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Notoginsenoside R1

Notoginsenoside R1 structure

CAS No.: 80418-24-2

Chemical Name:: Notoginsenoside R1

Synonyms: NOTOGINSENOSIDE;Sanchinoside R1;NOTOGINSENOSIDE R1;Notoginsenoside Fb;Sanqi glucoside R1;Notoginseng extracts;Notoginsenoside R1-RM;NOTOGINSENOSIDE R1(SH);Notoginseng saponin R1;Notoginsenoside R1 ,98%

CBNumber:: CB0164186

Molecular Formula:: C47H80O18

Molecular Weight:: 933.14

MDL Number:: MFCD00210535

MOL File:: 80418-24-2.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-08-25 20:17:46

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Notoginsenoside R1 Properties

Melting point	215~217℃
Boiling point	1010.5±65.0 °C(Predicted)
Density	1.39±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	H2O: soluble1mg/mL, clear, colorless
pka	12.85±0.70(Predicted)
form	powder
color	white to off-white
biological source	Panax notoginseng (Burk.) F.H.Chen
Water Solubility	H2O: 1mg/mL, clear, colorless
Henry's Law Constant	6.6×10²⁵ mol/(m³Pa) at 25℃, HSDB (2015)
Major Application	metabolomics vitamins, nutraceuticals, and natural products
InChIKey	LLPWNQMSUYAGQI-OOSPGMBYSA-N
LogP	1.354 (est)
FDA UNII	Z62692362Z
UNSPSC Code	41116107
NACRES	NA.25

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
Hazard Codes	Xn
Risk Statements	22
Safety Statements	24/25
WGK Germany	3
HS Code	29389090
Storage Class	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Oral
Hazardous Substances Data	80418-24-2(Hazardous Substances Data)

Notoginsenoside R1 price More Price(59)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	N3915	Notoginsenoside R1 ≥98% (HPLC)	80418-24-2	10mg	$383	2026-04-30	Buy
Sigma-Aldrich	N3915	Notoginsenoside R1 ≥98% (HPLC)	80418-24-2	50mg	$1020	2023-06-20	Buy
TCI Chemical	N1129	Notoginsenoside R1 >98.0%(HPLC)	80418-24-2	50mg	$127	2026-04-30	Buy
TCI Chemical	N1129	Notoginsenoside R1 >98.0%(HPLC)	80418-24-2	10mg	$95	2022-04-27	Buy
Cayman Chemical	29691	Notoginsenoside R1 ≥98%	80418-24-2	5mg	$80	2026-04-30	Buy

Product number	Packaging	Price	Buy
N3915	10mg	$383	Buy
N3915	50mg	$1020	Buy
N1129	50mg	$127	Buy
N1129	10mg	$95	Buy
29691	5mg	$80	Buy

Notoginsenoside R1 Chemical Properties,Uses,Production

Description

Notoginsenoside R1 is a ginsenoside found in Panax notoginseng that is dammarane which is substituted by hydroxy groups at the 3beta, 6alpha, 12beta and 20 pro-S positions, in which the hydroxy groups at positions 6 and 20 have been converted to the corresponding beta-D-xylopyranosyl-(1->2)-beta-D-glucopyranoside and beta-D-glucopyranoside respectively, and in which a double bond has been introduced at the 24-25 position. It is a beta-D-glucoside, a 12beta-hydroxy steroid, a 3beta-hydroxy steroid, a disaccharide derivative, a ginsenoside, a tetracyclic triterpenoid and a 3beta-hydroxy-4,4-dimethylsteroid. It derives from a hydride of a dammarane.

Uses

Notoginsenoside R1 is an active ingredient isolated from Panax notoginseng that induces tissue-type plasminogen activator synthesis in cultured human umbilical vein endothelial cells.

Application

Notoginsenoside R1 has a role as a plant metabolite, an antioxidant, a neuroprotective agent, an apoptosis inducer and a phytoestrogen.

