Ethyl thiooxamate
- CAS No.
- 16982-21-1
- Chemical Name:
- Ethyl thiooxamate
- Synonyms
- ethyl 2-amino-2-thioxoacetate;ETHYL THIOXAMATE;Ethyl thiooxaMat;Ethyl 2-thiooxamate;2-ThiooxaMic Acid Ethyl Ester;O-ethyl 2-aMino-2-oxoethanethioate;NSC 174676;ETHYL THIOOXAMATE;ethylethiooxamate;O-Ethy1 thioxamate
- CBNumber:
- CB0146371
- Molecular Formula:
- C4H7NO2S
- Molecular Weight:
- 133.17
- MDL Number:
- MFCD00074903
- MOL File:
- 16982-21-1.mol
- MSDS File:
- SDS
| Melting point | 62-65 °C (lit.) |
|---|---|
| Boiling point | 199.2±23.0 °C(Predicted) |
| Density | 1.226 (estimate) |
| refractive index | 1.5480 (estimate) |
| Flash point | 74° |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | chloroform: soluble25mg/mL, clear to slightly hazy (colorless to orange) |
| form | Crystalline Powder |
| pka | 11.31±0.29(Predicted) |
| color | Yellow |
| InChI | InChI=1S/C4H7NO2S/c1-2-7-4(6)3(5)8/h2H2,1H3,(H2,5,8) |
| InChIKey | YMBMCMOZIGSBOA-UHFFFAOYSA-N |
| SMILES | C(OCC)(=O)C(N)=S |
| CAS DataBase Reference | 16982-21-1(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-37/39 | |||||||||
| RIDADR | NA1993 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29309090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| Excepted Quantities | Non-Hazardous | |||||||||
| NFPA 704 |
|
Ethyl thiooxamate price More Price(80)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | E0735 | Ethyl Thiooxamate >98.0%(GC)(N) | 16982-21-1 | 1g | $29 | 2026-04-30 | Buy |
| TCI Chemical | E0735 | Ethyl Thiooxamate >98.0%(GC)(N) | 16982-21-1 | 5g | $81 | 2026-04-30 | Buy |
| TRC | TRC-E926850-25G | Ethyl Thiooxamate | 16982-21-1 | 25g | $123 | 2026-06-03 | Buy |
| TRC | TRC-E926850-1G | Ethyl Thiooxamate | 16982-21-1 | 1g | $72 | 2026-06-03 | Buy |
| TRC | TRC-E926850-10G | Ethyl Thiooxamate | 16982-21-1 | 10g | $78 | 2026-06-03 | Buy |
Ethyl thiooxamate Chemical Properties, Uses, Production
Chemical Properties
Yellow Needles
Uses
Ethyl thiooxamate is used in a synthesis of functionalized bithiazoles.
Uses
Ethyl thiooxamate was used in the synthesis of functionalized bithiazoles.
Synthesis
623-49-4
16982-21-1
The general procedure for the synthesis of ethyl thiooxalate from ethyl cyanoformate was as follows: [(cyanocarbonyl)oxy]ethane (25 g, 0.25 mol) was dissolved with triethylamine (1 ml) in ether (200 ml) and cooled to 0°C. H2S gas was drummed into the solution for 2 hours. After completion of the reaction, the mixture was stirred at room temperature overnight, followed by replacement of the gas in the reaction system with N2. A 1N HCl solution (200 ml) was added and stirring was continued for 30 minutes. The reaction mixture was separated by extraction with ether. The organic layer was washed with brine and dried with anhydrous MgSO4. The desiccant was removed by filtration and the solvent was evaporated under reduced pressure to give ethyl thiooxalate as a yellow solid (32 g, 95% yield). The product was characterized by 1H NMR (400 MHz, chloroform-d): δ 1.37 (t, J = 7.14 Hz, 3H), 4.34 (q, J = 7.14 Hz, 2H), 7.49-8.43 (m, 2H). m/z 134 (M + H)+ was shown by LC-MS (ESI) analysis.
References
[1] Patent: US2010/196321, 2010, A1. Location in patent: Page/Page column 19
[2] Journal of Medicinal Chemistry, 2012, vol. 55, # 7, p. 3021 - 3026
[3] Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, 1983, vol. 38, # 3, p. 335 - 340
[4] Organic Syntheses, 1988, vol. 66, p. 142 - 142
[5] Patent: WO2005/37804, 2005, A1. Location in patent: Page/Page column 10
Ethyl thiooxamate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changzhou Mailekang Pharmaceutical Technology Co., Ltd. | 0519-69655553 13961137915 | mlksales@126.com | China | 62 | 58 |
| Tianjin Ruide Famo Technology Co., Ltd | 13821803402 | RD_PHARM@163.com | China | 842 | 58 |
| Chongqing Sennod Medical Co., Ltd | 15086900926 | 461967281@qq.com | China | 42 | 58 |
| Fujian Fine New Material Technology Co., Ltd. | 18173168888 | 24314994600@qq.com | China | 96 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| future industrial shanghai co., ltd | 400-0066400 13621662912 | sales@jonln.com | China | 1989 | 65 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
View Latest Price from Ethyl thiooxamate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-03-20 | Ethyl thiooxamate
16982-21-1
|
$10.00 | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-09-16 | Ethyl thiooxamate
16982-21-1
|
$1.00 | 1kg | 98% | 500kg | Nanjing Kaitian Chemical Co., LTD | |
 |
2024-04-25 | Ethyl thiooxamate
16982-21-1
|
$30.00 | 1kg | 99.7% | 200000kg | Ouhuang Engineering Materials (Hubei) Co., Ltd |
-
- Ethyl thiooxamate
16982-21-1
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- Ethyl thiooxamate
16982-21-1
- $1.00
- 98%
- Nanjing Kaitian Chemical Co., LTD
-
- Ethyl thiooxamate
16982-21-1
- $30.00
- 99.7%
- Ouhuang Engineering Materials (Hubei) Co., Ltd
