Glycine ethyl ester hydrochloride
- CAS No.
- 623-33-6
- Chemical Name:
- Glycine ethyl ester hydrochloride
- Synonyms
- ETHYL GLYCINATE HYDROCHLORIDE;GLYCINE ETHYL ESTER;GLYCINE ETHYL ESTER HCL;GEE;H-GLY-OET HCL;ETHYL AMINOACETATE HYDROCHLORIDE;usafdo-10;ycine EthyL;Gly-OEt HCl;GLYCINE-OET HCL
- CBNumber:
- CB5275670
- Molecular Formula:
- C4H9NO2.ClH
- Molecular Weight:
- 139.58
- MDL Number:
- MFCD00012871
- MOL File:
- 623-33-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Glycine ethyl ester hydrochloride 99% | G6503 | 5G | $38.8 |
| Glycine ethyl ester hydrochloride 99% | G6503 | 100g | $72 |
| Glycine ethyl ester hydrochloride 99% | G6503 | 500g | $108 |
| Glycine Ethyl Ester Hydrochloride >99.0%(T) | G0102 | 25g | $17 |
| Glycine Ethyl Ester Hydrochloride >99.0%(T) | G0102 | 500g | $64 |
| More product size | |||
| Melting point | 145-146 °C(lit.) |
|---|---|
| Density | 1.371 g/cm3 |
| storage temp. | 2-8°C |
| solubility | >1000 g/L (20 °C) |
| pka | pK1:7.66(＋1) (25°C) |
| form | Crystalline Powder |
| color | White |
| Odor | Odorless |
| PH | 2.9 (10g/l, H2O, 20℃) |
| Water Solubility | >1000 g/L (20 ºC) |
| Sensitive | Hygroscopic |
| BRN | 3594034 |
| Major Application | peptide synthesis |
| InChI | 1S/C4H9NO2.ClH/c1-2-7-4(6)3-5;/h2-3,5H2,1H3;1H |
| InChIKey | TXTWXQXDMWILOF-UHFFFAOYSA-N |
| SMILES | Cl.CCOC(=O)CN |
| CAS DataBase Reference | 623-33-6(CAS DataBase Reference) |
| EPA Substance Registry System | Glycine, ethyl ester, hydrochloride (623-33-6) |
| UNSPSC Code | 12352209 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H318 | |||||||||
| Precautionary statements | P280-P305+P351+P338 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 41-36/37/38 | |||||||||
| Safety Statements | 26-39-24/25-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | MC0525000 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29224995 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Dam. 1 | |||||||||
| NFPA 704 |
|
Glycine ethyl ester hydrochloride price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | G6503 | Glycine ethyl ester hydrochloride 99% | 623-33-6 | 5G | $38.8 | 2026-03-19 | Buy |
| Sigma-Aldrich | G6503 | Glycine ethyl ester hydrochloride 99% | 623-33-6 | 100g | $72 | 2026-03-19 | Buy |
| Sigma-Aldrich | G6503 | Glycine ethyl ester hydrochloride 99% | 623-33-6 | 500g | $108 | 2026-03-19 | Buy |
| TCI Chemical | G0102 | Glycine Ethyl Ester Hydrochloride >99.0%(T) | 623-33-6 | 25g | $17 | 2026-03-19 | Buy |
| TCI Chemical | G0102 | Glycine Ethyl Ester Hydrochloride >99.0%(T) | 623-33-6 | 500g | $64 | 2026-03-19 | Buy |
Glycine ethyl ester hydrochloride Chemical Properties,Uses,Production
Chemical Properties
Crystalline
Uses
As a Glycine (G615990) ester, Glycine ethyl ester hydrochloride can be used as parakeratosis inhibitor and external composition for skin.
Uses
Glycine ethyl ester (GEE) is used in conjunction with N-(3-Dimethylaminopropyl)-N-ethylcarbodiimide (EDC) for carboxyl-foot printing studies of proteins. The GEE/EDC protocol effects specific derivatization of glutamate and aspartate carboxyl side chains on intact proteins. This reaction is readily done under aqueous conditions at physiological pH. It is mainly used as a pharmaceutical raw material. Glycine ethyl ester hydrochloride is an important intermediate for preparing chrysanthemic acid or two chlorine chrysanthemic acid and is mainly used in the synthesis of anti-inflammatory drugs, but also can be used for the synthesis of four imidazole acetic acid.
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
A production method for glycine ethyl ester hydrochloride:First add dehydrated ethanol in 1# reactor, pass into anhydrous hydrogen chloride to obtain hydrochloric acid-ethanol solution; Add a certain amount of triethyl orthoformate and glycine and hydrochloric acid-ethanol solution in 2# reactor, in the Reaction under action; after the reaction is complete, distill and recover ethanol and ethyl formate; then add alcohol-ether mixture, wash, filter, concentrate, recrystallize, and vacuum dry to obtain ethyl glycine hydrochloride.
Purification Methods
Crystallise it from absolute EtOH or EtOH/Et2O. [Marvel Org Synth Coll Vol II 310 1943, Beilstein 4 II 780, 4 III 3 75.]
References
[1] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2006, vol. 45, # 8, p. 1942 - 1944
[2] Patent: US2003/236253, 2003, A1. Location in patent: Page 12
[3] Patent: CN107652265, 2018, A. Location in patent: Paragraph 0040; 0041
[4] Journal of Medicinal Chemistry, 2012, vol. 55, # 1, p. 55 - 67
[5] Patent: CN105820102, 2016, A. Location in patent: Paragraph 0038
Glycine ethyl ester hydrochloride Preparation Products And Raw materials
Raw materials
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Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1803 | 55 |
| Shandong Believe Chemical PTE.LTD | +86-18553607090 +8618553607090 | 1093908296@qq.com | China | 1663 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 +8613131129325 | sales1@chuanghaibio.com | China | 5235 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 973 | 58 |
| Sichuan HongRi Pharma-Tech Co.,Ltd | +8618382028708 | ni@enlaibio.com | China | 1098 | 58 |
| Shandong Deshang Chemical Co., Ltd. | +86-0531-8875-2665 +8613153039501 | info@deshangchem.com | China | 661 | 58 |
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 | niki@zlchemi.com | China | 7245 | 58 |
| Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 | sales@frappschem.com | China | 880 | 50 |
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View Lastest Price from Glycine ethyl ester hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-24 | Glycine ethyl ester hydrochloride
623-33-6
|
US $0.00-0.00 / kg | 1kg | 98%min | 10000kg | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2026-04-24 | H-Gly-Oet.HCl
623-33-6
|
US $0.00-0.00 / kg | 1kg | 98% | 1T+ | Sichuan HongRi Pharma-Tech Co.,Ltd | |
 |
2026-03-20 | Glycine ethyl ester hydrochloride
623-33-6
|
US $10.00 / KG | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd |
-
- Glycine ethyl ester hydrochloride
623-33-6
- US $0.00-0.00 / kg
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- H-Gly-Oet.HCl
623-33-6
- US $0.00-0.00 / kg
- 98%
- Sichuan HongRi Pharma-Tech Co.,Ltd
-
- Glycine ethyl ester hydrochloride
623-33-6
- US $10.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
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