Chemical Properties

Derived from the dried root of Panax ginseng of the Araliaceae family

Uses

Notoginsenoside R1 acts as an anti-inflammatory agent, inhibiting TNF-α induced PAI-1 production in aortic smooth muscle cells in humans.

Definition

ChEBI: Notoginsenoside R1 is a ginsenoside found in Panax notoginseng that is dammarane which is substituted by hydroxy groups at the 3beta, 6alpha, 12beta and 20 pro-S positions, in which the hydroxy groups at positions 6 and 20 have been converted to the corresponding beta-D-xylopyranosyl-(1->2)-beta-D-glucopyranoside and beta-D-glucopyranoside respectively, and in which a double bond has been introduced at the 24-25 position. It has a role as a plant metabolite, an antioxidant, a neuroprotective agent, an apoptosis inducer and a phytoestrogen. It is a beta-D-glucoside, a 12beta-hydroxy steroid, a 3beta-hydroxy steroid, a disaccharide derivative, a ginsenoside, a tetracyclic triterpenoid and a 3beta-hydroxy-4,4-dimethylsteroid. It derives from a hydride of a dammarane.

Biological Activity

Notoginsenoside R1 has been shown to exhibit antooxidant, anti-inflammatory, antiapoptotic, and immune-stimulatory properties.

in vivo

Notoginsenoside R1 (5 mg/kg/h; infused via the right jugular vein) increases red blood cell velocity, reduces the number of adherent leukocytes and inhibits mast cell degranulation and cytokine elevation in rats^[3].

Animal Model:	Male Sprague-Dawley (SD) rats (200-250 g)^[3]
Dosage:	5 mg/kg/h
Administration:	Infused 20 min before LPS infusion via the right jugular vein
Result:	Ameliorated the LPS-induced reduction in the mesenteric venular shear rate to some extent. Attenuated the LPS-induced adhesion of leukocytes to the venular wall. Inhibited mast cell degranulation and cytokine elevation.

Notoginsenoside R1 Preparation Products And Raw materials

Raw materials

Preparation Products

Notoginsenoside R1 Suppliers

Global( 376)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ShangHai YuanYe Biotechnology Co., Ltd.	15026964105	shyysw007@163.com	China	4998	60
Xi'an Kono chem co., Ltd.	029-84385017-8006 15891391030	info@konochemical.com	China	642	58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd	13186333400 19299362551	cuichengbio@163.com	China	1924	58
Beijing I-puritech Science & Technology Co.,Ltd	13311015623	zhangping@i-puritech.com	China	116	58
Shanghai Moqi Biological Technology Co., LTD	13341702378	190129269@qq.com	China	9998	58
Nanjing bingcheng Biotechnology Co., Ltd.	18805194892	2727751293@qq.com	China	172	58
Chembest Research Laboratories Limited	021-20908456	sales@BioChemBest.com	China	5996	61
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Adamas Reagent, Ltd.	400-6009262 15618770481	yhx@titansci.com	China	14098	59
China DongFan Chemical Co.,LTD	86-0571-85151182		China	5681	66

Supplier	Advantage
ShangHai YuanYe Biotechnology Co., Ltd.	60
Xi'an Kono chem co., Ltd.	58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd	58
Beijing I-puritech Science & Technology Co.,Ltd	58
Shanghai Moqi Biological Technology Co., LTD	58
Nanjing bingcheng Biotechnology Co., Ltd.	58
Chembest Research Laboratories Limited	61
TCI (Shanghai) Development Co., Ltd.	81
Adamas Reagent, Ltd.	59
China DongFan Chemical Co.,LTD	66

View Lastest Price from Notoginsenoside R1 manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-11	Panax notoginseng extract 80418-24-2		1KG	≥98% HPLC	1000KG	Changsha Staherb Natural Ingredients Co., Ltd.
2026-09-11	Notoginsenoside R1 80418-24-2		1KG	80% HPLC	1000KG	Changsha Staherb Natural Ingredients Co., Ltd.
2026-07-27	Notoginsenoside R1 80418-24-2	$37.00-98.00		99.82%	10g	TargetMol Chemicals Inc.

