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2,5-Dimethyl pyrazine

2,5-Dimethyl pyrazine structure

CAS No.: 123-32-0

Chemical Name:: 2,5-Dimethyl pyrazine

Synonyms: 2,5-DIMETHYLPYRAZINE;Pyrazine,2,5-dimethyl-;2,5-Dimethylprazin;FEMA 3272;2,5-Dimethyl;Structural formula;2,5-Dimethylpiazine;2,5-dimethyl-pyrazin;tomfor;KETINE

CBNumber:: CB0159355

Molecular Formula:: C6H8N2

Molecular Weight:: 108.14

MDL Number:: MFCD00006147

MOL File:: 123-32-0.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-17 09:03:53

Product description	Number	Pack Size	Price
2,5-Dimethylpyrazine ≥98%, FG	W327204	1 each	$55.9
2,5-Dimethylpyrazine ≥98%, FG	W327204	100g	$94.1
2,5-Dimethylpyrazine ≥98%, FG	W327204	500g	$263
2,5-Dimethylpyrazine ≥98%, FG	W327204	1kg	$382
2,5-Dimethylpyrazine 98%	175420	5g	$45.9
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2,5-Dimethyl pyrazine Properties

Melting point	15°C
Boiling point	155 °C (lit.)
Density	0.99 g/mL at 25 °C (lit.)
refractive index	n20/D 1.502(lit.)
FEMA	3272 \| 2,5-DIMETHYLPYRAZINE
FLAVIS Number	14.020 \| 2,5-Dimethylpyrazine
Flash point	147 °F
storage temp.	Inert atmosphere,Room Temperature
solubility	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka	2.21±0.10(Predicted)
form	Liquid
Specific Gravity	0.990
color	Clear colorless to pale yellow
PH	7 (H2O)
Odor	at 0.10 % in dipropylene glycol. nutty roasted baked potato
Odor Type	chocolate
biological source	synthetic
Sensitive	Hygroscopic
JECFA Number	766
BRN	107052
Henry's Law Constant	7.1×10⁰ mol/(m³Pa) at 25℃, Marin et al. (1999)
Dielectric constant	2.4399999999999999
Cosmetics Ingredients Functions	PERFUMING
InChI	1S/C6H8N2/c1-5-3-8-6(2)4-7-5/h3-4H,1-2H3
InChIKey	LCZUOKDVTBMCMX-UHFFFAOYSA-N
SMILES	Cc1cnc(C)cn1
LogP	0.64
CAS DataBase Reference	123-32-0(CAS DataBase Reference)
Substances Added to Food (formerly EAFUS)	2,5-DIMETHYLPYRAZINE
EWG's Food Scores	1
FDA UNII	V99Y0MUY1Q
NIST Chemistry Reference	Pyrazine, 2,5-dimethyl-(123-32-0)
EPA Substance Registry System	Pyrazine, 2,5-dimethyl- (123-32-0)
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P301+P312+P330

PPE

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Codes

Xn,Xi

Risk Statements

22-36/37/38-R22

Safety Statements

26-36

RIDADR

NA 1993 / PGIII

WGK Germany

RTECS

UQ2800000

Hazard Note

Irritant

TSCA

TSCA listed

HS Code

29339990

Storage Class

10 - Combustible liquids

Hazard Classifications

Acute Tox. 4 Oral

NFPA 704

	2
		0

2,5-Dimethyl pyrazine price More Price(86)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	W327204	2,5-Dimethylpyrazine ≥98%, FG	123-32-0	1 each	$55.9	2026-04-30	Buy
Sigma-Aldrich	W327204	2,5-Dimethylpyrazine ≥98%, FG	123-32-0	100g	$94.1	2026-04-30	Buy
Sigma-Aldrich	W327204	2,5-Dimethylpyrazine ≥98%, FG	123-32-0	500g	$263	2026-04-30	Buy
Sigma-Aldrich	W327204	2,5-Dimethylpyrazine ≥98%, FG	123-32-0	1kg	$382	2026-04-30	Buy
Sigma-Aldrich	175420	2,5-Dimethylpyrazine 98%	123-32-0	5g	$45.9	2026-04-30	Buy

Product number	Packaging	Price	Buy
W327204	1 each	$55.9	Buy
W327204	100g	$94.1	Buy
W327204	500g	$263	Buy
W327204	1kg	$382	Buy
175420	5g	$45.9	Buy

2,5-Dimethyl pyrazine Chemical Properties,Uses,Production

Chemical Properties

clear colorless to pale yellow liquid

Chemical Properties

2,5-Dimethylpyrazine has a characteristic odor of earthy, potato-like odor.

