Donepezil
- CAS No.
- 120014-06-4
- Chemical Name:
- Donepezil
- Synonyms
- 5,6-Dimethoxy-2,3-dihydro-1H-inden-1-one;Donepenil;Donezepil;2-[(1-benzyl-4-piperidyl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one;2-((1-Benzylpiperidin-4-yl)Methyl)-5,6-diMethoxy-2,3-dihydro-1H-inden-1-one;Donepezilo;Donepezil hydrochloride monohydrate;N-Benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl] piperidine;2,3-dihydro-5,6-dimethoxy-2-((1-(phenylmethyl)-4-piperidinyl)methyl)-1h-inde;n-1-one
- CBNumber:
- CB0156314
- Molecular Formula:
- C24H29NO3
- Molecular Weight:
- 379.49
- MDL Number:
- MFCD00912833
- MOL File:
- 120014-06-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 207°C |
|---|---|
| Boiling point | 527.9±50.0 °C(Predicted) |
| Density | 1.141±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Acetone (Slightly), Chloroform (Slightly) |
| form | Solid |
| pka | 8.84±0.10(Predicted) |
| color | White to Off-White |
| Water Solubility | 2.931 mg/L |
| Henry's Law Constant | 8.2×106 mol/(m3Pa) at 25℃, HSDB (2015) |
| InChI | InChI=1S/C24H29NO3/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18/h3-7,14-15,17,20H,8-13,16H2,1-2H3 |
| InChIKey | ADEBPBSSDYVVLD-UHFFFAOYSA-N |
| SMILES | C1(=O)C2=C(C=C(OC)C(OC)=C2)CC1CC1CCN(CC2=CC=CC=C2)CC1 |
| CAS DataBase Reference | 120014-06-4(CAS DataBase Reference) |
| NCI Dictionary of Cancer Terms | donepezil |
| FDA UNII | 8SSC91326P |
| ATC code | N06DA02 |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-36/37/39 | |||||||||
| RIDADR | UN 2811 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| HS Code | 29333990 | |||||||||
| Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials |
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| Hazard Classifications | Acute Tox. 2 Oral Eye Irrit. 2 |
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| Hazardous Substances Data | 120014-06-4(Hazardous Substances Data) | |||||||||
| NFPA 704 |
|
Donepezil price More Price(47)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | Y0002165 | Donepezil for system suitability CRS, European Pharmacopoeia (EP) Reference Standard | 120014-06-4 | 10 mg | $172 | 2026-04-30 | Buy |
| Cayman Chemical | 13245 | Donepezil ≥95% | 120014-06-4 | 10mg | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 13245 | Donepezil ≥95% | 120014-06-4 | 25mg | $81 | 2026-04-30 | Buy |
| Cayman Chemical | 13245 | Donepezil ≥95% | 120014-06-4 | 50mg | $134 | 2026-04-30 | Buy |
| Cayman Chemical | 13245 | Donepezil ≥95% | 120014-06-4 | 100mg | $253 | 2026-04-30 | Buy |
Donepezil Chemical Properties, Uses, Production
Description
Donepezil is another “nonclassic,” centrally acting, reversible, noncompetitive AChEI that was approved in 1997 for treatment of mild-to-moderate AD and dementia. Its selectivity for AChE is 570- to 1,250-fold that for butyrylcholinesterase, and it also exhibits greater affinity for brain AChE than for AChE in the periphery.
Uses
Donepezil is a cholinesterase inhibitors.
Uses
Acetylcholine is a neurotransmitter involved in neural signaling throughout the body. Donepezil is a reversible acetylcholinesterase inhibitor that readily crosses the blood-brain barrier to reduce the breakdown of acetylcholine. It has a half-life in circulation of about 70 hours. As acetylcholine modulates plasticity, excitability, and arousal in the central nervous system, donepezil is commonly used in the treatment of Alzheimer’s disease to improve cognition, memory, and behavior. In this way, it is intended to prevent or reverse dementia. Studies on these effects have been equivocal, indicating that more research into the therapeutic potential of donepezil is warranted.[Cayman Chemical]
Definition
ChEBI: Donepezil is a centrally acting reversible acetyl cholinesterase inhibitor. Its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
brand name
Aricept (Eisai Medical Research).
General Description
Donepezil, (±)-2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one (Aricept), commonly referred to in the literature asE2020, is a reversible inhibitor of AChE. It is indicated forthe treatment of symptoms of mild-to-moderate Alzheimerdisease. Donepezil is approximately 96% bound to plasmaproteins, with an elimination half-life of 70 hours. It is metabolizedprincipally by the 2D6 and 3A4 isozymes of theP450 system.
Metabolism
When compared to tacrine, donepezil exhibits greater CNS AChE selectivity, longer elimination half-life (70–104 hours in subjects older than 55 years) and little or no potential for hepatotoxicity. Donepezil is metabolized by CYP2D6 and CYP3A4 via demethylation, debenzylation, hydroxylation, oxidation to the cis-N-oxide, and glucuronidation. The 6-O-desmethyl metabolite accounts for 11% of a dose, and it exhibits AChE inhibitory activity comparable to that of the parent compound.
Donepezil Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Anhui Dexinjia Biopharm Co., Ltd | 0531-82375893 15553111391 | phoebe@jndxj.com | China | 285 | 58 |
| MedicalChem(Yancheng)Manuf.Co.,Ltd | +86-515-84383180 | sales@medicalchem.com | China | 80 | 69 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2110 | 70 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| XiaoGan ShenYuan ChemPharm co,ltd | 15527621225; 15527621225 | 1791901229@qq.com | China | 6742 | 52 |
| Shanghai Ennopharm Co., Ltd. | +86 (21) 6435-5022 | China | 4263 | 65 |
View Latest Price from Donepezil manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-16 | Donepezil
120014-06-4
|
1KG | 99%min | 1200kg/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-09-14 | Donepezil
120014-06-4
|
2Kg/Bag | 99% up, High Density | 20 tons | Sinoway Industrial co., ltd. | ||
 |
2026-08-21 | Donepezil
120014-06-4
|
$150.00-280.00 | 1g | 99% | 1000KG | Hebei Dangtong Import and export Co LTD |