Panax notoginseng extract
80418-24-2
$0.00
≥98% HPLC
Changsha Staherb Natural Ingredients Co., Ltd.

Notoginsenoside R1
80418-24-2
$0.00
80% HPLC
Changsha Staherb Natural Ingredients Co., Ltd.

Notoginsenoside R1
80418-24-2
$37.00-98.00
99.82%
TargetMol Chemicals Inc.

Notoginsenoside R1 Spectrum

Notoginsenoside R1(80418-24-2)MS Notoginsenoside R1(80418-24-2)¹HNMR

80418-24-2(Notoginsenoside R1)Related Search:

PANAX NOTOGINSENOSIDES Saponin Ginseng extract Dioscin Escin

TRIBULOSIDE Notoginsenoside R2 Notoginseng triterpenes Notoginsenoside Ft1 20(R)-Notoginsenoside R2

Notoginsenoside FP2 NotoginsenosideFc GYPENOSIDE IX Notoginsenoside Fa Notoginsenoside S

3,3,5,5-Tetramethylcyclohexanol GINSENOSIDEF1 Ginsenoside Rg1

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(3β,6α,12β)-20-(β-D-Glucopyranosyloxy)-3,12-dihydroxydammar-24-en-6-yl 2-O-β-D-xylopyranosyl-β-D-glucopyranoside Notoginsenoside Fb NOTOGINSENOSIDE R1 NOTOGINSENOSIDE R1(SH) glucopyranosyloxy)-3,12-dihydroxydammar-24-en-6-yl2-O-β-D-xylopyranosyl- Sanchinoside R1 Notoginsenoside R1，Sanchinoside R1 Notoginsenoside R1 ,98% Notoginsenoside R1, 98%, from Panax notoginseng (Burk.)F.H.Chen Sanqi glucoside R1 2-[2-[6-[[4,5-dihydroxy-6-(hydroxymethyl)-3-methyl-2-oxanyl]oxy]-3,12-dihydroxy-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-methylhept-5-en-2 Notoginseng extracts Notoginsenoside R1 Standard β-D-Glucopyranoside, (3β,6α,12β)-20-(β-D-glucopyranosyloxy)-3,12-dihydroxydammar-24-en-6-yl 2-O-β-D-xylopyranosyl- (3beta,6alpha,12beta)-20-(beta-D-Glucopyranosyloxy)-3,12-dihydroxydammar-24-en-6-yl 2-O-beta-D-Xylopyranosyl-beta-D-glucopyranoside (2S,3R,4S,5S,6R)-2-[(2S)-2-[(3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-6-[(2R,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxyoxan-2-yl]oxy-3,12-dihydroxy-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-methylhept-5-en-2-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol TIANFU-CHEM Notoginsenoside R1 Panax notoginseng saponin R1 (2S,3R,4S,5S,6R)-2-(((S)-2-((3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-6-(((2R,3R,4S,5S,6R)-4,5-Dihydroxy-6-(hydroxymethyl)-3-(((2S,3R,4S,5R)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-3,12-dihydroxy-4,4,8,10,14-pentamethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-6-methylhept-5-en-2-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol Notoginseng saponin R1 Notoginseng saponin FP2 Panax Notoginseng Saponins, PNS Notoginsenoside R1-RM Notoginsenoside R1 Impurity Notoginsenoside R1, 10 mM in DMSO NOTOGINSENOSIDE Panax notoginsenoside R1 80418-24-2 C47H80O18 chemical reagent Inhibitors pharmaceutical intermediate phytochemical reference standards from Chinese medicinal herbs (TCM). standardized herbal extract