4-Bromo-isothiazole
- CAS No.
- 24340-77-0
- Chemical Name:
- 4-Bromo-isothiazole
- Synonyms
- 4-Bromo-isothiazole;4-broMo-1,2-thiazole;ISOTHIAZOLE, 4-BROMO-;4-Bromoisothiazole USP/EP/BP;4-Bromoisothiazole≥ 95% (NMR)
- CBNumber:
- CB0149473
- Molecular Formula:
- C3H2BrNS
- Molecular Weight:
- 164.02
- MDL Number:
- MFCD06657593
- MOL File:
- 24340-77-0.mol
- TDS File:
- TDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| HS Code | 2934100090 |
4-Bromo-isothiazole price More Price(65)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 265707 | 4-Bromoisothiazole ≥97% | 24340-77-0 | 1g | $240 | 2026-06-03 | Buy |
| Usbiological | 265707 | 4-Bromoisothiazole ≥97% | 24340-77-0 | 5g | $644 | 2026-06-03 | Buy |
| Activate Scientific | AS15250 | 4-(Bromo)isothiazole 98% | 24340-77-0 | 1g | $131 | 2026-06-04 | Buy |
| Activate Scientific | AS15250 | 4-(Bromo)isothiazole 98% | 24340-77-0 | 5g | $503 | 2026-06-04 | Buy |
| Chem-Impex | 17479 | 4-Bromoisothiazole ≥95%(NMR) | 24340-77-0 | 250MG | $58.39 | 2026-05-19 | Buy |
4-Bromo-isothiazole Chemical Properties, Uses, Production
Application
4-Bromoisothiazol is a pharmaceutical intermediate that can be prepared by one-step bromination of isothiazole and can be used to prepare Bcr-Abl1 kinase inhibitors.
Chemical Properties
White to off-white solid
Synthesis
288-16-4
24340-77-0
General procedure for the synthesis of 4-bromoisothiazole from isothiazole: Bromine (12.5 g, 78.12 mmol) was added slowly and dropwise to a solution of isothiazole (5.0 g, 58.82 mmol) in acetic acid (37 mL) over a period of 20 min at 95 °C. The reaction mixture was stirred continuously at 95 °C for 6 h and subsequently cooled to room temperature. The cooled mixture was poured into ice water (100 mL). The resulting mixture was extracted with ether (200 mL x 2). The organic phases were combined and washed with 6N sodium hydroxide solution to pH 7-8, followed by drying with anhydrous sodium sulfate and filtration. The filtrate was concentrated under reduced pressure and the resulting residue was purified by distillation to give 4-bromoisothiazole as a white solid (1.5 g, 15% yield).
References
[1] Patent: WO2017/176961, 2017, A1. Location in patent: Paragraph 00375
[2] Journal of Medicinal Chemistry, 1968, vol. 11, # 1, p. 70 - 73
4-Bromo-isothiazole Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Carlow Chemicals Co., Ltd. | 21-33526724 18930996265 | info@carlowchem.com | China | 1820 | 50 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| China DongFan Chemical Co.,LTD | 86-0571-85151182 | China | 5681 | 66 |
View Latest Price from 4-Bromo-isothiazole manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-26 | 24340-77-0
24340-77-0
|
1g | 95%min | 20kg/month | Nanjing jinheyou Trading Co., Ltd. | ||
 |
2019-07-06 | 4-BROMO-ISOTHIAZOLE
24340-77-0
|
$1.00 | 1KG | 96% | 500kg | Career Henan Chemical Co |
-
- 24340-77-0
24340-77-0
- $0.00
- 95%min
- Nanjing jinheyou Trading Co., Ltd.
-
- 4-BROMO-ISOTHIAZOLE
24340-77-0
- $1.00
- 96%
- Career Henan Chemical Co
