.
-
- 4-Tolylboronic acid
5720-05-8
- $30.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 4-Tolylboronic acid
5720-05-8
- 98%
- Shaanxi Dideu New Materials Co. Ltd
