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4-Quinazolinamine, N-(5-phenyl-1H-pyrazol-3-yl)-2-(4-pyridinyl)-

4-Quinazolinamine, N-(5-phenyl-1H-pyrazol-3-yl)-2-(4-pyridinyl)- structure

CAS No.: 1802068-51-4

Chemical Name:: 4-Quinazolinamine, N-(5-phenyl-1H-pyrazol-3-yl)-2-(4-pyridinyl)-

Synonyms: UNI418;N-(5-phenyl-1H-pyrazol-3-yl)-2-(pyridin-4-yl)quinazolin-4-amine;4-Quinazolinamine, N-(5-phenyl-1H-pyrazol-3-yl)-2-(4-pyridinyl)-

CBNumber:: CB014686359

Molecular Formula:: C22H16N6

Molecular Weight:: 364.4

MDL Number:

MOL File:: 1802068-51-4.mol

MSDS File:: SDS

Last updated:2025-04-18 09:51:27

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4-Quinazolinamine, N-(5-phenyl-1H-pyrazol-3-yl)-2-(4-pyridinyl)- Properties

Boiling point	573.5±50.0 °C(predicted)
Density	1.342±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
form	Solid
pka	13.17±0.10(predicted)
color	Off-white to light brown

4-Quinazolinamine, N-(5-phenyl-1H-pyrazol-3-yl)-2-(4-pyridinyl)- price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-1180904	UNI418 99.61%	1802068-51-4	5mg	$368	2026-06-04	Buy
ChemScene	CS-1180904	UNI418 99.61%	1802068-51-4	10mg	$596	2026-06-04	Buy
ChemScene	CS-1180904	UNI418 99.61%	1802068-51-4	25mg	$1192	2026-06-04	Buy
ChemScene	CS-1180904	UNI418 99.61%	1802068-51-4	50mg	$1928	2026-06-04	Buy
Arctom	HY-163943	UNI418 99.61%	1802068-51-4	5mg	$323	2026-05-26	Buy

Product number	Packaging	Price	Buy
CS-1180904	5mg	$368	Buy
CS-1180904	10mg	$596	Buy
CS-1180904	25mg	$1192	Buy
CS-1180904	50mg	$1928	Buy
HY-163943	5mg	$323	Buy

4-Quinazolinamine, N-(5-phenyl-1H-pyrazol-3-yl)-2-(4-pyridinyl)- Chemical Properties,Uses,Production

Uses

UNI418 is a dual inhibitor of PIKfyve and PIP5K1C with antiviral activity against SARS-CoV-2 (EC50=1.4 μM). UNI418 blocks ACE2-mediated SARS-CoV-2 viral endocytosis by inhibiting PIP5K1C (IC50=60.1 nM; Kd=61 nM). In addition, UNI418 inhibits the proteolytic activation of proteases regulated by PIKfyve (Kd=0.78 nM) to prevent SARS-CoV-2 from entering host cells[1].

References

[1] Seo, et al. "A dual inhibitor of PIP5K1C and PIKfyve prevents SARS-CoV-2 entry into cells." Experimental & Molecular Medicine (2024): 1-14. DOI:10.1038/s12276-024-01283-2

4-Quinazolinamine, N-(5-phenyl-1H-pyrazol-3-yl)-2-(4-pyridinyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

4-Quinazolinamine, N-(5-phenyl-1H-pyrazol-3-yl)-2-(4-pyridinyl)- Suppliers

Global( 5)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai SuperLan Chemcial Technique Centre	0-2022843681 15618226720	chaolaichem@foxmail.com	China	10000	58
ShangHai Caerulum Pharma Discovery Co., Ltd.	15000803246 18149758185	sales-cpd@caerulumpharma.com	China	473	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29874	58
Zhejiang Huida Biotech Co., Ltd.	0571-89903022 18679456698	zilong@hizyme.com	China	7853	58

Supplier	Advantage
Shanghai SuperLan Chemcial Technique Centre	58
ShangHai Caerulum Pharma Discovery Co., Ltd.	58
TargetMol Chemicals Inc.	58
Zhejiang Huida Biotech Co., Ltd.	58

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4-Quinazolinamine, N-(5-phenyl-1H-pyrazol-3-yl)-2-(4-pyridinyl)- N-(5-phenyl-1H-pyrazol-3-yl)-2-(pyridin-4-yl)quinazolin-4-amine UNI418 1802068-51-4