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ethyl 4-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate

ethyl 4-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate structure

CAS No.: 942920-55-0

Chemical Name:: ethyl 4-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate

Synonyms: ethyl 4-broMo-1H-pyrrolo[2;3-b]pyridine-2-carboxylate;ethyl 6-chloro-1H-pyrrolo[2;Ethyl 4-Bromo-7-azaindole-2-carboxylate;ethyl 4-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate;1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, 4-broMo-, ethyl ester

CBNumber:: CB01560987

Molecular Formula:: C10H9BrN2O2

Molecular Weight:: 269.09

MDL Number:: MFCD11518924

MOL File:: 942920-55-0.mol

MSDS File:: SDS

Last updated:2026-05-27 17:21:06

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ethyl 4-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate Properties

Density	1.624±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
pka	10.96±0.40(Predicted)
Appearance	White to off-white Solid
InChI	InChI=1S/C10H9BrN2O2/c1-2-15-10(14)8-5-6-7(11)3-4-12-9(6)13-8/h3-5H,2H2,1H3,(H,12,13)
InChIKey	VLZWUULVFAASBC-UHFFFAOYSA-N
SMILES	C12NC(C(OCC)=O)=CC1=C(Br)C=CN=2

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS06
Signal word	Danger
Hazard statements	H300-H312-H315-H319
Precautionary statements	P501-P270-P264-P280-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P310+P330-P302+P352+P312-P405

ethyl 4-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate price More Price(38)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
AstaTech	SC3471	ETHYL 4-BROMO-1H-PYRROLO[2,3-B]PYRIDINE-2-CARBOXYLATE 95%	942920-55-0	0.25G	$147	2026-04-30	Buy
AstaTech	SC3471	ETHYL 4-BROMO-1H-PYRROLO[2,3-B]PYRIDINE-2-CARBOXYLATE 95%	942920-55-0	1G	$276	2026-04-30	Buy
Matrix Scientific	305103	Ethyl 4-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate	942920-55-0	100.00mg	$63	2026-05-19	Buy
Matrix Scientific	305103	Ethyl 4-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate	942920-55-0	250.00mg	$110	2026-05-19	Buy
Matrix Scientific	305103	Ethyl 4-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate	942920-55-0	1.00g	$291	2026-05-19	Buy

Product number	Packaging	Price	Buy
SC3471	0.25G	$147	Buy
SC3471	1G	$276	Buy
305103	100.00mg	$63	Buy
305103	250.00mg	$110	Buy
305103	1.00g	$291	Buy

ethyl 4-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate Chemical Properties, Uses, Production

Uses

Ethyl 4-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate is used in pharmaceutical synthesis and experiments.

Synthesis

1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, ethyl ester, 7-oxide

287384-82-1

942920-55-0

Step A: Synthesis of ethyl 4-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate Ethyl 1H-pyrrolo[2,3-b]pyridine-2-carboxylate-7-oxide (1 g, 5 mmol) (prepared according to the method disclosed in WO 2000/044753, see Example 6, Step C) was added to a suspension of tetramethylammonium bromide (1.2 g, 7.5 mmol) in N,N-dimethylformamide (50 mL). The reaction mixture was cooled to 0 °C, followed by batchwise addition of methylsulfonic anhydride (1.7 g, 10 mmol). The mixture was warmed to room temperature and stirring was continued for 6 hours. Upon completion of the reaction, the mixture was poured into water (100 mL) and neutralized with 50% aqueous sodium hydroxide solution. The aqueous phase was extracted with ethyl acetate and the organic layer was washed sequentially with brine and deionized water. The organic phase was concentrated under reduced pressure to give the crude product. Purification by SCX column chromatography afforded ethyl 4-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate as a light yellow solid (1 g, 77% yield). 1H NMR (400MHz, DMSO-d6) δ ppm: 1.35 (t, 3H, J=7.1Hz), 4.36 (q, 2H, J=7.1Hz), 7.05 (d, 1H, J=2.0Hz), 7.48 (d, 1H, J=5.1Hz), 8.28 (d, 1H, J=5.1Hz), 12.95 (brs , 1H).

References

[1] Journal of Medicinal Chemistry, 2010, vol. 53, # 10, p. 3973 - 4001
[2] Patent: WO2008/49855, 2008, A2. Location in patent: Page/Page column 54
[3] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 16, p. 4610 - 4614
[4] Patent: US2009/18156, 2009, A1. Location in patent: Page/Page column 18-19
[5] Patent: WO2007/76423, 2007, A2. Location in patent: Page/Page column 96

ethyl 4-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate Preparation Products And Raw materials

Raw materials

1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, ethyl ester, 7-oxide Methanesulfonic anhydride Water N,N-Dimethylformamide Tetrabutylammomium bromide

Sodium hydroxide

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Preparation Products

1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, ethyl ester

ethyl 4-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate Suppliers

Global Suppliers ( 97)

Supplier	Tel	Email	Country	ProdList	Advantage
Xi 'an fanta biotechnology co., LTD	19929974101 //1144079830; 19929974101	1144079830@qq.com	China	952	58
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
JinYan Chemicals(ShangHai) Co.,Ltd.	13817811078	sales@jingyan-chemical.com	China	9963	60
Shangchem Co., Ltd.	+86-21-68182121		China	881	52
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62
Shanghai Longsheng chemical Co.,Ltd.	58099637 13585536065	sales@shlschem.com	China	9880	59
skychemical Co.Ltd	021-20958197 20965099	sales@skychemical.com	China	1182	57
Wuhan TCASChem Technology Co., Ltd.	027-86697669 13986148687	sales@tcaschem.com	China	3987	55
Shanghai Topbiochem Technology Co., Ltd	+86-21-60341587	sales@topbiochem.com	China	6166	58
Nanjing Norris-Pharm Technology Co., Ltd	13901585132	sales@norris-pharm.com	China	8869	55

Supplier	Advantage
Xi 'an fanta biotechnology co., LTD	58
Capot Chemical Co., Ltd	66
JinYan Chemicals(ShangHai) Co.,Ltd.	60
Shangchem Co., Ltd.	52
Pure Chemistry Scientific Inc.	62
Shanghai Longsheng chemical Co.,Ltd.	59
skychemical Co.Ltd	57
Wuhan TCASChem Technology Co., Ltd.	55
Shanghai Topbiochem Technology Co., Ltd	58
Nanjing Norris-Pharm Technology Co., Ltd	55

View Latest Price from ethyl 4-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-12-26	ethyl 4-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate 942920-55-0	$1.00	1KG	99%	200kg	Career Henan Chemical Co

ethyl 4-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate
942920-55-0
$1.00
99%
Career Henan Chemical Co

ethyl 4-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate Spectrum

ethyl 4-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate(942920-55-0)¹HNMR

942920-55-0 (ethyl 4-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate) Related Search:

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1of2

ethyl 4-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate 3-b]pyridine-2-carboxylate ethyl 4-broMo-1H-pyrrolo[2 ethyl 6-chloro-1H-pyrrolo[2 1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, 4-broMo-, ethyl ester Ethyl 4-Bromo-7-azaindole-2-carboxylate 942920-55-0 Heterocycle-Pyridine series CHIRAL CHEMICALS