Occurrence

Reported to be present in bakery products, roasted barley, cocoa products, roasted coffee, dairy products, pork, peanuts, pecans, filberts, popcorn, potato products, rum and whiskey, soy products; a volatile component in roasted filberts and in potato chips; reportedly identified in the fat of cooked beef; also reported found in toasted off-flavors. Also reported in cheeses, butter, boiled eggs, grilled beef, tea, barley, oats, oatmeal, soybeans, heated beans, kohlrabi, shrimp and mushrooms. Also reported found in coffee, potato chips and shrimp

Uses

2,5-Dimethyl pyrazine is used for blending food, nuts and beverage flavors.

Uses

2,5-Dimethylpyrazine is used as a reagent in the synthesis of bone-targeted proteasome inhibitors for multiple myeloma (MM). 2,5-Dimethylpyrazine is also used in the preparation of 3-Methyl-2,5-bis-(2-hydroxyethyl)pyrazine (M295340); a degredation product of Clavulanic Acid (C563750) which is a β-lactamase inhibitor, typically added to amoxicillin to increase its effectiveness.

Definition

ChEBI: 2,5-Dimethylpyrazine is a member of pyrazines.

Application

2,5-Dimethyl pyrazine is held chiefly responsible for the typical flavor of Potato Chips (oil-fried, thin-sliced Potato). It has therefore been manufactured synthetically and is used in the reconditioning of commercial products, such as Potato Chips and the packaging material for same, and also for reconditioning of "instant" coffee.

Preparation

By the interaction of acrolein and ammonia when heated in glycerol in the presence of ammonium salts; by self-condensation of aminoacetone, followed by oxidation with mercury chloride.

Aroma threshold values

Detection: 80 ppb to 1.8 ppm

Taste threshold values

Taste characteristics at 7.5 ppm: musty, potato, cocoa and nutty with a fatty and oily nuance

General Description

2,5-Dimethylpyrazine is a pyrazine compound that is mainly formed in food products such as cooked rice or roasted peanuts due to the Maillard reaction between sugars and proteins during cooking or roasting process.

Safety Profile

Moderately toxic by ingestion and intraperitoneal routes. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx

Purification Methods

Purify it via its picrate (m 150o) which is decomposed with a base (e,g, KOH) and distilled. [Wiggins and Wise J Chem Soc 4780 1956]. [Beilstein 23/5 V 403.]

2,5-Dimethyl pyrazine synthesis

Synthesis of 2,5-Dimethyl pyrazine from (±)-1-Amino-2-propanol

2,5-Dimethyl pyrazine Preparation Products And Raw materials

Raw materials

Acrolein Pyrazine, 2,5-dimethyl-3-propyl- (8CI,9CI) 2-Methyl-5-sec-butylpyrazine azidoacetone 2,4-OCTADIENE

2-methyl-5-propyl-pyrazine 1,3-OCTADIENE 2-AMINO-2-PROPANOL (E)-2-oxopropanal oxime 2-ISOBUTYL-3-METHYLPYRAZINE

AMINOACETONE HYDROCHLORIDE DL-Alaninol 2,6-Dimethylpiperazine

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Preparation Products

trans-2,5-Dimethylpiperazine 2,6-Dimethylpyrazine Pyrimidine, 2,4-dimethyl- (6CI,7CI,8CI,9CI) Pyrazine-2,5-dicarboxylic acid pyrazine-2,5-dicarbaldehyde

2,5-Dimethyl pyrazine Suppliers

Global( 621)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Changzhou AniKare Pharmatech Co., Ltd.	+86-0519-8359-8696 +8618018249389	sales@anikare.com	China	9999	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8738	58
Hebei Yanxi Chemical Co., Ltd.	+8618531123677	faithe@yan-xi.com	China	5853	58
Shanghai UCHEM Inc.	+862156762820 +86-13564624040	sales@myuchem.com	China	8834	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-86-13131129325 +8613131129325	sales1@chuanghaibio.com	China	5220	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20121	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	+8613343047651	admin@zlchemi.com	China	3692	58
Shandong Deshang Chemical Co., Ltd.	+86-0531-8875-2665 +8613153039501	info@deshangchem.com	China	661	58
JINING XINHE CHEMICAL CO., LTD	+8615318402391	sales@xinhepharma.com	China	809	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60

Supplier	Advantage
Changzhou AniKare Pharmatech Co., Ltd.	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Hebei Yanxi Chemical Co., Ltd.	58
Shanghai UCHEM Inc.	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Henan Fengda Chemical Co., Ltd	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	58
Shandong Deshang Chemical Co., Ltd.	58
JINING XINHE CHEMICAL CO., LTD	58
Capot Chemical Co.,Ltd.	60

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View Lastest Price from 2,5-Dimethyl pyrazine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-07-17	2,5-Dimethylpyrazine 123-32-0	$36.00-295.00	5g	0.98	25kg	Shanghai UCHEM Inc.
2026-07-17	2,5-Dimethylpyrazine 123-32-0			99.92%	10g	TargetMol Chemicals Inc.
2026-07-09	2,5-Dimethyl pyrazine 123-32-0	$5.00	1KG	98%		Henan Fengda Chemical Co., Ltd

2,5-Dimethylpyrazine
123-32-0
$36.00-295.00
0.98
Shanghai UCHEM Inc.

