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VEGFR-2-IN-52

VEGFR-2-IN-52 Structure
VEGFR-2-IN-52 structure
CAS No.
3046428-94-5
Chemical Name:
VEGFR-2-IN-52
Synonyms
VEGFR-2-IN-52;3-Thiophenecarboxamide, 4-(4-chlorophenyl)-2-[[[[4-(1-pyrrolidinyl)butyl]amino]carbonyl]amino]-
CBNumber:
CB014907874
Molecular Formula:
C20H25ClN4O2S
Molecular Weight:
420.96
MDL Number:
MOL File:
3046428-94-5.mol
Last updated:2025-04-18 09:51:26
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VEGFR-2-IN-52 Properties

Boiling point 552.5±50.0 °C(predicted)
Density 1.307±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka 12.51±0.46(predicted)

VEGFR-2-IN-52 Chemical Properties, Uses, Production

Uses

VEGFR-2-IN-52 (compound 14d) is a potent VEGFR-2 inhibitor with an IC50 value of 191.1 nM. VEGFR-2-IN-52 decreases the protein expression of p-VEGFR-2, MMP9, p-ERK1/2 and p-MEK1. VEGFR-2-IN-52 shows cytotoxicity. VEGFR-2-IN-52 induces apoptosis and cell cycle arrest at G0/G1 phase. VEGFR-2-IN-52 increases the levels of ROS[1].

References

[1] Li T, et al. Discovery of novel thiophene-3-carboxamide derivatives as potential VEGFR-2 inhibitors with anti-angiogenic properties. Bioorg Chem. 2024 Jun;147:107358. DOI:10.1016/j.bioorg.2024.107358

VEGFR-2-IN-52 Preparation Products And Raw materials

Raw materials

Preparation Products

VEGFR-2-IN-52 Suppliers

Global Suppliers ( 1)
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
Supplier Advantage
TargetMol Chemicals Inc. 58

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VEGFR-2-IN-52 3-Thiophenecarboxamide, 4-(4-chlorophenyl)-2-[[[[4-(1-pyrrolidinyl)butyl]amino]carbonyl]amino]- 3046428-94-5