2,5-Dimethylpyrazine
123-32-0
$0.00
99.92%
TargetMol Chemicals Inc.

2,5-Dimethyl pyrazine
123-32-0
$5.00
98%
Henan Fengda Chemical Co., Ltd

2,5-Dimethyl pyrazine Spectrum

2,5-Dimethyl pyrazine(123-32-0)MS 2,5-Dimethyl pyrazine(123-32-0)¹HNMR 2,5-Dimethyl pyrazine(123-32-0)¹³CNMR 2,5-Dimethyl pyrazine(123-32-0)IR1 2,5-Dimethyl pyrazine(123-32-0)Raman 2,5-Dimethyl pyrazine(123-32-0)ESR

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N,N-Dimethylformamide 2,6-Dimethylpyrazine 3-Ethyl-2,5-diMethylpyrazine

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2,5-Dimethylpyrazine (contains 2,6-isomer) 2,5-DIMETHYL PYRAZINE, NATURAL 2,5-Dimethylpyrazine,99% 5-diMethyl pyrazine 2,5-DiMethylpyrazine, 99% 25GR 2,5-DiMethylpyrazine, 99% 5GR 2,5-Dimethylpyrazine, Research grade 2,5-Dimethyl pyrazine >=99.0% 2,5-DIMETHYLPYRAZINE FOR SYNTHESIS 2,5-DiMethyl pyrazzine Natural 2,5-DiMethyl pyrazine 2,5- twoMethyl pyrazine tomfor 2,5-dimethyl-pyrazin 2,5 AND 2,6-DIMETHYL PYRAZINE 2,5-DIMETHYL-1,4-DIAZINE 2,5-DIMETHYLPYRAZINE AND 2,6-DIMETHYLPYRAZINE 2,5(2,6)-DIMETHYLPYRAZINE MIXTURE 2,5-Dimethyl paradiazine 2 5-DIMETHYLPYRAZINE FCC 2,5-Dimethyl-p-diazine 2,5-Dimethylpiazine dimethylpyrazine,2,5-dimethylpyrazine,2,5-dimethyl-1,4-diazine KETINE GLYCOLINE FEMA NUMBER 3272 FEMA NUMBER 3272 AND 3273 2,5(or6)-Dimethyl pyrazine 2,5-DIMETHYLPYRAZINE (CONTAINS CA. 5% 2,6-ISOMER) 94+% 2,5-DIMETHYL PYRAZINE FEMA NO.3272 2,5-DIMETHYLPYRAZINE (CONTAINS 2,6-ISOMER) 80+% 2,3,5-TRMETHYLPYRAZINE 2,5-Dimethylpyrazine≥ 99% (GC) 2,5-Dimethylpyrazine 98+% Glipizide Impurity 17 2,5-Dimethylpyrazine > 2,5-Dimethylpyrazine, Flavour grade 2,5-Dimethylpyrazine (contains 2,6-isomer)> 2,5-Dimethyl pyrazine USP/EP/BP 2,5-dimethyl pyrazine and 2,6-dimethyl pyrazine mixture 2, 5-Dimethyl Pyrazine CAS 123-32-0 with Best Price 2.5-Dimethyl pryazine 2,5-Dimethylpyrazine, Flavour grade in isooctane 2,5-Dimethylpyrazine, Research grade in isooctane Glipizide Impurity 42 2,5-Dimethylpyrazine, 10 mM in DMSO 2,5-Dimethylprazin 2,5-Dimethyl 2,5-DIMETHYLPYRAZINE FEMA 3272 Pyrazine,2,5-dimethyl- Structural formula 123-32-0 123-23-0 3123-32-0 -NCCH3CHNCCH3CH Heterocyclic Building Blocks Pyrazines

2,5-Dimethyl pyrazine

2,5-Dimethyl pyrazine Properties

SAFETY

Risk and Safety Statements

2,5-Dimethyl pyrazine price More Price(86)

2,5-Dimethyl pyrazine Chemical Properties,Uses,Production

Chemical Properties

Chemical Properties

Occurrence

Uses

Uses

Definition

Application

Preparation

Aroma threshold values

Taste threshold values

General Description

Safety Profile

Purification Methods

2,5-Dimethyl pyrazine synthesis

2,5-Dimethyl pyrazine Preparation Products And Raw materials

Raw materials

Preparation Products

2,5-Dimethyl pyrazine Suppliers

Related articles

View Lastest Price from 2,5-Dimethyl pyrazine manufacturers

2,5-Dimethyl pyrazine Spectrum

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